Manufacturer: Lupin Ltd
Salt Composition : Ethambutol(200mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Combutol 200 Tablet is usually given in combination with at least one other tuberculosis medicine. It should be used in the dose and duration as advised by your doctor. This medicine may be taken with or without food, preferably at the same time every day. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early can result in treatment failure and in the development of drug-resistant tuberculosis. This can lead to serious health complications.
The mechanism of action of ethambutol is not completely known. There is evidence that the drug exerts its bacteriostatic activity by virtue of inhibition of arabinosyl transferase, an enzyme that polymerizes arabinose into arabinan and then arabinogalactan, a mycobacterial cell wall constituent
Ethambutol is mainly oxidized by an aldehyde dehydrogenase to an aldehyde metabolite, followed by conversion to the dicarboxylic acid 2,2'-(ethylinediimino)di-butyric acid. Ethambutol is 50% eliminated in the urine as the unmetabolized parent compound and 8-15% as inactive metabolites
Visual impairment
Color blindness
diabetic retinopathy, a type of damage to the eye from diabetes.
a type of joint disorder due to excess uric acid in the blood called gout.
clouding of the lens of the eye called cataracts.
sudden blindness and pain upon moving the eye.
decreased kidney function.
Combutol 200 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Combutol 200 Tablet. Please consult your doctor.
Combutol 200 Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Ethambutol is indicated in combination with other anti-tuberculosis drugs in the treatment of pulmonary tuberculosis. It has a long duration of action as it is administered daily, and a moderate therapeutic window. Patients should be counselled regarding the risk of optic neuritis and hepatic toxicity.
Avoid taking an antacid containing aluminum hydroxide (Alternagel, Maalox, Mi-Acid, Mylanta, Rulox) within 4 hours after you take ethambutol. Some antacids can make it harder for your body to absorb ethambutol
Do not chew, crush or break it. Combutol 200 Tablet may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
If you miss a dose of Combutol 200 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Combutol 200 Tablet is effective at treating tuberculosis when taken together with other antibacterial drugs.
It has to be taken for several months in order for it work properly (usually 6 months).
Take it with food to avoid stomach upset.
It can lower your blood sugar. If you have diabetes, monitor your blood sugar regularly.
Your doctor may monitor your liver function, vision and thyroid function while on treatment with this medicine.
Avoid consuming alcohol while taking this medication.
Do not stop taking Combutol 200 Tablet even if you start to feel better. Stopping early can result in treatment failure and in the development of drug-resistant tuberculosis. This can be life-threatening and lead to other serious health risks.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Combutol 200 Tablet may be taken with or without food, but it is better to take it at a fixed time.
Q. My child vomited after taking Combutol 200 Tablet. What should be done?
If your child vomited within 30 minutes of taking Combutol 200 Tablet, give the same dose again. If vomiting occurred 30 minutes after taking Combutol 200 Tablet, you need not repeat the dose. If your child vomits again after taking Combutol 200 Tablet, consult your doctor.
Q. For how long does Combutol 200 Tablet stay in your system?
Combutol 200 Tablet stays for about 24 hours in your system. This duration varies from person to person and maybe different for patients with kidney problems.
Q. Will Combutol 200 Tablet work if I have developed tuberculosis for the second time?
Yes, it will work if you had taken proper treatment and got cured when you developed tuberculosis for the first time. If you have any doubt, ask your doctor.
Q. Is it necessary to take so many TB drugs simultaneously? Is there no single medicine which can provide a cure for tuberculosis?
Yes, it is important that you take all the prescribed TB drugs together for the recommended duration, else you will not be cured. A single drug is not prescribed to treat TB because it may increase the risk of developing multi-drug resistant tuberculosis, which is very difficult to treat.
