Manufacturer: Medopharm
Salt Composition : Caffeine(30mg), Chlorpheniramine Maleate(2mg), Paracetamol(500mg), Phenylephrine(10mg)
Strip of 10 Tablet
(Inclusive of all taxes)
The common cold is a respiratory illness affecting the nose and throat, mostly caused by viruses known as 'rhinovirus.' The virus attacks the body through the mouth, nose, or eyes and spreads quickly through droplets in the air when a person who is sick sneezes, coughs, or talks.
COLGIN PLUS 30MG TABLET is composed of four medicines, namely: Chlorpheniramine (anti-histamine), Phenylephrine (decongestant), Paracetamol (mild analgesic and antipyretic), and Caffeine (a stimulant). Chlorpheniramine belongs to the class of antihistamines (anti-allergic drugs) that works by blocking the action of histamine, a substance responsible for causing allergic reactions. Phenylephrine helps in shrinking the blood vessels in the nasal passage, thereby reducing the stuffy nose. Paracetamol is an analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting the production of certain chemical messengers in the brain known as 'prostaglandins' responsible for pain and fever. Caffeine acts as a common stimulant, which decreases sleepiness caused by Chlorpheniramine and speeds up the action of all the medicines present in COLGIN PLUS 30MG TABLET.
Caffeine action is thought to be mediated via several mechanisms: the antagonism of adenosine receptors, the inhibition of phosphodiesterase, the release of calcium from intracellular stores, and antagonism of benzodiazepine receptors
Chlorpheniramine helps control the symptoms of cold or allergies but will not treat the cause of the symptoms or speed recovery. Chlorpheniramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms.
Paracetamol has a central analgesic effect that is mediated through activation of descending serotonergic pathways. Debate exists about its primary site of action, which may be inhibition of prostaglandin (PG) synthesis or through an active metabolite influencing cannabinoid receptors
Phenylephrine is an agonist of α1-adrenoceptors. Nasal decongestant action is mediated by activation of α1-adrenoceptors in the arterioles of the nasal mucosa. This causes vasoconstriction, which leads to decreased edema and increased drainage of the sinus cavities
Drowsiness
Nervousness
Headache
Dizziness
Insomnia (difficulty falling or staying asleep)
Allergic reactions
Although there are no absolute contraindications to caffeine, there are some medical conditions in which caution is necessary, which includes: Severe anxiety. Cardiovascular disease or symptomatic cardiac arrhythmias. Peptic ulcer disease or gastroesophageal reflux disease
overactive thyroid gland.
closed angle glaucoma.
high blood pressure.
stenosing peptic ulcer.
blockage of the stomach or intestine.
blockage of the urinary bladder.
enlarged prostate.
an inability to completely empty the bladder.
caloric undernutrition.
acute liver failure.
liver problems.
a condition where the body is unable to maintain adequate blood flow called shock.
acetaminophen overdose.
acute inflammation of the liver due to hepatitis C virus.
overactive thyroid gland.
acidosis, a high level of acid in the blood.
high blood pressure.
significant uncontrolled high blood pressure.
a heart attack.
coronary artery disease.
partial heart block.
rapid ventricular heartbeat.
The safety of COLGIN PLUS 30MG TABLET in pregnant women is unknown. Therefore, it is given to pregnant women only if the doctor thinks the benefits outweigh the risks.
You are recommended not to consume alcohol along with COLGIN PLUS 30MG TABLET to avoid excessive drowsiness and sleepiness.
COLGIN PLUS 30MG TABLET is known to pass through milk in small amounts. Use in breastfeeding women is not recommended as it may cause unpleasant side effects to the baby like unusual irritability, excitement.
People most commonly use caffeine for mental alertness, headache, migraine, athletic performance, memory, and obesity. It is also used for asthma, gallbladder disease, ADHD, low blood pressure, depression, and many other conditions, but there is no good scientific evidence to support most of these other uses
Chlorpheniramine relieves red, itchy, watery eyes; sneezing; itchy nose or throat; and runny nose caused by allergies, hay fever, and the common cold. Chlorpheniramine helps control the symptoms of cold or allergies but will not treat the cause of the symptoms or speed recovery
Paracetamol is a mild analgesic and antipyretic, and is recommended for the treatment of most painful and febrile conditions, for example, headache including migraine, toothache, neuralgia, colds and influenza, sore throat, backache, rheumatic pain and dysmenorrhoea.
The FDA-approved indication for intravenous (IV) phenylephrine hydrochloride is for increasing blood pressure in adults with clinically significant hypotension resulting primarily from vasodilation in such settings as septic shock or anesthesia
By speeding up the nervous system, stimulant medications can increase blood pressure and speed up the heartbeat. Caffeine can also speed up the nervous system. Taking caffeine along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure.
eluxadoline.
idelalisib.
isocarboxazid.
ivacaftor.
sodium oxybate.
tranylcypromine.
Arguably, the most important pharmacodynamic drug interaction with paracetamol is that of N-acetylcysteine in attenuating the hepatotoxicity that results from supratherapeutic intake and overdose of paracetamol. The role of N-acetylcysteine in managing paracetamol overdose is well established
iobenguane I
isocarboxazid.
linezolid.
phenelzine.
procarbazine.
selegiline transdermal.
tranylcypromine.
Swallow it as a whole with a glass of water. Do not crush, break or chew it.
Store in a cool and dry place away from sunlight
Avoid alcohol consumption with COLGIN PLUS 30MG TABLET as it may cause tiredness, drowsiness, or lack of concentration.
Do not take COLGIN PLUS 30MG TABLET if you have taken an MAO inhibitor (anti-depressant medication) in the past 14 days.
Please inform your doctor if you are pregnant or breastfeeding before starting COLGIN PLUS 30MG TABLET as it contains caffeine, which can pass in the breast milk, which may have a stimulating effect on a breastfed child.
Take COLGIN PLUS 30MG TABLET with food or as advised by your doctor. Swallow it as a whole with a glass of water. Do not crush, break or chew it.
