Manufacturer: Agron Remedies Pvt Ltd
Salt Composition : Bromhexine(4mg), Guaifenesin(50mg), Menthol(2.5mg), Terbutaline(1.25mg)
Bottle of 100ml Syrup
(Inclusive of all taxes)
Cufrid Syrup is taken with or without food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your doctor know about all other medications you are taking as some may affect, or be affected by this medicine.
Bromhexine acts on the mucus at the formative stages in the glands, within the mucus-secreting cells. Bromhexine disrupts the structure of acid mucopolysaccharide fibres in mucoid sputum and produces a less viscous mucus, which is easier to expectorate
Guaifenesin, a mucoactive drug, acts by loosening mucus in the airways and making coughs more productive. It is used for relief of wet cough and chest congestion due to the common cold, and remains the only legally marketed expectorant in the US (per OTC Monograph)
Menthol is a selective activator of transient receptor potential melastatin-8 (TRPM8) channels and is also a vasoactive compound. As a topical agent, it acts as a counter-irritant by imparting a cooling effect and by initially stimulating nociceptors and then desensitizing them.
Terbutaline is a bronchodilator, a medication that dilates (expands) air passages in the lungs. It attaches to beta adrenergic receptors on muscles surrounding the air passages, causing the muscles to relax and dilate the air passages. Wider air passages allow more air to flow in and out of the lungs.
Bromhexine hydrochloride is rapidly absorbed from the gastrointestinal tract and undergoes extensive first-pass metabolism in the liver. Its oral bioavailability is stated to be only about 20%. It is widely distributed to body tissues and is highly bound to plasma proteins.
Guaifenesin is administered orally. The plasma half-life is approximately 1 hour. Guiafenesin is rapidly hydrolyzed (60% within seven hours) and then excreted in the urine, with beta-(2-methoxyphenoxy)-lactic acid as its major urinary metabolite. No unchanged drug was detected in the urine following administration
The pharmacokinetics of terbutaline has been studied after subcutaneous adminsitration of a therapeutic dose of 250 microgram in 14 patients. Short absorption half-lives of about 7 min resulted in a fast uptake of the drug.
Menthol primarily activates the cold-sensitive TRPM8 receptors in the skin. Menthol, after topical application, causes a feeling of coolness due to stimulation of 'cold' receptors by inhibiting Ca++ currents of neuronal membranes. It may also yield analgesic properties via kappa-opioid receptor agonism.
Nausea
Indigestion
Bloating
Vomiting
Diarrhea
Stomach pain
Dizziness
Headache
Sweating
Skin rash
Hives
Tremors
Increased heart rate
Palpitations
Bromhexine is contraindicated for use in patients with known hypersensitivity or idiosyncratic reaction to bromhexine hydrochloride (or any of the other ingredients in the product).
overactive thyroid gland.
diabetes.
closed angle glaucoma.
high blood pressure.
significant uncontrolled high blood pressure.
severe disease of the arteries of the heart.
enlarged prostate.
an inability to completely empty the bladder.
glucose-6-phosphate dehydrogenase (G6PD) deficiency.
methemoglobinemia, a type of blood disorder.
abnormal heart rhythm.
decreased lung function.
seizures.
large open wound.
anemia from pyruvate kinase and G6PD deficiencies.
burns.
overactive thyroid gland.
diabetes.
a metabolic condition where the body cannot adequately use sugars called ketoacidosis.
low amount of potassium in the blood.
high blood pressure.
diminished blood flow through arteries of the heart.
a low supply of oxygen rich blood to the heart.
Cufrid Syrup may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Cufrid Syrup. Please consult your doctor.
Information regarding the use of Cufrid Syrup during breastfeeding is not available. Please consult your doctor.
Bromhexine is prescribed to loosen or thin down the mucus secretions that can plug the airways. The medication promotes the expulsion of the bronchial secretions by making it easier to clear the phlegm from the respiratory tract.
Guaifenesin is an expectorant that is indicated for providing temporary symptomatic relief from congested chests and coughs which may be due to a cold, bronchitis, and/or other breathing illnesses
This medication is used to treat minor aches and pains of the muscles/joints (such as arthritis, backache, sprains). Menthol works by causing the skin to feel cool and then warm. These feelings on the skin distract you from feeling the aches/pains deeper in your muscles and joints.
Terbutaline is indicated for prevention and reversal of bronchospasm in patients at least 12 years old, with asthma and reversible bronchospasm associated with bronchitis and emphysema.
Drug-Drug Interactions: BROMHEXINE may interact with antibiotics (e.g., erythromycin, cefalexine, ampicillin, amoxicillin, oxytetracycline), non-steroidal anti-inflammatory medicines
Guaifenesin has no known severe, serious, moderate, or mild interactions with other drugs
Menthol topical has no listed severe interactions with other drugs. Menthol topical has no listed serious interactions with other drugs. Menthol topical has no listed moderate interactions with other drugs. Menthol topical has no listed mild interactions with other drugs.
Depression drugs. When taken with terbutaline, certain drugs used to treat depression can worsen the side effects of terbutaline.
Heart drugs (beta blockers)
Blood pressure drugs (diuretics)
Measure it with a measuring cup and take it by mouth. Shake well before use. Cufrid Syrup may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
If you miss a dose of Cufrid Syrup, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines
Cufrid Syrup relieves cough associated with bronchitis, bronchial asthma, emphysema and other broncho-pulmonary disorders.
It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
If you are diabetic, monitor your blood glucose regularly while taking this medicine.
Inform your doctor if you have a history of thyroid or heart disease.
Stop taking Cufrid Syrup and inform your doctor if your cough persists for more than 1 week, tends to recur, or is accompanied by a fever, rash or persistent headache.
Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Cufrid Syrup may be taken with or without food, but it is better to take it at a fixed time.
Q. What are the instructions for the storage and disposal of Cufrid Syrup?
Keep this medicine in the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Q. Can I take Cufrid Syrup along with other medicines?
Inform your doctor about the medicines you might be taking before using Cufrid Syrup. Let your doctor know if you have any other medical condition.
Q. Will a higher than the recommended dose of Cufrid Syrup be more effective?
No, taking a higher than the recommended dose may not be more effective, rather it may increase the chances of having some serious side effects and toxicity. If you experience increased severity of your symptoms, that are not relieved by the recommended doses, please consult your doctor for re-evaluation.
