Colicraft 1Million IU (Injection)


Colicraft 1Million IU Injection is given under the supervision of a healthcare professional. You should not self-administer this medicine at home. The dose and duration will be decided by your doctor based on the severity and type of infection you have. Get the injection regularly for as long as your doctor has prescribed to get maximum benefits.



Basic Information

Mechanism Of Action

Colistimethate is a surface active agent which penetrates into and disrupts the bacterial cell membrane. Colistimethate is polycationic and has both hydrophobic and lipophilic moieties. It interacts with the bacterial cytoplasmic membrane, changing its permeability. This effect is bactericidal.

Pharmacokinets

CMS is mainly excreted unchanged in urine (70% on average), with a typical renal clearance estimated at 103 ml/min-close to the glomerular filtration rate. Colistin elimination is essentially extrarenal, given that its renal clearance is 1.9 ml/min, consistent with extensive reabsorption

Side Effects

Upset stomach

Rash

Paresthesia (tingling or pricking sensation)

Dizziness

Slurred speech

Vertigo

Fever

Contra Indications

diarrhea from an infection with Clostridium difficile bacteria.

myasthenia gravis, a skeletal muscle disorder.

a type of muscle paralysis due to blocked nerve function called neuromuscular blockade.

decreased kidney function.


Pregnancy Related Information

Colicraft 1Million IU Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.


Product And Alcohol Interaction

Consuming alcohol with Colicraft 1Million IU Injection does not cause any harmful side effects.


Breast Feeding Related Information

Colicraft 1Million IU Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.


Indications

Colistimethate Sodium is indicated in adults and children including neonates for the treatment of serious infections due to selected aerobic Gram-negative pathogens in patients with limited treatment options 

Interactions

amphotericin B deoxycholate.

atracurium.

bacitracin.

cholera vaccine.

cidofovir.

cisatracurium.

neomycin PO.

onabotulinumtoxinA.

Typical Dosage

Kindly do not self administer.


Storage Requirements

Store below 30°C


Effects Of Overdose

Consult a doctor before taking any medicines.


Expert Advice

Colicraft 1Million IU Injection is an antibiotic that is usually only given in the hospital for serious infections.

It is given by injection or drip (infusion) into a vein usually over 30-60 minutes.

Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.

Diarrhea may occur as a side effect. Inform your doctor if it doesn't stop or if you find blood in your stools.

Your doctor may get regular blood tests done to monitor the level of the medicine in your blood.


How To Use

Your doctor or nurse will give you this medicine. Kindly do not self administer.


FAQs

Q. What should I tell my doctor before taking Colicraft 1Million IU Injection?

Before taking Colicraft 1Million IU Injection, you must tell your doctor if you have or ever had any problems related to your kidneys or lungs (such as asthma). Let your doctor know about all the other medicines you are taking because they may affect, or be affected by, this medicine.

Q. How is Colicraft 1Million IU Injection administered?

Colicraft 1Million IU Injection should be administered under the supervision of a trained healthcare professional or a doctor only and should not be self-administered. The dose will depend on the condition you are being treated for and will be decided by your doctor. Follow your doctor’s instructions carefully to get maximum benefit from Colicraft 1Million IU Injection.

Q. Who should not use Colicraft 1Million IU Injection?

Use of Colicraft 1Million IU Injection should be avoided in patients who are allergic to Colicraft 1Million IU Injection or any of its components. However, if you are not aware of any allergy or if you are using Colicraft 1Million IU Injection for the first time, consult your doctor.

Q. Can I take Colicraft 1Million IU Injection in pregnancy?

Enough evidence is not available to provide clarity on the use of Colicraft 1Million IU Injection in pregnancy. However, if you are pregnant or planning to conceive, consult your doctor before taking Colicraft 1Million IU Injection. You may take it only if prescribed by your doctor.