Manufacturer: Sun Pharmaceutical Industries Ltd
Salt Composition : Tacrolimus(0.1% w/w)
Crolim Power Ointment is used for external use. It should be used 2-4 times a day on the affected area or use it as suggested by the doctor. It should be applied slowly and evenly to the skin until it is rubbed in. You should not use it too often and you should not cover the treated area with a bandage or plaster. You must inform your doctor if there’s no improvement even after two weeks of treatment or if the skin gets worse.
Tacrolimus in Crolim Ointment works by suppressing the skin's immune system, thus reducing allergic reactions like redness, swelling, itching and relieving eczema.
Tacrolimus is completely metabolised prior to elimination. The mean disposition half-life is 12 hours and the total body clearance based on blood concentration is approximately 0.06 L/h/kg. The elimination of tacrolimus is decreased in the presence of liver impairment and in the presence of several drugs.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Crolim
Application site reactions (burning, irritation, itching and redness)
Diarrhea
Increased glucose level in blood
Increased thirst
Kidney damage
Liver damage
Nausea
Stomach pain
a bad infection
cancer or malignancy
diabetes
low amount of magnesium in the blood
low amount of calcium in the blood
high levels of potassium in the blood
low amount of potassium in the blood
high blood pressure
torsades de pointes, a type of abnormal heart rhythm
slow heartbeat
prolonged QT interval on EKG
chronic heart failure
abnormal EKG with QT changes from birth
severe liver disease
damage to the kidneys
coma
delirium
disorder of lymphoid tissue after transplant
pregnancy
malignant lymphoma
a rupture in the wall of the stomach or intestine
progressive multifocal leukoencephalopathy, a type of brain infection
a type of brain disorder called posterior reversible encephalopathy syndrome
kidney problems due to BK polyomavirus
pure red cell aplasia
Crolim Power Ointment may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
No interaction found/established
Crolim Power Ointment is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Use with caution
Below 9years: Contraindicated
Tacrolimus topical is used on the skin to treat moderate to severe atopic dermatitis in patients who have received other medicines that have not worked well. Atopic dermatitis is a skin condition where there is itching, redness, and inflammation, much like an allergic reaction.
TACROLIMUS may interact with immunosuppressant (ciclosporin), antibiotics (fluconazole, itraconazole, ketoconazole, clotrimazole, voriconazole, erythromycin, clarithromycin, rifampicin), antiemetic (metoclopramide), anticonvulsants (phenytoin, phenobarbital), antacids (lansoprazole, cimetidine, omeprazole), steroid (cortisone, prednisolone, methylprednisolone), antivirals (aciclovir), pain reliever (ibuprofen), an antidepressant (nefazodone), anticancer drugs (imatinib, nilotinib), anti-HIV drugs (nelfinavir, saquinavir, ritonavir).
Check the label for directions before use. Clean and dry the affected area and gently massage the ointment.
Store below 30°C
If you miss a dose of Crolim Power Ointment, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Crolim Power Ointment is effective at treating eczema (atopic dermatitis) when other treatment options have failed.
It works by decreasing itching, redness, and skin rashes.
Apply thinly, to affected areas of skin only. Clean the affected area and dry well before applying Crolim Power Ointment. Avoid contact with water after application.
Inform your doctor if there's no improvement even after two weeks of treatment, or if the skin gets worse.
Don't cover the area being treated with airtight dressings such as bandages unless directed by a doctor, as this may increase the risk of side effects.
Stop using Crolim Power Ointment and consult your doctor if your eczema becomes infected.
Continuous long-term use of the ointment should be avoided. Use as prescribed by you doctor.
This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and gently massage the ointment.
Q. What is Crolim Power Ointment used for?
Crolim Power Ointment is a medicine that modulates the immune system. It works on the immune system and mostly decreases its activity. It is used to treat moderate to severe eczema (atopic dermatitis) in adults who do not respond to steroids or develop side effects on using them. In atopic dermatitis, the skin’s immune system undergoes an overreaction and causes skin inflammation leading to itchiness, redness and dryness. Crolim Power Ointment acts on the abnormal immune response and alters it, thereby relieving the skin inflammation and itchiness.
Q. What are the side effects of Crolim Power Ointment?
Crolim Power Ointment, when applied to the skin, may cause skin irritation, burning sensation and itching at the site of application. These are usually mild to moderate in severity and normally resolve within one week of starting the treatment. Redness is also a common manifestation along with sensation of warmth, pain, altered sensation and rash at the site of application. Using it increases the patients’ increased risk of getting inflamed or infected hair follicles, cold sores, acne and generalized herpes simplex infections.
Q. Is Crolim Power Ointment ointment safe?
As compared to other immune-suppressing medicines, Crolim Power Ointment has been found to be a safe and effective short-term treatment for atopic dermatitis. When applied on the affected part of the skin, its absorption to the blood and body is minimal. Hence, the side effects are less as compared to when taken through oral route.
Q. Does Crolim Power Ointment has abuse potential?
No, Crolim Power Ointment does not have abuse potential and thus, is not a controlled substance. Controlled substances have potential for abuse so they need permission by authorities and doctor for use.
Q. Does Crolim Power Ointment cause cancer?
Long-term use of Crolim Power Ointment has been found to have increased risk of lymph node tumors called lymphoma. Some studies have found that few patients who used Crolim Power Ointment ointment or another similar medication developed skin cancer or lymphoma. Consult your doctor if you have to use Crolim Power Ointment ointment for more than 6 weeks or if your eczema symptoms have not improved or are getting worse with time during your treatment.
Q. Is Crolim Power Ointment a steroid?
No, Crolim Power Ointment is not a steroid. It is a medicine which modulates the working of the immune system. It is used in the treatment of eczema, most commonly in atopic dermatitis. An advantage of Crolim Power Ointment is that it does not cause skin thinning (atrophy) or other steroid-related side effects.
