Manufacturer: Sun Pharmaceutical Industries Ltd
Salt Composition : Irinotecan(40mg)
Colotecan 40mg Injection is given as an IV infusion into vein by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.The most common side effects of this medicine include fatigue, nausea, vomiting, weakness, and hair loss. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Inform your doctor if you notice fever, sore throat, and continuous episodes of diarrhea. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.
Colotecan 40mg Injection is an anti-cancer medication. It works by suppressing the activity of an enzyme (topoisomerase I) involved in DNA multiplication of the cancer cells. This slows the growth of cancer cells and eventually kills them.
The clinical pharmacokinetics of irinotecan (CPT11) can be described by a 2 or 3 compartment model, a mean terminal half-life of 12 hours, a volume of distribution at steady state of 168 l/m2 and a total body clearance of 15 l/m2/h. Irinotecan is 65% bound to plasma proteins.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Colotecan
Fatigue
Nausea
Vomiting
Weakness
Hair loss
Fever
Anemia (low number of red blood cells)
Diarrhea
Decreased white blood cell count (neutrophils)
Decreased appetite
Mucosal inflammation
If you are suffering from any of the following diseases, you should not take Irinotecan unless your doctor advises you to do so -
Liver Disease
Herpes
Neutropenia
Dehydration
Diarrhea (Loose Motions)
Diabetes
Colotecan 40mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Colotecan 40mg Injection. Please consult your doctor.
Colotecan 40mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Use with caution
Below 9years: Contraindicated
Irinotecan is indicated for patients with metastatic carcinoma of the colon or rectum whose disease has recurred or progressed following initial fluorouracil-based therapy.
Some medicines can affect the way Colotecan Injection works or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
Tell your doctor about all medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
Particular care should be taken if you are taking medicines used to treat fits/seizures (carbamazepine, phenobarbital, phenytoin, and fosphenytoin), medicines used to treat fungal infections (ketoconazole, itraconazole, voriconazole and posaconazole), medicines used to treat bacterial infections (clarithromycin, erythromycin, and telithromycin), medicines used to treat tuberculosis (rifampicin and rifabutin), St. John's Wort (a herbal medicine), live attenuated vaccines, medicines used to treat HIV (indinavir, atazanavir, and others), medicines used to suppress your body’s immune system to prevent transplant rejection (cyclosporine and tacrolimus), medicines used to treat cancer (regorafenib, crizotinib, idelalisib, cetuximab, and apalutamide), vitamin K antagonists (blood thinners like warfarin), medicines used to relax muscles used during general anaesthesia and surgery (suxamethonium), 5-fluorouracil/folinic acid, and bevacizumab (a blood vessel growth inhibitor).
Avoid taking laxatives and stool softeners while taking Colotecan Injection.
Kindly do not self administer.
Store below 30°C
If you miss a dose of Colotecan 40mg Injection, please consult your doctor.
Consult a doctor before taking any medicines.
Colotecan 40mg Injection is used in combination with other medicines for the treatment of metastatic cancer of the colon and rectum.
It is given via a drip into a vein (intravenous infusion).
It may cause dizziness and visual disturbances. Do not drive or do anything that requires mental focus until you know how it affects you.
Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
Your doctor may get regular blood tests done to monitor your blood cells, kidney and liver function during treatment with this medicine.
Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash.
Inform your doctor if you notice passage of blood in stools or experience dizziness or faintness, continuous episodes of nausea, vomiting, diarrhea or fever.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
