Manufacturer: Johnson & Johnson Ltd
Salt Composition : Decitabine(50mg)
Dacogen Injection is also used with certain other medicines as part of combination chemotherapy. It is given as an injection into the vein under the supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Decitabine (5-aza-2′-deoxycytidine) is a hypomethylating agent with a dual mechanism of action: reactivation of silenced genes and differentiation at low doses, and cytotoxicity at high doses
Decitabine is in a class of medications called hypomethylation agents. It works by helping the bone marrow produce normal blood cells and by killing abnormal cells in the bone marrow.
Nausea
Vomiting
Headache
Fever
Lung infection
Decreased white blood cell count (neutrophils)
Nosebleeds
Anemia (low number of red blood cells)
Low blood platelets
Diarrhea
Pneumonia
Anemia, bone marrow suppression, infection, neutropenia, thrombocytopenia. ...
Hepatic disease. ...
Renal disease. ...
Pregnancy. ...
Contraception requirements, infertility, male-mediated teratogenicity, pregnancy testing, reproductive risk. ...
Breast-feeding.
Dacogen Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Dacogen Injection. Please consult your doctor.
Dacogen Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
DACOGEN is indicated for treatment of adult patients with myelodysplastic syndromes (MDS) including previously treated and untreated, de novo and secondary MDS of all French- American-British subtypes (refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia
Abciximab The risk or severity of bleeding can be increased when Abciximab is combined with Decitabine.
Acenocoumarol The risk or severity of bleeding can be increased when Acenocoumarol is combined with Decitabine.
Kindly do not self administer.
Store below 30°C
Consult a doctor before taking any medicines
Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. Is Dacogen Injection a vesicant?
Dacogen Injection is not a vesicant and is not known to cause severe local tissue damage upon extravasation (leaking of injected Dacogen Injection into the surrounding tissues from the site of administration) when injected.
Q. How effective is Dacogen Injection?
The effectiveness of Dacogen Injection depends upon several factors including the patient's clinical condition, number of treatment cycles etc. and may vary depending upon the individual response.
Q. Does Dacogen Injection cause hair loss?
Yes. Hair loss (alopecia) is among the known side effects of Dacogen Injection.
Q. How is Dacogen Injection administered?
Dacogen Injection comes as a powder to be to be added to fluid and injected slowly over 3 hours into a vein (slow i.v infusion) by a doctor who is experienced in giving chemotherapy medications for cancer in a hospital or a clinic.
