Manufacturer: Pfizer Ltd
Salt Composition : Crizotinib(250mg)
Crizalk 250mg Capsule should be taken with food or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Crizalk 250mg Capsule is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.
Pharmacokinetic analyses have shown crizotinib to be orally bioavailable, with a median time to maximal plasma concentration (Tmax) of approximately 4 hours and mean apparent terminal half-life of 42 hours in patients with cancer after a single 250-mg oral dose (8, 9).
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Crizalk
Nausea
Vomiting
Diarrhea
Constipation
Abdominal pain
Visual impairment
Dizziness
Taste change
Fatigue
Decreased appetite
Rash
Decreased white blood cell count (neutrophils)
If you are suffering from any of the following diseases, you should not take Crizotinib unless your doctor advises you to do so -
Drug Allergy
Bradycardia (Slow Heart Rate)
Liver Disease
Kidney Disease
Pneumonitis
Alcoholism
Crizalk 250mg Capsule is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Crizalk 250mg Capsule. Please consult your doctor.
Crizalk 250mg Capsule is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Use with caution
Below 9years: Contraindicated
Crizotinib is a tyrosine kinase inhibitor (TKI) indicated for the treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are anaplastic lymphoma kinase (ALK) or ROS1-positive as detected by an FDA-approved test.
QT prolongation.
bradycardia.
gastrointestinal perforation.
hepatic impairment.
renal impairment.
visual loss.
lung toxicity.
Crizalk 250mg Capsule may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
If you miss a dose of Crizalk 250mg Capsule, skip it and continue with your normal schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Crizalk 250mg Capsule helps in the treatment of non-small cell lung cancer that is locally advanced, or has spread to other areas of the body.
Take it at the same time each day, with or without food.
Diarrhea, nausea and vomiting may occur with Crizalk 250mg Capsule. Stay hydrated and inform your doctor if it persists.
It may cause dizziness or blurring of vision. Don't drive or do anything requiring concentration until you know how it affects you.
Inform your doctor if you experience severe stomach pain, fever, chills, shortness of breath, fast heartbeat, partial or complete loss of vision or changes in bowel habits.
Your doctor may want you to have regular blood tests to monitor your liver function while you are having treatment with this medicine.
Do not take Crizalk 250mg Capsule if you are pregnant or breastfeeding. Use reliable methods of contraception to prevent pregnancy while taking this medicine.
Take this medicine in the dose and duration as advised by your doctor. Crizalk 250mg Capsule may be taken with or without food, but it is better to take it at a fixed time.
Q. How is Crizalk 250mg Capsule administered?
Crizalk 250mg Capsule is generally administered in the form of capsules to be taken orally.
Q. What is Crizalk 250mg Capsule used for?
Crizalk 250mg Capsule is used for treating non small-cell lung cancer caused due to a mutation or defect in a gene called as anaplastic lymphoma kinase in cancer cells in patients who have not responded to previous therapies.
Q. How does Crizalk 250mg Capsule work?
Crizalk 250mg Capsule works by inhibiting an enzyme called as tyrosine kinase that transmits the signal for growth and spread of cancer cells.
