Manufacturer: Biological E Ltd
Combe Five Suspension for Injection is used for active immunization. Diphtheria toxoid is available in combination with tetanus toxoid (T) as DT (for useThe dangers of developing pertussis, tetanus, or diphtheria far outweigh the risks of vaccination. Mild side effects may include Pain, redness, or swelling in the arm where the shot was given as well as mild fever.
It provides active immunization against five severe diseases namely Diphtheria, Haemophilus influenzae type b, Hepatitis-B, Pertussis, and Tetanus. It boosts the immune system and produces protective antibodies against these diseases.
Diphtheria toxin kills cells by inhibiting eukaryotic protein synthesis, and its mechanism of action has been extensively characterized. This potent toxin inactivates elongation factor (EF-2) required for protein synthesis.Human clostridium tetani toxoid immune globulin prevents tetanus toxoid from damaging tissue and producing the symptoms associated with tetanus Label. The immune globulin binds to tetanus toxiod, interfering with the normal interaction of the toxoid with human tissue.Pertussis toxin (PT) utilizes a retrograde transport pathway through the Golgi complex and endoplasmic reticulum (ER) to gain entry to the cell cytosol. ATP binding to PT B oligomer (PTB) in the ER promotes holotoxin dissociation for further transport of the active subunit.Hepatitis B vaccine recombinant is used to prevent infection by the hepatitis B virus. The vaccine works by causing your body to produce its own protection (antibodies) against the disease.Haemophilus b polysaccharide vaccine is an active immunizing agent used to prevent infection by Haemophilus influenzae type b (Hib) bacteria. The vaccine works by causing your body to produce its own protection (antibodies) against the disease.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Combe Five
Neurological disturbances
Pain
Fever
Flushing (sense of warmth in the face, ears, neck and trunk)
Decreased blood pressure
Erythema (skin redness)
Slow heart rate
Tenderness
Hives
Joint pain
Swelling of lymph nodes
Injection site reactions (pain, swelling, redness)
Acute allergic reactions
Headache
Muscle pain
Guillain-Barré syndrome
Soreness
Swelling
Fatigue
Decreased appetite
Inflammation of the nose
Allergic reaction
Diarrhea
Injection site pain
Injection site swelling
Loss of appetite
Restlessness
Unusual crying
Vomiting
If you are suffering from any of the following diseases, you should not take Diphtheria Toxoid + Haemophilus Influenzae Type B Capsular Polysaccharide + Hepatitis B + Pertussis Toxoid + Tetanus Toxoid unless your doctor advises you to do so -
Guillain-Barre Syndrome
Bleeding
Agammaglobulinemia
Cancer
Guillain-Barre Syndrome
Hemophilia
Heart Disease
Hemophilia
Kidney Disease
Fever
Cancer
Fever
Allergy
Agammaglobulinemia
Cancer
Infections
Diphtheria Toxoid + Tetanus Toxoid + Pertussis Toxoid + Hepatitis B Vaccine + Haemophilus b polysaccharide should be used during pregnancy only when suggested by the doctor. Please consult your doctor before taking Diphtheria Toxoid + Tetanus Toxoid + Pertussis Toxoid + Hepatitis B Vaccine + Haemophilus b polysaccharide.
It is not known if Diphtheria Toxoid + Tetanus Toxoid + Pertussis Toxoid + Hepatitis B Vaccine + Haemophilus b polysaccharide is affected by alcohol intake. Please consult your doctor for more information.
Diphtheria Toxoid + Tetanus Toxoid + Pertussis Toxoid + Hepatitis B Vaccine + Haemophilus b polysaccharide should be used during breastfeeding only when advised by the doctor. However, please consult your doctor before taking Diphtheria Toxoid + Tetanus Toxoid + Pertussis Toxoid + Hepatitis B Vaccine + Haemophilus b polysaccharide if you are a breastfeeding mother.
Use with caution
Below 9years: Contraindicated
Diphtheria Toxoid + Tetanus Toxoid + Pertussis Toxoid + Hepatitis B Vaccine (rDNA) + Haemophilus Influenzae Type B Capsular Polysaccharide is a combination of five vaccines. It helps develop immunity by initiating a mild infection in the body. This type of infection does not cause illness but stimulates the body's immune system to produce antibodies (proteins) to protect against any future infections.
Before using Diphtheria Toxoid + Tetanus Toxoid + Pertussis Toxoid + Hepatitis B Vaccine + Haemophilus b polysaccharide, let your doctor know if you have any allergic reactions to vaccines, immune system disorders like Guillain-Barre syndrome, HIV infection, high fever, and fits.
Kindly do not self administer.
Store below 30°C
Do not panic. If you miss a schedule of Combe Five Suspension for Injection, do consult your child’s doctor and get your child vaccinated as soon as possible.
Consult a doctor before taking any medicines.
Diphtheria Toxoid
• For DPT vaccine, always follow the compulsory schedule of 5 doses starting from 6 weeks age of a child.Inform your doctor, if you have taken diphtheria toxoid vaccine within 5 years.
• Inform your doctor, if you are suffering from blood disorders, sudden temporary loss of movements (Guillain Barre Syndrome), or if you have a poor body defence system.
• Do not drive of operate machinery after the injection, as the combination vaccines may cause dizziness.
• Seek immediate medical attention if you experience severe allergic reaction such as tightness in chest, difficulty breathing, fainting, fits, tingling or weakness in hands and feet, severe and persistent swelling, redness and pain on injection site.
• Should not be given to patients allergic to diphtheria toxoids, any of the components of the combination vaccines or any of its ingredients.
