Manufacturer: Cipla Ltd
Salt Composition : Phenylpropanolamine(12.5mg), Bromhexine(4mg), Dextromethorphan Hydrobromide(5mg)
Bottle of 60ml Expectorant
(Inclusive of all taxes)
Cofdex P Expectorant is taken with or without food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your healthcare team know about all other medications you are taking as some may affect, or be affected by this medicine.
Cofdex P Expectorant is a combination of three medicines: Phenylpropanolamine, Bromhexine and Dextromethorphan Hydrobromide. Phenylpropanolamine is a decongestant which narrows the small blood vessels providing relief from congestion or stuffiness in the nose. Bromhexine is a mucolytic which thins and loosens mucus (phlegm), making it easier to cough out. Dextromethorphan Hydrobromide is a cough suppressant that relieves cough by reducing the activity of cough centre in the brain.
The drug was shown to be rapidly absorbed with a mean tmaxof 1.47 ± 0.49 h and a mean elimination half-life of 4.0 ± 0.5 h. Phenylpropanolamine is predominantly excreted via the kidney with a mean renal clearance of 0.646 ± 0.089 liter/kg/h and 90.2 ± 1.7% excreted unchanged in the urine.Bromhexine hydrochloride is rapidly absorbed from the gastrointestinal tract and undergoes extensive first-pass metabolism in the liver. Its oral bioavailability is stated to be only about 20%. It is widely distributed to body tissues and is highly bound to plasma proteins.Following oral administration, dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood–brain barrier.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Cofdex P
Nausea
Diarrhea
Bloating
Indigestion
Headache
Dizziness
Sweating
High blood pressure
Insomnia (difficulty in sleeping)
Palpitations
Skin rash
Upset stomach
Hypersensitivity to Cofdex P Expectorant is a contraindication. In addition, Cofdex P Expectorant should not be used if you have the following conditions:
Concomitant use with a monoamine oxidase inhibitor
Glaucoma
Hypersensitivity
Hypertension
Hyperthyroidism
Intestinal obstruction
Prostatic hypertrophy
Use within 2 weeks of discontinuing a monoamine oxidase inhibitor
Cofdex P Expectorant may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Caution is advised when consuming alcohol with Cofdex P Expectorant. Please consult your doctor.
Information regarding the use of Cofdex P Expectorant during breastfeeding is not available. Please consult your doctor.
Use with caution
Below 9years: Contraindicated
BROMHEXINE+DEXTROMETHORPHAN+PHENYLPROPANOLAMINE is used in the treatment of dry cough which is associated with cold/flu, allergies, or throat irritants. It can suppress severe cough and helps to relieve congestion. It can also provide relief from a sore throat which is often accompanied by a dry cough.
If you use other drugs or over the counter products at the same time, the effects of Cofdex P Expectorant may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Cofdex P Expectorant may interact with the following drugs and products:
Acebutolol
Alcohol
Amiodarone
Atropine
Bromocriptine
Cough and cold medicines
Debrisoquine
Doxepin
Ephedrine
Furazolidone
Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Cofdex P Expectorant may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
If you miss a dose of Cofdex P Expectorant, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Cofdex P Expectorant is prescribed to get relief from a dry cough.
Take exactly as directed by your doctor or on the label. Do not increase the dosage or take for longer than is recommended.
Consult your doctor if you do not see any improvement and have a cough for more than 7 days.
Let your doctor know if you are taking any anti-depressants.
Inform your doctor if you have had a cough for a long time or if you have asthma or suffer from serious asthma attacks, or if your cough is accompanied by a fever, rash, or persistent headache.
Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Cofdex P Expectorant may be taken with or without food, but it is better to take it at a fixed time.
