Manufacturer: Sigmund Promedica
Salt Composition : Phenobarbitone(30mg), Phenytoin(100mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Cobarb 30mg/100mg Tablet is taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration advised by your doctor as its long-term use may be habit-forming. Do not skip any doses, but if you miss a dose of this medicine, take it as soon as you remember. Finish the full course of treatment even if you feel better. Stopping the medication without talking to the doctor may cause rebound seizures.
Phenobarbital increases the amount of time chloride channels are open, consequently depressing the central nervous system. This action occurs by acting on GABA-A receptor subunits
Phenytoin is a hydantoin derivative, a first-generation anti-convulsant drug that is effective in the treatment of generalized tonic-clonic seizures, complex partial seizures, and status epilepticus without significantly impairing neurological function
After administration of phenobarbitai tablets, the maximum phenobarbitai serum concentration was 5.5 mg/liter at 2.3 hours after the dose. Adjusted absolute availability of phenobarbital from the tablets studied was 94.9 per cent (range 81-111.9 per cent). The elimination half-life averaged 5.1 days for the oral dose
Phenytoin follows nonlinear (or zero-order) kinetics at therapeutic concentrations, because the rate of metabolism is close to the maximum capacity of the enzymes involved. In nonlinear kinetics, clearance and half-life fluctuate with plasma concentration
Nausea
Vomiting
Vertigo
Nystagmus (involuntary eye movement)
Double vision
Sleepiness
Anemia (low number of red blood cells)
Peripheral neuropathy (tingling and numbness of feet and hand)
Gingival hypertrophy (gum enlargement)
Softening of bones
Abnormal hair growth
Phenobarbital is contraindicated in patients with known barbiturate sensitivity. Barbiturates, including phenobarbital, are contraindicated in a patient with a history/manifest or latent porphyria, liver impairment, and large doses in patients with nephritic syndrome
diabetes.
osteomalacia, or softening of bones.
low amount of albumin proteins in the blood.
porphyria.
a type of blood disorder with a decrease in all types of blood cells called pancytopenia.
decreased blood platelets.
very low levels of granulocytes, a type of white blood cell.
Cobarb 30mg/100mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is unsafe to consume alcohol with Cobarb 30mg/100mg Tablet.
Cobarb 30mg/100mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Baby should be monitored for excessive sleepiness and weight gain
Epilepsy.
Status epilepticus.
Hyperbilirubinemia of new born (off-label)
Pruritus.
Cerebral irritation - acute cerebral event.
Intractable seizures in terminal period.
Sedative.
Hypnotic.
Phenytoin is indicated to treat grand mal seizures, complex partial seizures, and to prevent and treat seizures during or following neurosurgery
Do not chew, crush or break it. Cobarb 30mg/100mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
If you miss a dose of Cobarb 30mg/100mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines
You have been prescribed Cobarb 30mg/100mg Tablet to treat and prevent epilepsy (seizures).
Always make sure that that you have a sufficient amount of medicine present with you.
It may increase blood sugar levels. Monitor your sugar level regularly and inform your doctor if you see a spike in your levels.
Cobarb 30mg/100mg Tablet may cause swollen gum (gum hypertrophy), hence take care of oral or dental hygiene.
Lifestyle changes like regular light exercise and a stress free life along with a healthy diet can help the medicine work better.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Cobarb 30mg/100mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
