Manufacturer: Zydus Cadila
Salt Composition : Fluticasone Propionate(50mcg), Azelastine(140mcg)
Combinase AQ Nasal Spray should be used as you have been advised by your doctor. Do not use it more often or for longer than recommended. Normally you should blow your nose gently before using it, keep one nostril closed while applying the medicine into the other, and then sniff hard to make sure it reaches deep into the nose. Then repeat for the other nostril. It provides relief very quickly and can last for several hours. If you use this medicine too often or for too long, it may worsen your symptoms rather than improve them.
Fluticasone propionate works through an unknown mechanism to affect the action of various cell types and mediators of inflammation 10. Fluticasone propionate activates glucocorticoid receptors and inhibits lung eosinophilia in rats
Azelastine antagonizes the actions of histamine, resulting in the relief of histamine-mediated allergy symptoms. Onset of action occurs within 15 minutes with intranasal formulations and as quickly as 3 minutes with ophthalmic solutions.
For inhaled fluticasone propionate (FP), oral bioavailability is negligible due both to low absorption from the gastrointestinal tract and high hepatic first-pass metabolism. Therefore, any systemic effects of this drug arise from lung absorption
Approximately 75% of an oral dose of radiolabeled azelastine hydrochloride was excreted in the feces with less than 10% as unchanged azelastine. Azelastine is oxidatively metabolized to the principal active metabolite, desmethylazelastine, by the cytochrome P450 enzyme system.
Taste change
Nosebleeds
Headache
Cough
Upper respiratory tract infection
Dryness in mouth
Nasopharyngitis (inflammation of the throat and nasal passages)
Sinus inflammation
Stomach discomfort
Fungal infection of oropharynx
Tremors
Palpitations
Voice change
active tuberculosis.
herpes simplex infection of the eye.
thrush.
an infection due to a parasite.
insufficiency of the hypothalamus and pituitary gland.
wide-angle glaucoma.
clouding of the lens of the eye called cataracts.
osteoporosis, a condition of weak bones.
active tuberculosis.
inactive tuberculosis.
herpes simplex infection of the eye.
a nasal fungal infection due to Candida.
an infection due to a parasite.
decreased function of the adrenal gland.
increased pressure in the eye.
wide-angle glaucoma.
Combinase AQ Nasal Spray may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
No interaction found/established
Combinase AQ Nasal Spray is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Fluticasone propionate is indicated as an inhaler for the treatment and management of asthma by prophylaxis Labelas well as inflammatory and pruritic dermatoses 9. Fluticasone propionate nasal spray is indicated for managing allergic and nonallergic rhinitis
Intranasal azelastine is indicated for the symptomatic treatment of seasonal allergic rhinitis in patients 5 years and older and for the symptomatic treatment of vasomotor rhinitis in patients 12 years and older.
aspirin.
"azole" antifungals
ceritinib.
cobicistat.
desmopressin.
esketamine.
HIV protease inhibitors
Buprenorphine Buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Bupropion Bupropion may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Check the label for directions before use. Insert the bottle tip into one nostril and close the other nostril. Direct the spray towards the sides of your nostril, away from the cartilage dividing the two sides of your nose. As you spray, breath gently and keep the head upright. Repeat the same process for the other nostrils.
Store below 30°C
If you miss a dose of Combinase AQ Nasal Spray, use it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
The right way to use the nasal spray:
Shake the bottle before using the medicine.
Clean your nose thoroughly before using the medicine.
Insert the bottle tip into one nostril and close the other nostril.
Direct the spray towards the sides of your nostril, away from the cartilage dividing the two sides of your nose.
Breathe out gently through your mouth and repeat the same process for the other nostril.
Avoid deep breathing as it will cause medication to go back to the throat and make it less effective.
Inform your doctor if you have an infection,injury or ulceration in the inside of the nose as Combinase AQ Nasal Spray can increase the risk of nose bleed and ulceration.
Do not share the bottle with anyone else so that you do not spread germs.
The right way to use the nasal spray:
Shake the bottle before using the medicine.
Clean your nose thoroughly before using the medicine.
Insert the bottle tip into one nostril and close the other nostril.
Direct the spray towards the sides of your nostril, away from the cartilage dividing the two sides of your nose.
Breathe out gently through your mouth and repeat the same process for the other nostril.
Avoid deep breathing as it will cause the medication to go back to the throat and make it less effective.
Do not share the bottle with anyone else so that you do not spread germs.
Use this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Insert the bottle tip into one nostril and close the other nostril. Direct the spray towards the sides of your nostril, away from the cartilage dividing the two sides of your nose. As you spray, breath gently and keep the head upright. Repeat the same process for the other nostrils.
Q. Can the use of Combinase AQ Nasal Spray cause sleepiness?
Yes, Combinase AQ Nasal Spray can make you feel sleepy. Avoid driving, operating machinery, working at heights or participating in potentially dangerous activities till you know how this medicine affects you.
Q. How to use Combinase AQ Nasal Spray?
Before using Combinase AQ Nasal Spray, make sure you clean your nose by blowing it gently. Shake the bottle and spray the medicine into your nose. You should keep your head down while using Combinase AQ Nasal Spray.
Q. What are the instructions for the storage and disposal of Combinase AQ Nasal Spray?
Keep this medicine in the packet or the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
