Manufacturer: Sun Pharmaceutical Industries Ltd
Salt Composition : Deferasirox(500mg)
Defrijet 500 Tablet should be taken on an empty stomach. Take it in the exact dose and duration and take it regularly at a fixed time each day to get the maximum benefit from it.
Using of Defrijet 500 Tablet may cause common side effects such as nausea, headache, constipation, diarrhea, and increased liver enzyme. If the side effects persist or worsen, inform your doctor.
Before using this medicine, let your doctor know if you have any kidney or liver diseases. Let your doctor also know about all the other medicines you are taking to ensure your safety.
Deferasirox works in treating iron toxicity by binding trivalent (ferric) iron (for which it has a strong affinity), forming a stable complex which is eliminated via the kidneys. The absolute bioavailability (AUC) of deferasirox tablets for oral suspension is 70% compared to an intravenous dose
At the end of the 45-minute IV infusion, deferasirox plasma concentra- tions reached a maximum (Cmax) of 16.4 ± 2.4 µmol/L (arithmetic mean ± standard deviation) and declined rapidly thereafter with a mean elimination half-life (t1/2) of 4.49 ± 0.70 hours.
Nausea
Headache
Vomiting
Rash
Abdominal pain
Constipation
Itching
Increased liver enzymes
Abdominal distension
Diarrhea
cancer or malignancy.
dehydration.
anemia.
a significant decrease in certain blood clotting cells called platelets.
low levels of a type of white blood cell called neutrophils.
increased pressure in the eye.
clouding of the lens of the eye called cataracts.
hearing loss.
Defrijet 500 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Defrijet 500 Tablet. Please consult your doctor.
Defrijet 500 Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Exjade (deferasirox) is indicated for the treatment of chronic iron overload due to blood transfusions (transfusional hemosiderosis) in patients 2 years of age and older. In these patients, Exjade has been shown to reduce liver iron concentration and serum ferritin levels.
Some products that may interact with this drug include: other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, NSAIDs such as ibuprofen/naproxen, "blood thinners" such as dabigatran/warfarin). Aspirin can increase the risk of bleeding when used with this medication
Do not chew, crush or break it. Defrijet 500 Tablet is to be taken empty stomach.
Store below 30°C
If you miss a dose of Defrijet 500 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines
Defrijet 500 Tablet is used to reduce excess iron from the body.
Inform your doctor if you also have upper stomach pain, clay-colored stools, or jaundice (yellowing of your skin or the whites of your eyes).
Take an adequate amount of water while taking Defrijet 500 Tablet.
Defrijet 500 Tablet may cause dizziness. It is advisable not to drive or operate any machinery until you feel normal again.
If you are taking any antacid, take them 2 hours before or after Defrijet 500 Tablet.
Inform your doctor if you have any liver or kidney disease.
Inform your doctor if you are pregnant or breastfeeding.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Defrijet 500 Tablet is to be taken empty stomach.
Q. What is Defrijet 500 Tablet used for?
Defrijet 500 Tablet is used for removing excess iron from the body due to repeated blood transfusions in patients with beta thalassemia major (a blood disorder)
Q. How does Defrijet 500 Tablet work?
Defrijet 500 Tablet works by binding to excess iron in the blood and removing it from the body through stool.