• Should not be given to patients with acute severe illness with high fever.
• Should not be given to patients with a history of severe allergic reaction after vaccination with any other diphtheria toxoid-containing vaccines.
Tetanus Toxoid
Do not take tetanus toxoid if you are allergic to it or any of the other ingredient of this injection.
Consult your doctor before taking tetanus toxoid if you are pregnant, breast-feeding or planning for a pregnancy; or undergoing radiation or chemotherapy.
Doctor’s advice should be considered in case of patients with following history of disease conditions: seizures (fits); fever, infection, bleeding disorder, low platelet levels or weak immune system due to HIV infection or AIDS.
Take special precautions while using tetanus toxoid if you had severe pain and swelling or bleeding at previous vaccination site.
Hepatitis B Vaccine (rDNA)
Inform your doctor before taking the vaccine if you have a weakened immune system due to cancer, use of anti-cancer drugs, dialysis or HIV infection.
Inform your doctor before taking the vaccine if you are old, obese or if you smoke.
Tell your doctor if you fainted during earlier vaccination with hepatitis B or if you have problems with blood clotting or if you have hepatitis B infection or live in an area prone to hepatitis B infection.
Do not drive or operate heavy machinery as the vaccine may make you feel dizzy.
Tell your doctor if you are pregnant, planning to become pregnant or are breastfeeding.
Do not take if allergic to hepatitis B or any other vaccines or any of its ingredients.
Do not take if having fever.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Diphtheria Toxoid
Q. Is diphtheria toxin an endotoxin?
No, diphtheria toxin is an exotoxin and not an endotoxin
Q. Is diphtheria toxin a protein?
Yes, diphtheria toxin is an extracellular protein of the bacteria Corynebacterium diphtheriae.
Tetanus Toxoid
Q. What type of immunity does Tetanus Toxoid provide?
Tetanus Toxoid provides artificial active immunity. This type of immunity is generated when a dead or weakened version of the disease enters the body, causing an immune response which includes the production of antibodies. Vaccination with Tetanus Toxoid helps to prevent the deadly disease, tetanus.
Q. What is a booster dose or booster vaccine or booster shot?
A booster dose or booster vaccine or booster shot is an additional dose of a vaccine that may have to be administered periodically (usually once every few years) after completing the initial or primary vaccination against certain diseases. This helps to ‘boost’ your immunity against such diseases so that you are adequately protected against them.
Q. Is there a cure for tetanus?
There is no cure for tetanus once a person develops symptoms, just supportive treatment and management of complications can be done in a hospital setup. The best way to treat tetanus is its prevention through vaccination or immunization.
Q. How long does it take to show signs of tetanus after being exposed?
After being exposed, the incubation period varies from 3 to 21 days, with an average of eight days. The further the injury site is from the central nervous system, the longer the incubation period. The shorter the incubation period, the higher the risk of death.
Q. What are the symptoms of tetanus? How does Tetanus Toxoid work?
Tetanus symptoms involve tightening of muscles of the body and causing a locked jaw, thus making it impossible to breathe, open the mouth to eat or swallow. Tetanus Toxoid works by helping the body produce substances that resist infection from bacteria causing tetanus.
Q. Who should get Tetanus Toxoid?
Tetanus Toxoid should be given to everyone, even to children as early as 2 months of age. Booster doses are recommended for everyone almost every 10 years. Consult your doctor if you have any doubts regarding the vaccination.
Q. What if I miss a dose of Tetanus Toxoid?
If a scheduled vaccination booster dose of Tetanus Toxoid is missed, talk to your doctor and arrange another visit as soon as possible.
Q. Is Tetanus Toxoid a safe vaccine?
Various studies and trials have shown that Tetanus Toxoid is a safe and effective vaccine. Hence, it has been approved for use and recommended by various medical organizations and doctors all around the world. By preventing life-threatening diseases like tetanus, it has proven to be of immense benefit. Tetanus Toxoid is also well tolerated. Any side effects that may be seen with this vaccine are usually minor and tend to resolve quickly.
Hepatitis B Vaccine (rDNA)
Q. Who all should get vaccinated with Hepatitis B Vaccine (rDNA)?
Everyone should get vaccinated with Hepatitis B Vaccine (rDNA). All infants, beginning at birth, all children aged up to 19 years who have not been vaccinated previously and persons with chronic liver disease, other than hepatitis B (e.g. cirrhosis, fatty liver disease, etc.) or those with HIV infection must also get this vaccination. Additionally, suspected sexual partners of hepatitis B-positive persons or victims of sexual assault (rape) or abuse are also advised to get vaccinated with Hepatitis B Vaccine (rDNA) to be protected against Hepatitis B infection.
Q. Is hepatitis B infection curable?
No. In most cases, the symptoms of hepatitis B infection is resolved within 4-8 weeks but person remain infected for lifetime. In some cases, however, symptoms may persist for a longer time (chronic infection)
Q. Is hepatitis B infection fatal or life-threatening?
Yes. Hepatitis B infection symptoms, if present for a longer time, may cause chronic infection, liver cirrhosis or liver cancer and can also be life threatening.
Q. Is hepatitis B infection contagious?
Yes. Hepatitis B virus infection is contagious.
Q. Does it spread through saliva or sharing of food?
Yes. Hepatitis spreads through contact with the body fluids including saliva, blood, semen etc. of the infected person.
Q. Does hepatitis B vaccine cause fever?
Mild fever may occur after hepatitis B vaccine administration. Contact your doctor if your fever worsens or does not go away.
