Manufacturer: Sresan Pharmaceuticals
Salt Composition : Chlorpheniramine Maleate(1mg/5ml), Paracetamol(125mg/5ml), Phenylephrine(5mg/5ml)
Bottle of 60ml Syrup
(Inclusive of all taxes)
This medication may be taken with or without food preferably one hour before you travel. Take it in a dose and duration as advised by the doctor. But, before taking it, inform doctor if you are suffering from depression and taking its medicines.
Chlorpheniramine helps control the symptoms of cold or allergies but will not treat the cause of the symptoms or speed recovery. Chlorpheniramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms.
Phenylephrine is an agonist of α1-adrenoceptors. Nasal decongestant action is mediated by activation of α1-adrenoceptors in the arterioles of the nasal mucosa. This causes vasoconstriction, which leads to decreased edema and increased drainage of the sinus cavities.
Paracetamol has a central analgesic effect that is mediated through activation of descending serotonergic pathways. Debate exists about its primary site of action, which may be inhibition of prostaglandin (PG) synthesis or through an active metabolite influencing cannabinoid receptors
Phenylephrine is readily and completely absorbed from the gastro-intestinal tract after oral administration . It is subject to extensive presystemic metabolism in the gut wall and therefore has a systemic bioavailability of approximately 40% relative to intravenous dosing
Chlorpheniramine has a serum half-life of approximately 20 hours in adults, and elimination from the body is primarily by metabolism to monodesmethyl and didesmethyl compounds. The half-life is increased in the presence of renal dysfunction and decreased in children
It distributes rapidly and evenly throughout most tissues and fluids and has a volume of distribution of approximately 0.9L/kg. 10 to 20% of the drug is bound to red blood cells. Paracetamol is extensively metabolised (predominantly in the liver), the major metabolites being the sulphate and glucuronide conjugates.
Dryness in mouth
Sleepiness
Drowsiness
Loss of appetite
Nausea
MAO inhibitor use w/in 14 days, Urinary retention, CAD, Uncontrolled or severe HTN. Caution if HTN, arrhythmias, cardiovascular disease, diabetes mellitus, angle-closure glaucoma, hyperthyroidism, renal impairment, PKU (phenylalanine-containing forms),
overactive thyroid gland.
closed angle glaucoma.
high blood pressure.
stenosing peptic ulcer.
blockage of the stomach or intestine.
blockage of the urinary bladder.
enlarged prostate.
an inability to completely empty the bladder
caloric undernutrition.
acute liver failure.
liver problems.
a condition where the body is unable to maintain adequate blood flow called shock.
acetaminophen overdose.
acute inflammation of the liver due to hepatitis C virus.
7 YEARS
This medication is an antihistamine, prescribed for allergic conditions such as itchy and watery eyes, sneezing, runny nose, hay fever and common cold. It may also be used to relieve the itching from insect bites and bee stings.
The FDA-approved indication for intravenous (IV) phenylephrine hydrochloride is for increasing blood pressure in adults with clinically significant hypotension resulting primarily from vasodilation in such settings as septic shock or anesthesia.
Paracetamol is a mild analgesic and antipyretic, and is recommended for the treatment of most painful and febrile conditions, for example, headache including migraine, toothache, neuralgia, colds and influenza, sore throat, backache, rheumatic pain and dysmenorrhoea
iobenguane
isocarboxazid.
linezolid.
phenelzine.
procarbazine.
selegiline transdermal.
tranylcypromine.
eluxadoline.
idelalisib.
isocarboxazid.
ivacaftor.
sodium oxybate.
tranylcypromine.
Arguably, the most important pharmacodynamic drug interaction with paracetamol is that of N-acetylcysteine in attenuating the hepatotoxicity that results from supratherapeutic intake and overdose of paracetamol. The role of N-acetylcysteine in managing paracetamol overdose is well established.
Shake well before use. Coldrif Syrup may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
Do not panic. Unless your child’s doctor has advised a specific regime for your child, you can give the missed dose as soon as you remember it. Skip the missed dose if it’s almost the time for the next dose. Follow the prescribed dosing schedule and do not give a double dose to catch up with the missed dose.
Consult a doctor before taking any medicines
Chlorpheniramine Maleate
Avoid driving or operating dangerous machinery as it may decrease alertness.
Avoid consuming alcohol when taking the Chlorpheniramine Maleate, as it may cause excessive sleepiness or drowsiness.
Paracetamol
Paracetamol should be taken with food or milk to prevent upset stomach.
Take it as per the dose and duration prescribed by your doctor. Long term use may lead to serious complications such as stomach bleeding and kidney problems.
Do not take indigestion remedies (antacids) within 2 hours of taking Paracetamol.
Avoid consuming alcohol while taking this medicine as it can increase your risk of stomach problems.
Inform your doctor if you have liver disease as your dose may need to be adjusted.
Your doctor may regularly monitor your kidney function, liver function and levels of blood components if you are taking this medicine for long-term treatment.
Phenylephrine
Oral phenylephrine should be taken with food
Phenylephrine can make you restless, so don't take it too close to bedtime
Do not use this medicine without doctor's advice if you are pregnant or breast feeding
Smoking may worsen the effect; therefore use of tobacco should be avoided.
Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Coldrif Syrup may be taken with or without food, but it is better to take it at a fixed time.
Q. Does chlorpheniramine or chlorpheniramine maleate cause increase in blood pressure/ drowsy/non drowsy/sedating/get you high/keep you awake/sleepiness/make you tired/weight gain?
Chlorpheniramine causing these side effects is common or rare. Always consult your doctor, if you experience any of these side effects
Q. Is chlorpheniramine like Benadryl?
No, chlorpheniramine is different from Benadryl
Q. Is chlorpheniramine prescription?
Yes, it is available with doctor’s prescription only
Q. Can I take chlorpheniramine or chlorpheniramine maleate with Panadol/ cetirizine /Zyrtec/ Allegra/ warfarin/ diphenhydramine/ ibuprofen/Claritin/guaifenesin/Benadryl?
Yes, but taking other medicines may alter the effects of chlorpheniramine. Always consult your doctor for the change of dose regimen or an alternative drug of choice that may strictly be required
Q. What if I vomit after taking Paracetamol?
If you vomit in less than 30 minutes after having a dose of Paracetamol tablets or syrup, retake the same dose again. If you vomit after 30 minutes of a dose, you do not need to take another one until the next standard dose.
Q. When will I feel better after taking the Paracetamol?
Usually, you will start feeling better after about half an hour of taking a Paracetamol.
Q. How often can I take the Paracetamol?
You should only take four doses of Paracetamol in 24 hours. There should be a gap of at least 4 hours between two doses. Do not take Paracetamol for more than 3 days without consulting a doctor first.
Q. Does Paracetamol make babies sleepy?
No, Paracetamol does not make babies sleepy. It is a pain-relieving medicine that is also used to control high fever.
