Manufacturer: Pfizer Ltd
Salt Composition : Cytarabine(1000mg)
Cytosar 1000mg Injection is given as an injection into the vein or under skin by the healthcare professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include rash, skin ulcer, nausea, vomiting, and hair loss. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections or bleeding. Inform your doctor if you notice chills, unusual bleeding or bruising and black and tarry stools. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.
Before taking it, tell your doctor if you have bleeding, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
The sugar moiety of cytarabine hinders the rotation of the molecule within the DNA. The DNA replication ceases, specifically during the S phase of the cell cycle, making it a specific drug for rapidly dividing cells, such as those seen in cancer
As cytarabine is an S-phase-specific drug, prolonged exposure of cells to cytotoxic concentrations is critical to achieve maximum cytotoxic activity. However, the activity of cytarabine is decreased by its rapid deamination to the biologically inactive metabolite uracil arabinoside.
Rash
Skin ulcer
Nausea
Vomiting
Hair loss
Abdominal pain
Anal ulcers
Anemia (low number of red blood cells)
Decreased white blood cell count
Fever
Infection
Abnormal liver function
Low blood platelets
Mouth ulcer
Pneumonia
Sepsis
Mouth sore
Stomatitis (Inflammation of the mouth)
Cytarabine is contraindicated in patients who have had a hypersensitivity reaction to it or any of the fundamental ingredients used in the preparation of the drug. With active meningeal infections, liposomal cytarabine is also contraindicated
Cytosar 1000mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Cytosar 1000mg Injection. Please consult your doctor.
Cytosar 1000mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Labeled indications of cytarabine include the treatment of acute lymphoblastic leukemia, remission induction therapy in acute myeloid leukemia in adult and pediatric patients, the treatment of chronic myeloid leukemia (blast phase), and prophylaxis and treatment of meningeal leukemia
infections.
myelosuppression.
hepatic dysfunction.
renal dysfunction.
Kindly do not self administer.
Store below 30°C
Consult a doctor before taking any medicines
Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. Is Cytosar 1000mg Injection a vesicant?
No. Cytosar 1000mg Injection is not a vesicant (irritant) but should be handled with care.
Q. Is Cytosar 1000mg Injection ototoxic?
No. Ototoxicity is not reported with use of Cytosar 1000mg Injection. However, please consult your doctor if you experience such a side effect.
Q. Is Cytosar 1000mg Injection cytotoxic?
Yes. Cytosar 1000mg Injection is a cytotoxic drug.
Q. Does Cytosar 1000mg Injection cause hair loss?
Yes. Cytosar 1000mg Injection may cause hair loss.
