Manufacturer: Marc Laboratories Pvt Ltd
Salt Composition : Rifampicin(450mg), Isoniazid(300mg), Ethambutol(800mg)
Coxwin 3 Tablet is a prescription medicine and it is to be taken as suggested by the doctor. It should be taken in an empty stomach and take it at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as this may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The course of the treatment must be completed even if you feel better. Sudden discontinuation of the treatment may affect the potency of the medicine. The medicine may take some to show its effects on the symptoms. However, it is advised to consult the doctor if you feel an aggravation of the condition or if your condition does not improve.
Coxwin 3 Tablet is a combination of three medicines: Rifampicin, isoniazid and ethambutol, which treats tuberculosis. Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by TB bacteria to make essential proteins and to reproduce, while isoniazid prevents these bacteria from forming their own protective covering. Together, they kill the bacteria and eradicate the infection. Ethambutol, on the other hand works by slowing the growth of these bacteria.
Approximately 80% of rifampicin is transported in blood bound to plasma proteins, mainly albumin. Rifampicin is well distributed, although to a different degree, in the various tissues of the human body. Probably in the hepatocyte, rifampicin undergoes a process of desacetylation.Isonicotinyl hydrazine or isoniazid (INH) has been the mainstay of TB treatment and prevention in both adults and children. When given orally in the fasted state, INH is rapidly absorbed with the maximum concentration (Cmax) occurring 1–2 hours post-dose. Food delays and decreases the extent of absorption.Ethambutol pharmacokinetics has been previously associated with many factors including malnutrition, HIV infection, age, and sex [12, 42, 48–50]. In our cohort, age was found to affect ethambutol clearance, with increasing age leading to lower clearance at a decrease rate of 1.41% per year.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Coxwin 3
Nausea
Vomiting
Rash
Fever
Dark colored urine
Sweating
Increased sputum production
Salivation
Watery eyes
Increased liver enzymes
Jaundice
Visual impairment
Increased uric acid level in blood
Gout
Peripheral neuropathy (tingling and numbness of feet and hand)
Hypersensitivity to Coxwin 3 Tablet is a contraindication. In addition, Coxwin 3 Tablet should not be used if you have the following conditions:
Alcohol
Allergic reactions
Children aged below 3 years
Hypersensitivity
Lactation
Optic neuritis
Porphyria
Pregnancy
Severe hepatic disease
Severe liver problems
Coxwin 3 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Consuming alcohol while taking Coxwin 3 Tablet may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
Coxwin 3 Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Use with caution
Below 9years: Contraindicated
Rifampicin+Isoniazid+Ethambutol is used in the treatment of tuberculosis.Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by TB bacteria to make essential proteins and to reproduce, while isoniazid prevents these bacteria from forming their own protective covering. Together, they kill the bacteria and eradicate the infection. Ethambutol, on the other hand works by slowing the growth of these bacteria.
If you use other drugs or over the counter products at the same time, the effects of Coxwin 3 Tablet may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Coxwin 3 Tablet may interact with the following drugs and products:
Aluminium Hydroxide
Aprepitant
Bromazepam
Citalopram
Clopidogrel
Enalapril
Eplerenone
Halothane
Imatinib
Imidapril
Do not chew, crush or break it. Coxwin 3 Tablet is to be taken empty stomach.
Store below 30°C
If you miss a dose of Coxwin 3 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
It is best to take the medicine on an empty stomach one hour before or two hours after meals.
Finish the prescribed course of medicine, even if you start to feel better. Stopping it early may make the infection harder to treat.
It can make birth control pills less effective so ask the doctor about using a birth control method which does not affect your hormone levels (such as a condom, diaphragm, spermicide).
It can cause temporary discoloration of your teeth, sweat, urine, saliva, and tears (red, orange, or brown color). This side effect is usually not harmful.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Coxwin 3 Tablet is to be taken empty stomach.
Avoid Coxwin 3 Tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
Q. Which is the best time to take Coxwin 3 Tablet?
Take Coxwin 3 Tablet exactly as directed by your doctor. It is best to take the medicine on an empty stomach one hour before or two hours after meals.
Q. Can the use of Coxwin 3 Tablet make birth control pills ineffective?
Yes, Coxwin 3 Tablet can make birth control pills less effective. Ask the doctor about using a birth control method which does not affect your hormone levels (such as a condom, diaphragm, spermicide).
Q. Is tuberculosis a curable disease?
Yes, tuberculosis (TB) is a curable disease and can be cured with 6–9 months of treatment. Drug-resistant forms of TB are also curable, but more difficult to treat. Treatment for drug-resistant TB can last up to 2 years and require medications that can cause serious side effects.
Q. What are the instructions for the storage and disposal of Coxwin 3 Tablet?
Keep this medicine in the packet or the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Q. Can the use of Coxwin 3 Tablet cause discoloration of the urine?
Yes, Coxwin 3 Tablet contains rifampicin which can cause temporary discoloration of your teeth, sweat, urine, saliva, and tears (red, orange, or brown color). This side effect is usually not harmful. However, discoloration of urine can be a sign of liver damage. Call your doctor if you have discoloration of urine with stomach pain, loss of appetite, and jaundice (yellowing of your skin or eyes).
Q. Can I discontinue Coxwin 3 Tablet if I feel well?
No, do not discontinue Coxwin 3 Tablet. Take the proper course of the drug that has been prescribed to you even if you begin to feel better. If you stop taking Coxwin 3 Tablet, your infection may become worse and difficult to treat. It may even result in drug-resistant TB i.e. drugs you were taking may no longer work for Tuberculosis.
Q. Can Coxwin 3 Tablet cause visual impairment?
Coxwin 3 Tablet contains Ethambutol, which may cause visual impairment. Inform the doctor immediately if you notice any changes in your eyesight.
