Manufacturer: Stadmed Pvt Ltd
Salt Composition : Caffeine(15mg), Chlorpheniramine Maleate(2mg), Paracetamol(500mg), Phenylephrine(5mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Cold Off Tablet is used to treat common cold symptoms. It provides temporary relief from stuffiness in the nose. It also helps to relieve allergy symptoms like runny nose and watery eyes.
This medication may be taken with or without food preferably one hour before you travel. Take it in a dose and duration as advised by the doctor. But, before taking it, inform doctor if you are suffering from depression and taking its medicines.
Dizziness may occur as its side effect, so do not drive or do anything that requires mental focus. You should avoid drinking alcohol while taking this medicine, as it may cause excessive sleepiness.
Caffeine action is thought to be mediated via several mechanisms: the antagonism of adenosine receptors, the inhibition of phosphodiesterase, the release of calcium from intracellular stores, and antagonism of benzodiazepine receptors
Chlorpheniramine helps control the symptoms of cold or allergies but will not treat the cause of the symptoms or speed recovery. Chlorpheniramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms.
Paracetamol has a central analgesic effect that is mediated through activation of descending serotonergic pathways. Debate exists about its primary site of action, which may be inhibition of prostaglandin (PG) synthesis or through an active metabolite influencing cannabinoid receptors
Phenylephrine is an agonist of α1-adrenoceptors. Nasal decongestant action is mediated by activation of α1-adrenoceptors in the arterioles of the nasal mucosa. This causes vasoconstriction, which leads to decreased edema and increased drainage of the sinus cavities
Caffeine is rapidly and completely absorbed within an hour following ingestion. It is distributed throughout body water and readily crosses cell membranes including the brain. Its primary mechanisms for stimulatory activity appear to be the blocking of adenosine receptors and inhibition of phosphodiesterases
Chlorpheniramine has a serum half-life of approximately 20 hours in adults, and elimination from the body is primarily by metabolism to monodesmethyl and didesmethyl compounds. The half-life is increased in the presence of renal dysfunction and decreased in children.
It distributes rapidly and evenly throughout most tissues and fluids and has a volume of distribution of approximately 0.9L/kg. 10 to 20% of the drug is bound to red blood cells. Paracetamol is extensively metabolised (predominantly in the liver), the major metabolites being the sulphate and glucuronide conjugates.
Phenylephrine is readily and completely absorbed from the gastro-intestinal tract after oral administration. It is subject to extensive presystemic metabolism in the gut wall and therefore has a systemic bioavailability of approximately 40% relative to intravenous dosing.
Nausea
Vomiting
Headache
High blood pressure
Arrhythmia (irregular heartbeats)
Blurred vision
Breathlessness
Itching
Restlessness
Reflex bradycardia
Excitation
Epigastric pain
Neck pain
Tremors
Hypertensive crisis
Eye pain
Stinging in the eyes
Photophobia
Conjunctival sensitivity
Preterm and low birth weight infants
Fainting
Myocardial infarction
Subarachnoid hemorrhage
Although there are no absolute contraindications to caffeine, there are some medical conditions in which caution is necessary, which includes: Severe anxiety. Cardiovascular disease or symptomatic cardiac arrhythmias. Peptic ulcer disease or gastroesophageal reflux disease
overactive thyroid gland.
closed angle glaucoma.
high blood pressure.
stenosing peptic ulcer.
blockage of the stomach or intestine.
blockage of the urinary bladder.
enlarged prostate.
an inability to completely empty the bladder.
caloric undernutrition.
acute liver failure.
liver problems.
a condition where the body is unable to maintain adequate blood flow called shock.
acetaminophen overdose.
acute inflammation of the liver due to hepatitis C virus.
overactive thyroid gland.
acidosis, a high level of acid in the blood.
high blood pressure.
significant uncontrolled high blood pressure.
a heart attack.
coronary artery disease.
partial heart block.
rapid ventricular heartbeat.
Cold Off Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is unsafe to consume alcohol with Cold Off Tablet.
