Combither AT 120mg (Injection)

Prescription
Prescription Required: Consult the Doctor & Get Your ePrescription

Combither AT 120mg Injection is administered as an injection by a healthcare professional. Kindly do not self-administer. It is given in cases where oral administration is not possible.



Basic Information

Mechanism Of Action

Artesunate is an artemisinin derivative that is metabolized to DHA, which generates free radicals to inhibit normal function of Plasmodium parasites. It has a short duration of action due to its short half life, and a moderate therapeutic index.

Pharmacokinets

AS is metabolized through esterase-catalyzed hydrolysis to yield its active metabolite, DHA [17]; this conversion occurs quickly following IV AS administration as indicated by the rapid decline in AS concentrations in the early post-dose period

Side Effects

Headache

Dizziness

Weakness

Loss of appetite

Injection site reactions (pain, swelling, redness)

Contra Indications

Known contraindications include a previous severe allergic reaction to artesunate. Drugs that should be avoided while on artesunate are the drugs that inhibit the liver enzyme CYP2A6. These drugs include amiodarone, desipramine, isoniazid, ketoconazole, letrozole, methoxsalen and tranylcypromine.


Pregnancy Related Information

Combither AT 120mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.


Product And Alcohol Interaction

It is not known whether it is safe to consume alcohol with Combither AT 120mg Injection. Please consult your doctor.


Breast Feeding Related Information

Combither AT 120mg Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.


Indications

Artesunate for Injection is indicated for the initial treatment of severe malaria in adult and pediatric patients. Treatment of severe malaria with Artesunate for Injection should always be followed by a complete treatment course of an appropriate oral antimalarial regimen [see Dosage and Administration

Interactions

Artesunate has no listed moderate interactions with other drugs. Artesunate has no listed mild interactions with other drugs. This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use

Typical Dosage

Kindly do not self administer.


Storage Requirements

Store below 30°C


Effects Of Missed Dosage

If you miss a dose of Combither AT 120mg Injection, please consult your doctor.


Effects Of Overdose

Consult a doctor before taking any medicines

Expert Advice

Combither AT 120mg Injection is used in the treatment of malaria.

Inform your doctor if you are allergic to Combither AT 120mg Injection.

Do not start or continue Combither AT 120mg Injection and consult your doctor if you are in the first 3 months of pregnancy or if you are breastfeeding.

Do not drive or operate machinery after taking it because you may feel sleepy.

Inform your doctor if you notice flu-like symptoms such as chills, fever, muscle pains and any changes in a heartbeat.

You may be asked for a regular blood test once a week while taking this medicine. 

How To Use

Your doctor or nurse will give you this medicine. Kindly do not self administer.


FAQs

Q. Who should not use Combither AT 120mg Injection?

Use of Combither AT 120mg Injection should be avoided in patients who are allergic to Combither AT 120mg Injection or any of its components. However, if you are not aware of any allergy or if you are using Combither AT 120mg Injection for the first time, consult your doctor.

Q. What should I tell my doctor before starting treatment with Combither AT 120mg Injection?

Before starting treatment with Combither AT 120mg Injection, inform your doctor if you have any other health conditions like a kidney- or heart-related problem. This is because certain medical conditions may affect your treatment and you may even need dose modifications. Also, let your doctor know about all the other medicines you are taking because they may affect, or be affected by, this medicine. Inform your doctor if you are pregnant or breastfeeding.

Q. Is Combither AT 120mg Injection safe?

Combither AT 120mg Injection is safe if used in the dose and duration advised by your doctor. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.

Q. How is Combither AT 120mg Injection administered?

Combither AT 120mg Injection should be administered under the supervision of a trained healthcare professional or a doctor only and should not be self-administered. The dose will depend on the condition you are being treated for and will be decided by your doctor. Follow your doctor’s instructions carefully to get the maximum benefit from Combither AT 120mg Injection.