Manufacturer: Surge Biotech Pvt Ltd
Salt Composition : Ambroxol(15mg/5ml), Guaifenesin(50mg/5ml), Menthol(2.5mg/5ml), Terbutaline(1.25mg/5ml)
Bottle of 100ml Syrup
(Inclusive of all taxes)
Coughsee AM Syrup is taken with or without food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your doctor know about all other medications you are taking as some may affect, or be affected by this medicine.
The main mechanism of action for ambroxol involves stimulation of surfactant synthesis, a complex mechanism that is not yet fully understood , but that gives ambroxol effective mucokinetic and secretagogue properties, thus promoting mucous clearance, facilitating expectoration and easing productive cough.
Guaifenesin, a mucoactive drug, acts by loosening mucus in the airways and making coughs more productive. It is used for relief of wet cough and chest congestion due to the common cold, and remains the only legally marketed expectorant in the US
Terbutaline is a bronchodilator, a medication that dilates (expands) air passages in the lungs. It attaches to beta adrenergic receptors on muscles surrounding the air passages, causing the muscles to relax and dilate the air passages. Wider air passages allow more air to flow in and out of the lungs
Menthol is a selective activator of transient receptor potential melastatin-8 (TRPM8) channels and is also a vasoactive compound. As a topical agent, it acts as a counter-irritant by imparting a cooling effect and by initially stimulating nociceptors and then desensitizing them.
Bioavailability of ambroxol administered orally is approximately 70–80%. The distribution half-life of ambroxol is 1.3 hours, metabolite is dibromoanthranilic acid (activity unspecified) and Elimination of ambroxol is biphasic, with an alpha half-life of 1.3 hours and a beta half-life of 8.8 hours
Guaifenesin is administered orally. The plasma half-life is approximately 1 hour. Guiafenesin is rapidly hydrolyzed (60% within seven hours) and then excreted in the urine, with beta-(2-methoxyphenoxy)-lactic acid as its major urinary metabolite. No unchanged drug was detected in the urine following administration
The pharmacokinetics of terbutaline has been studied after subcutaneous adminsitration of a therapeutic dose of 250 microgram in 14 patients. Short absorption half-lives of about 7 min resulted in a fast uptake of the drug.
Aside from its cold-inducing sensation capabilities, menthol exhibits cytotoxic effects in cancer cells, induces reduction in malignant cell growth, and engages in synergistic excitation of GABA receptors and sodium ion channels resulting in analgesia
Nausea
Diarrhea
Vomiting
Dizziness
Headache
Rash
Tremors
Increased heart rate
Upper abdominal pain
Urticaria
Itching
Sweating
Changes in serum aminotransferase levels
Bloating
Indigestion
Gastrointestinal Bleeding
Asthma
Smoking Addiction
High Blood Pressure
Hyperthyroidism
Diabetes
Glaucoma
glucose-6-phosphate dehydrogenase (G6PD) deficiency.
methemoglobinemia, a type of blood disorder.
abnormal heart rhythm.
decreased lung function.
seizures.
large open wound.
anemia from pyruvate kinase and G6PD deficiencies.
burns.
Coughsee AM Syrup may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Coughsee AM Syrup. Please consult your doctor.
Information regarding the use of Coughsee AM Syrup during breastfeeding is not available. Please consult your doctor.
All forms of tracheobronchitis, emphysema with bronchitis pneumoconiosis, chronic inflammatory pulmonary conditions, bronchiectasis, bronchitis with bronchospasm asthma. During acute exacerbations of bronchitis it should be given with the appropriate antibiotic.
Guaifenesin is an expectorant that is indicated for providing temporary symptomatic relief from congested chests and coughs which may be due to a cold, bronchitis, and/or other breathing illnesses
Terbutaline is indicated for prevention and reversal of bronchospasm in patients at least 12 years old, with asthma and reversible bronchospasm associated with bronchitis and emphysema
This medication is used to treat minor aches and pains of the muscles/joints (such as arthritis, backache, sprains). Menthol works by causing the skin to feel cool and then warm. These feelings on the skin distract you from feeling the aches/pains deeper in your muscles and joints.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Medicine
Medicine
The metabolism of this medication may be decreased when combined with the following drugs: Warfarin, 4-hydroxycoumarin, 5-androstenedione, 6-O-benzylguanine.
Interaction with Disease
Disease
It should be used with extreme caution in case of patients suffering from gastric ulcers or with a history of the same as it will only lead to the worsening of the situation
Menthol topical has no listed severe interactions with other drugs. Menthol topical has no listed serious interactions with other drugs. Menthol topical has no listed moderate interactions with other drugs. Menthol topical has no listed mild interactions with other drugs.
Measure it with a measuring cup and take it by mouth. Shake well before use. Coughsee AM Syrup may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
Consult a doctor before taking any medicines
Coughsee AM Syrup relieves cough associated with bronchitis, bronchial asthma, emphysema and other broncho-pulmonary disorders.
It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
If you are diabetic, monitor your blood glucose regularly while taking this medicine.
Inform your doctor if you have a history of thyroid or heart disease.
Stop taking Coughsee AM Syrup and inform your doctor if your cough persists for more than 1 week, tends to recur, or is accompanied by a fever, rash or persistent headache.
Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Coughsee AM Syrup may be taken with or without food, but it is better to take it at a fixed time.
Q. Will a higher than the recommended dose of Coughsee AM Syrup be more effective?
No, taking higher than the recommended dose may not be more effective, rather it may increase the chances of having increased side effects. If you do not find any relief in your symptoms while taking Coughsee AM Syrup, please consult your doctor.
Q. In which type of cough will the doctor prescribe Coughsee AM Syrup?
Coughsee AM Syrup is indicated in the treatment of a cough that is associated with excessive mucus secretion.
Q. Are there any contraindications associated with use of Coughsee AM Syrup?
It is not recommended to use Coughsee AM Syrup if you have hypersensitivity to any of the components of the formulation. Avoid the medication if you have pre-existing ischaemic heart disease, significant risk factors for ischaemic heart disease and gastric ulceration.
Q. What are the instructions for the storage and disposal of Coughsee AM Syrup?
Keep this medicine in the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
