Manufacturer: Sun Pharmaceutical Industries Ltd
Salt Composition : Salmeterol(25mcg), Fluticasone Propionate(250mcg)
Your doctor will tell you how often you need to use your inhaler. The effect of this medicine may be noticeable after a few days but will only reach its maximum after a few weeks. This medicine must be used regularly to be effective, so go on taking it even if you don't have any symptoms. That means it’s doing its job. If you stop taking it your asthma and chronic obstructive pulmonary disorder (COPD) may get worse. It should not be used to relieve sudden asthma attacks. If an asthma attack occurs, use your quick-relief inhaler (reliever). To get the benefit from this medicine you need to make sure you get your inhaler technique right, otherwise, it does not work as well.
Inhaled salmeterol belongs to a group of drugs called beta-2 agonists. These drugs stimulate beta-2 receptors present in the bronchial musculature. This causes them to relax and prevent the onset and worsening of symptoms of asthma.
Fluticasone propionate works through an unknown mechanism to affect the action of various cell types and mediators of inflammation 10. Fluticasone propionate activates glucocorticoid receptors and inhibits lung eosinophilia in rats
Salmeterol is an inhaled long-acting selective beta(2)-adrenoceptor agonist that is commercially available as the xinafoate (1-hydroxy-2-naphthoic acid) salt of the racemic mixture of the two optical isomers, (R)- and (S)-, of salmeterol. It acts locally in the lung through action on beta2 receptors.
For inhaled fluticasone propionate (FP), oral bioavailability is negligible due both to low absorption from the gastrointestinal tract and high hepatic first-pass metabolism. Therefore, any systemic effects of this drug arise from lung absorption
Nausea
Vomiting
Respiratory tract infection
Fungal infection of mouth
Sore throat
Headache
Hoarseness of voice
Cough
Musculoskeletal (bone, muscle or joint) pain
Increased heart rate
While not strictly contraindications, salmeterol use requires caution in patients with an existing cardiovascular disorder, convulsive disorder, hepatic impairment, diabetes mellitus, hyperthyroidism/thyrotoxicosis, or who use other CYP3A inhibitors, as this may increase toxicity and prolong the patient's QT interval.
active tuberculosis.
herpes simplex infection of the eye.
thrush.
an infection due to a parasite.
insufficiency of the hypothalamus and pituitary gland.
wide-angle glaucoma.
clouding of the lens of the eye called cataracts.
osteoporosis, a condition of weak bones.
Combitide 250 CFC Free Inhaler may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Combitide 250 CFC Free Inhaler. Please consult your doctor.
Combitide 250 CFC Free Inhaler is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
darunavir.
fosamprenavir.
indinavir.
lefamulin.
lopinavir.
nelfinavir.
ritonavir.
aspirin.
"azole" antifungals
ceritinib.
cobicistat.
desmopressin.
esketamine.
HIV protease inhibitors
Shake the inhaler. While you are breathing in from mouth, press down on the inhaler one time to release the medication and hold your breath for 10 seconds. Repeat until you have inhaled the number of puffs as suggested by the doctor.Afterwards, rinse your mouth thoroughly with water and spit it out.
Store below 30°C
If you miss a dose of Combitide 250 CFC Free Inhaler, use it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines
This medicine is for inhalation only. The tablet should not be swallowed.
It should be taken at the same time each day.
It does not work right away and should not be used to relieve sudden breathing problems. Use your rescue inhaler to control sudden difficulty in breathing.
Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake and sugarless candy may help.
Gargle with warm water after each inhalation to avoid any fungal infections in your mouth and throat.
Take the first dose of this medicine under medical supervision as it may cause wheezing or tightening of the airways (bronchospasm) immediately after using.
Your doctor may regularly monitor your blood potassium level as low oxygen level in the blood (hypoxia) and medicines such as Combitide 250 CFC Free Inhaler can lower blood potassium level.
Only miniscule amounts of Combitide 250 CFC Free Inhaler may get absorbed into the bloodstream after inhalation. Hence, serious side effects are unlikely.
Check the label for directions before use. Shake the inhaler. While you are breathing in from mouth, press down on the inhaler one time to release the medication and hold your breath for 10 seconds. Repeat until you have inhaled the number of puffs as suggested by the doctor.Afterwards, rinse your mouth thoroughly with water and spit it out.
Q. What is Combitide 250 CFC Free Inhaler prescribed for?
Combitide 250 CFC Free Inhaler is prescribed to treat Chronic Obstructive Pulmonary Disease and Asthma. The symptoms may include wheezing, shortness of breath, and breathing difficulties.
Q. Can I stop taking Combitide 250 CFC Free Inhaler when my symptoms are relieved?
No, do not stop taking Combitide 250 CFC Free Inhaler. If you stop taking Combitide 250 CFC Free Inhaler, your symptoms may come back and may lead to serious complications. Take your medicine as advised by your doctor.
Q. Will Combitide 250 CFC Free Inhaler be more effective if taken in more than recommended dose?
No, taking more of this medicine will not make it more effective, rather it can lead to increased side effects. If symptoms are not getting relieved by the recommended doses, please consult the doctor for re-evaluation.
Q. What are the instructions for storage and disposal of Combitide 250 CFC Free Inhaler?
Keep this medicine in the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
