Manufacturer: Alkem Laboratories Ltd
Salt Composition : Daclatasvir(60mg)
Daclakem 60mg Tablet should be taken in the dose and duration as advised by your doctor. It should be taken with or without food, preferably at a fixed time. Do not skip any doses and finish the full course of treatment even if you feel better If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Daclatasvir is a direct-acting antiviral agent that targets the NS5A and causes a decrease in serum HCV RNA levels. It disrupts HCV replication by specifically inhibiting the critical functions of an NS5A protein in the replication complex 3. It is shown to cause downregulation of the hyperphosphorylation of NS5A
Daclatasvir undergoes rapid absorption, with a time to reach maximum plasma concentration of 1-2 h and an elimination half-life of ~ 10 to 14 h observed in single-ascending dose studies. Steady state was achieved by day 4 in multiple-ascending dose studies.
Fatigue
Headache
Nausea
Insomnia (difficulty in sleeping)
Anemia (low number of red blood cells)
Do not use this medicine together with certain other medicines, including carbamazepine (Tegretol®), phenytoin (Dilantin®), rifampin (Rifadin®), or St. John's wort. Using these medicines together may cause unwanted effects. Do not use this medicine together with sofosbuvir and amiodarone
Daclakem 60mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Daclakem 60mg Tablet. Please consult your doctor.
Daclakem 60mg Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
DAKLINZA is indicated for use with sofosbuvir, with or without ribavirin, for the treatment of patients with chronic hepatitis C virus (HCV) genotype 1 or genotype 3 infection
Amiodarone may interact with sofosbuvir. Tell your doctor and pharmacist if you are taking amiodarone. Other medications can affect the removal of daclatasvir from your body, which may affect how daclatasvir works
Do not chew, crush or break it. Daclakem 60mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
If you miss a dose of Daclakem 60mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
Consult a doctor before taking any medicines
Daclakem 60mg Tablet is used along with other medications for the treatment of chronic hepatitis C virus (HCV) infection.
Do not skip any doses and finish the full course of treatment even if you feel better.
It has fewer side effects compared to other similar medications.
Take it with food, preferably at the same time everyday.
You will usually need to take this medicine every day for either 12 or 24 weeks.
It may cause fatigue, dizziness, and blurred vision. Don't drive or do anything requiring concentration until you know how it affects you.
Your doctor may monitor your liver function and the amount of hepatitis C virus in your body regularly.
Do not stop taking Daclakem 60mg Tablet without your doctor’s advice.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Daclakem 60mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
