Manufacturer: LG Lifesciences
Salt Composition : Darbepoetin alfa(40mcg)
Darcept 40 Injection is a medicine that needs to be used with utmost care because it can lead to serious side effects. It is important that you seek treatment from a doctor who is experienced in providing this medical therapy. You should follow all the directions of the doctor strictly. It is given under the supervision of a healthcare professional.It may cause side effects like high blood pressure and hypersensitivity. Inform your doctor if there are symptoms of very high blood pressure such as severe headache, problems with your eyesight, nausea, vomiting, or fits (seizures).
Darcept 40 Injection is an erythropoiesis-stimulating agent (ESA). It works by stimulating the bone marrow (soft tissue inside the bones which produces red blood cells) to produce more red blood cells.
A long terminal half-life characterizes the pharmacokinetic profile of darbepoetin alfa following both IV and SC administration. The most recent pharmacokinetic studies using sampling times of 27 or 28 days established that the mean terminal half-life of darbepoetin alfa is 70–105 h when administered SC.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Darcept
High blood pressure
Rash
Injection site pain
Breathlessness
Cough
Peripheral edema
Procedural hypotension (low blood pressure)
Convulsion
Thromboembolism
inadequate folic acid
inadequate vitamin B12
porphyria
anemia from inadequate iron
high blood pressure
significant uncontrolled high blood pressure
a heart attack
a clot in the lung
sudden and serious symptoms of heart failure called acute decompensated heart failure
a stroke
obstruction of a blood vessel by a blood clot
a blood clot
blood clot in a deep vein of the extremities
seizures
visible water retention
a blood clot in a vascular access device
pure red cell aplasia
Darcept 40 Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Darcept 40 Injection. Please consult your doctor.
Darcept 40 Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Use with caution
Below 9years: Contraindicated
Darbepoetin alfa is indicated for the treatment of anemia due to chronic kidney disease (CKD), including patients on dialysis and patients not on dialysis.
belzutifan.
benazepril.
C1 esterase inhibitor (human)
captopril.
carfilzomib.
conestat alfa.
cyclosporine.
enalapril.
Kindly do not self administer.
Store in a refrigerator (2 - 8°C). Do not freeze.
If you miss a dose of Darcept 40 Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Darcept 40 Injection helps in the treatment of anemia that may have occurred due to chronic kidney disease or cancer chemotherapy.
It is given as a single injection under your skin.
Your doctor may get your blood tests done regularly to monitor the levels of hemoglobin, blood cells and electrolytes such as potassium in your blood.
Stop taking Darcept 40 Injection and inform your doctor if you develop shortness of breath or skin rash.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. How long does it take for Darcept 40 Injection to start working?
You will be able to notice an increase in the count of red blood cells (hemoglobin levels) in 2-6 weeks of starting Darcept 40 Injection. If you have any other concerns, consult your doctor.
Q. Is Darcept 40 Injection safe to use?
Darcept 40 Injection is a medicine that needs to be used with utmost care because it can lead to serious side effects and even death of the patient. It is important that you seek treatment from a doctor who is experienced in providing Darcept 40 Injection therapy. Follow all the directions strictly.
Q. Other than PRCA, can there be other reasons for not responding to Darcept 40 Injection?
You may not respond to Darcept 40 Injection if you have deficiencies of iron, folic acid or vitamin B12. It is important that you take measures to correct these deficiencies. Other reasons behind not responding to the treatment could be bleeding, infections, inflammation and bone marrow fibrosis. Therefore, consult our doctor regarding the same.
Q. Can Darcept 40 Injection be used in children?
Yes, Darcept 40 Injection is used to treat anemia due to chronic kidney disease in children who are above 1 year of age. The effectiveness of Darcept 40 Injection and side effects seen in children are similar to adults. However, consult your doctor if you are not sure.
Q. Can Darcept 40 Injection affect blood pressure?
Yes, Darcept 40 Injection can affect blood pressure. During initial therapy with Darcept 40 Injection, blood pressure should be monitored and those who have high blood pressure should take appropriate measures to control blood pressure. Your doctor may stop Darcept 40 Injection if the blood pressure remains uncontrolled.