Cold Off Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
People most commonly use caffeine for mental alertness, headache, migraine, athletic performance, memory, and obesity. It is also used for asthma, gallbladder disease, ADHD, low blood pressure, depression, and many other conditions, but there is no good scientific evidence to support most of these other uses
Chlorpheniramine relieves red, itchy, watery eyes; sneezing; itchy nose or throat; and runny nose caused by allergies, hay fever, and the common cold. Chlorpheniramine helps control the symptoms of cold or allergies but will not treat the cause of the symptoms or speed recovery
Paracetamol is a mild analgesic and antipyretic, and is recommended for the treatment of most painful and febrile conditions, for example, headache including migraine, toothache, neuralgia, colds and influenza, sore throat, backache, rheumatic pain and dysmenorrhoea.
The FDA-approved indication for intravenous (IV) phenylephrine hydrochloride is for increasing blood pressure in adults with clinically significant hypotension resulting primarily from vasodilation in such settings as septic shock or anesthesia
By speeding up the nervous system, stimulant medications can increase blood pressure and speed up the heartbeat. Caffeine can also speed up the nervous system. Taking caffeine along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure.
eluxadoline.
idelalisib.
isocarboxazid.
ivacaftor.
sodium oxybate.
tranylcypromine.
Arguably, the most important pharmacodynamic drug interaction with paracetamol is that of N-acetylcysteine in attenuating the hepatotoxicity that results from supratherapeutic intake and overdose of paracetamol. The role of N-acetylcysteine in managing paracetamol overdose is well established
iobenguane I
isocarboxazid.
linezolid.
phenelzine.
procarbazine.
selegiline transdermal.
tranylcypromine.
This medicine is usually recommended only for a short time until your symptoms are cleared. Do not take it for longer than 7 days in a row.
STORE BELOW 30 DEGREES C.
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Seek emergency medical treatment or contact the doctor in case of an overdose.
You can take this drug in the form of a tablet, capsule, or liquid form by mouth with or without food. This medicine is usually recommended only for a short time until your symptoms are cleared. Do not take it for longer than 7 days in a row.
Ques: What is Cold Off Tablet?
Ans: This drug performs its action by obstructing the release H1 receptor (chemical messengers) in the body. It is used to avoid hay fever, allergic reactions and urticaria, nasal congestion and common cold symptoms.
Ques: What are the uses of Cold Off Tablet?
Ans: It is used for the treatment and prevention of conditions and symptoms of diseases like Hay fever, allergic reactions, and urticaria.
Ques: What are the Side Effects of Cold Off Tablet?
Ans: These side effects include dry mouth, aplastic anemia, jaundice, and blurred vision. Apart from these, using It may further lead to drowsiness, sleepiness, and double vision.
Ques: What are the instructions for storage and disposal Cold Off Tablet?
Ans: It should be stored at room temperature, away from heat and direct light. Keep it away from the reach of children and pets. A doctor should be consulted regarding the dosage of Chlorpheniramine. The patient should consult a doctor for its further uses and side effects and should inform the doctor about any ongoing medications and treatment before using to avoid undesirable effects.
Ques: Should I use Cold Off Tablet empty stomach, before food or after food?
Ans: The consumption of this medication is done orally. If you take this medication with the food, the reactions that took place in the body carry outs in a much effective manner. Your stomach might get upset if you take this medication on an empty stomach.
Ques: How long do I need to use Cold Off Tablet before I see improvement of my conditions?
Ans: In most of the cases, the average time taken by this medication to reach its peak effect is around 1 day to 3 months, before noticing an improvement in the condition. But the same duration is not mandatory for everyone and so, it is not a standard time period for this medication's action.
Ques: Is there any food or drink I need to avoid?
Ans: There is no specific food product to avoid, under usage of this medication. It will be beneficial to keep your diet healthy and to ignore street food in order to avoid any kind of harmful bacterial intake. It is also advised to stay away from drinking and smoking to uplift your health.
Ques: Will Cold Off Tablet be more effective if taken in more than the recommended dose?
Ans: There is no need to take this medication more than its recommended doses. Taking over-dosage of this medication may trigger side effects. If the severity of the condition is not reducing with the recommended dosage of this drug, then the doctor should be consulted for re-examining your condition.
