Darbelife 40mcg Pfs (Injection)

Manufacturer: Hetero Drugs Ltd

Salt Composition : Darbepoetin alfa(40mcg)


Darbelife 40mcg Pfs Injection is a medicine that needs to be used with utmost care because it can lead to serious side effects. It is important that you seek treatment from a doctor who is experienced in providing this medical therapy. You should follow all the directions of the doctor strictly. It is given under the supervision of a healthcare professional.



Basic Information

Mechanism Of Action

Darbepoetin alfa is in a class of medications called erythropoiesis-stimulating agents (ESAs). It works by causing the bone marrow (soft tissue inside the bones where blood is made) to make more red blood cells.

Pharmacokinets

A long terminal half-life characterizes the pharmacokinetic profile of darbepoetin alfa following both IV and SC administration. The most recent pharmacokinetic studies using sampling times of 27 or 28 days established that the mean terminal half-life of darbepoetin alfa is 70–105 h when administered SC

Side Effects

High blood pressure

Rash

Injection site pain

Breathlessness

Cough

Peripheral edema

Procedural hypotension (low blood pressure)

Convulsion

Thromboembolism


Contra Indications

inadequate folic acid.

inadequate vitamin B12.

porphyria.

anemia from inadequate iron.

high blood pressure.

significant uncontrolled high blood pressure.

a heart attack.

a clot in the lung

Pregnancy Related Information

Darbelife 40mcg Pfs Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.


Product And Alcohol Interaction

It is not known whether it is safe to consume alcohol with Darbelife 40mcg Pfs Injection. Please consult your doctor.


Breast Feeding Related Information

Darbelife 40mcg Pfs Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.


Indications

Aranesp is indicated for the treatment of anemia in patients with non-myeloid malignancies where anemia is due to the effect of concomitant myelosuppressive chemotherapy, and upon initiation, there is a minimum of two additional months of planned chemotherapy

Interactions

belzutifan.

benazepril.

C1 esterase inhibitor (human)

captopril.

carfilzomib.

conestat alfa.

cyclosporine.

enalapril.


Typical Dosage

Kindly do not self administer.


Storage Requirements

Store in a refrigerator (2 - 8°C). Do not freeze.


Effects Of Missed Dosage

If you miss a dose of Darbelife 40mcg Pfs Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.


Effects Of Overdose

Consult a doctor before taking any medicines

Expert Advice

Darbelife 40mcg Pfs Injection helps in the treatment of anemia that may have occurred due to chronic kidney disease or cancer chemotherapy.

It is given as a single injection under your skin.

Your doctor may get your blood tests done regularly to monitor the levels of hemoglobin, blood cells and electrolytes such as potassium in your blood.

Stop taking Darbelife 40mcg Pfs Injection and inform your doctor if you develop shortness of breath or skin rash.

How To Use

Your doctor or nurse will give you this medicine. Kindly do not self administer.


FAQs

Q. How long does it take for Darbelife 40mcg Pfs Injection to start working?

You will be able to notice an increase in the count of red blood cells (hemoglobin levels) in 2-6 weeks of starting Darbelife 40mcg Pfs Injection. If you have any other concerns, consult your doctor.

Q. Is Darbelife 40mcg Pfs Injection safe to use?

Darbelife 40mcg Pfs Injection is a medicine that needs to be used with utmost care because it can lead to serious side effects and even death of the patient. It is important that you seek treatment from a doctor who is experienced in providing Darbelife 40mcg Pfs Injection therapy. Follow all the directions strictly.

Q. Other than PRCA, can there be other reasons for not responding to Darbelife 40mcg Pfs Injection?

You may not respond to Darbelife 40mcg Pfs Injection if you have deficiencies of iron, folic acid or vitamin B12. It is important that you take measures to correct these deficiencies. Other reasons behind not responding to the treatment could be bleeding, infections, inflammation and bone marrow fibrosis. Therefore, consult our doctor regarding the same.

Q. Can Darbelife 40mcg Pfs Injection be used in children?

Yes, Darbelife 40mcg Pfs Injection is used to treat anemia due to chronic kidney disease in children who are above 1 year of age. The effectiveness of Darbelife 40mcg Pfs Injection and side effects seen in children are similar to adults. However, consult your doctor if you are not sure.