Manufacturer: Novartis India Ltd
Salt Composition : Imipenem(500mg), Cilastatin(500mg)
Critinem 500 mg/500 mg Injection should only be administered under the supervision of a healthcare professional. Do not miss any scheduled appointments for taking this medicine. The course of the medicine should be completed even if you feel better.The common side effects of this medicine are nausea, vomiting, diarrhea, rashes, etc. You may also experience injection site redness, swelling, and pain that goes away with time. If any of the side effects get aggravated, you must consult your doctor immediately. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help.
Critinem 500 mg/500 mg Injection works by killing bacteria which can cause serious infections. It is used to treat many different types of bacterial infections. It is given by a doctor or nurse into a vein and should not be self-administered.
Imipenem is metabolized by renal dehydropeptidase. Approximately 70% of imipenem is excreted in the urine as the parent drug. When given via IV injection imipenem has a half-life of 1 h. The apparent half-life of the IM injection ranges from 1.3-5.1 h, likely due to slower absorption form the injection site.Cilastatin is a beta-lactam antibiotic of the carbapenems class with a broad spectrum of activity. The mechanism of action is similar to the other beta-lactam antibiotics, which is to inactivate the penicillin-binding proteins (PBP) and cause cell wall lysis, or interfere with cell wall formation.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Critinem
Nausea
Vomiting
Diarrhea
Rash
If you are suffering from any of the following diseases, you should not take Cilastatin + Imipenem unless your doctor advises you to do so -
Kidney Disease
Allergy
Epilepsy
Migraine
Gastritis
Kidney Disease
Ulcerative Colitis
Heart Failure
Critinem 500 mg/500 mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Critinem 500 mg/500 mg Injection. Please consult your doctor.
Critinem 500 mg/500 mg Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Use with caution
Below 9years: Contraindicated
Imipenem+Cilastatin is used in the treatment of severe bacterial infections.Imipenem is an antibiotic. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria in the human body. Cilastatin is dehydropeptidase I inhibitor which blocks the activity of an enzyme (dehydropeptidase I) that causes breakdown of Imipenem . Hence, it helps Imipenem stay active in your body for a longer period of time.
CILASTATIN+IMIPENEM may have interaction with anti-viral (Ganciclovir), uricosurics (Probenecid), anti-epileptic (Valproic acid, Divalproex sodium), blood thinner (warfarin).
Kindly do not self administer.
Store below 30°C
If you miss a dose of Critinem 500 mg/500 mg Injection, please consult your doctor.
Consult a doctor before taking any medicines.
Critinem 500 mg/500 mg Injection is used to treat severe bacterial infections, including those acquired in hospital and those involving many different types of bacteria.
It is given by a drip into a vein (intravenous infusion) over 20 to 60 minutes.
Tell you doctor if you are allergic to penicillin as this medicine should be avoided or used with caution in penicillin allergy.
Your doctor may monitor your liver and kidney function while you are having treatment with this medication.
Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools.
Inform your doctor if you are pregnant, planning to conceive, or breastfeeding.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. For how long is Critinem 500 mg/500 mg Injection used?
Duration of treatment with Critinem 500 mg/500 mg Injection depends on the severity of your infection, which will be decided by your doctor.
Q. How long does Critinem 500 mg/500 mg Injection take to work?
Usually, Critinem 500 mg/500 mg Injection starts working soon after taking it. However, it may take some days to kill all the harmful bacteria and make you feel better.
