Manufacturer: Allergan India Pvt Ltd
Salt Composition : Timolol(5mg), Brimonidine(2mg)
Combigan Ophthalmic Solution is to be used only in the affected eye in the dose and duration as advised by the doctor. Wash your hands before using this medicine. Check the label thoroughly for directions before use. Do not skip any doses and finish the full course of treatment even if you feel better.
Brimonidine exerts its ocular hypotensive effect by decreasing aqueous humor production and increasing uveoscleral outflow, while timolol acts by reducing aqueous humor production. Combigan has a fast onset of action, and the peak IOP lowering effect occurs at two hours after administration.
Timolol and its metabolites are mainly found excreted in the urine. Timolol half-life was measured at 2.9 ± 0.3 h hours in a clinical study of healthy volunteers. One pharmacokinetic study in healthy volunteers measured the total plasma clearance of timolol to be 557 ± 61 ml/min
After ocular administration of either a 0.1% or 0.2% solution, plasma concentrations peaked within 0.5 to 2.5 hours and declined with a systemic half-life of approximately 2 hours. In humans, systemic metabolism of brimonidine is extensive. It is metabolized primarily by the liver.
Application site reactions (burning, irritation, itching and redness)
Blurred vision
overactive thyroid gland.
diabetes.
low blood sugar.
myasthenia gravis, a skeletal muscle disorder.
complete heart block.
partial heart block.
sinus bradycardia.
sudden and serious symptoms of heart failure called acute decompensated heart failure.
Brimonidine is also contraindicated in patients with hypersensitivity to any component of the medication, and it should not be used in children under the age of 2 because there have been reports of apnea, bradycardia, hypothermia, hypotonia, lethargy, and unresponsiveness in infants receiving brimonidine treatment
Information regarding the use of Combigan Ophthalmic Solution during pregnancy is not available. Please consult your doctor.
No interaction found/established
Information regarding the use of Combigan Ophthalmic Solution during breastfeeding is not available. Please consult your doctor.
brimonidine tartrate/timolol maleate ophthalmic solution 0.2%/0.5% is an alpha-adrenergic receptor agonist with a beta-adrenergic receptor inhibitor indicated for the reduction of elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension who require adjunctive or replacement
Some products that may interact with this drug include: beta blockers taken by mouth (such as propranolol), certain antidepressants (SSRIs such as fluoxetine, tricyclics such as amitriptyline), digoxin, epinephrine, fingolimod, high blood pressure medications (such as clonidine, methyldopa), quinidine.
Check the label for directions before use. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid. Wipe off extra liquid.
Store below 30°C
If you miss a dose of Combigan Ophthalmic Solution, skip it and continue with your normal schedule. Do not double the dose.
Consult a doctor before taking any medicines
Combigan Ophthalmic Solution is a combination of two medicines that lowers high pressure in the eye and reduces the risk of vision loss.
Apply pressure on the corner of the eye (close to the nose) for about 1 minute, immediately after instilling the drop.
If you wear soft contact lenses, remove them before putting in these eye drops and wait at least 15 minutes before putting your lenses back in.
Do not touch the tip of the dropper to any surface, or to your eye, to avoid contaminating the eye drops.
Wait for at least 5-10 minutes before delivering the next medication in the same eye to avoid dilution.
It may cause short term blurring of vision when first used. Use caution before driving or using machines.
It may cause temporary burning or itching sensation in the eye. Inform your doctor if this does not go away.
Make sure to use within 4 weeks of opening the bottle.
This medicine is for external use only. Take it in the dose and duration as advised by your doctor. Check the label for directions before use. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid. Wipe off extra liquid.
Q. How to use Combigan Ophthalmic Solution?
Wash your hands before applying Combigan Ophthalmic Solution to avoid contamination, and do not touch the tip of the dropper. If you wear contact lenses, remove them before using Combigan Ophthalmic Solution. For applying Combigan Ophthalmic Solution, tilt your head back, look up, and pull down the lower eyelid to make a pouch and then put the drops in the pouch.
Q. Can Combigan Ophthalmic Solution be stopped when symptoms are relieved?
No, Combigan Ophthalmic Solution should be continued as advised by the doctor. If any problems are experienced due to the use of Combigan Ophthalmic Solution, consult the doctor for re-evaluation.
Q. Can the use of Combigan Ophthalmic Solution cause blurry vision?
Combigan Ophthalmic Solution can blur your eyes for a short period of time. Avoid driving or operating machinery just after using Combigan Ophthalmic Solution.
Q. What are the instructions for the storage and disposal of Combigan Ophthalmic Solution?
Keep this medicine in the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
