Manufacturer: RKG Pharma
Salt Composition : Amitriptyline(25mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Depline Forte 25 mg/10 mg Tablet is taken with or without food. However, it is advised to take it at a fixed time each day to maintain a consistent level of medicine in the blood. In case you miss a dose of this medicine, take it as soon as you remember. Never skip any dose and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to the doctor as it may worsen your symptoms. Taking this medicine for a long time may require regular monitoring of blood and liver functions.
Some common side effects of this medicine include constipation, difficulty in urination, weight gain, confusion, orthostatic hypotension (sudden lowering of blood pressure on standing). This medicine may cause weight loss. In case of losing weight, consult a dietitian for dietary supplements or try to increase your food portion. Most of the common side effects tend to be mild. Your doctor may be able to suggest ways of preventing or reducing side effects if they bother you or do not go away. Serious side effects are rare. Remember to inform your doctor if you develop any unusual changes in mood as it may lead to suicidal thoughts.
Take caution while taking medicine if you are suffering from liver disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Amitriptyline increases noradrenergic or serotonergic neurotransmission by blocking the norepinephrine or serotonin transporter (NET or SERT) at presynaptic terminals
Amitriptyline undergoes extensive hepatic presystemic elimination, and its systemic bioavailability ranges from 33% to 62% after oral administration [2]. A highly lipophilic compound, amitriptyline is widely distributed throughout the body and extensively bound to tissue and plasma proteins
Constipation
Difficulty in urination
Weight gain
Confusion
Orthostatic hypotension (sudden lowering of blood pressure on standing)
Tiredness
Blurred vision
Dryness in mouth
Increased heart rate
Uncoordinated body movements
Depression
Memory impairment
overactive thyroid gland.
manic-depression.
suicidal thoughts.
alcoholism.
wide-angle glaucoma.
closed angle glaucoma.
heart attack within the last 30 days.
torsades de pointes, a type of abnormal heart rhythm
Depline Forte 25 mg/10 mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is unsafe to consume alcohol with Depline Forte 25 mg/10 mg Tablet.
Depline Forte 25 mg/10 mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
The Non-FDA approved indications are anxiety, post-traumatic stress disorder, insomnia, chronic pain (diabetic neuropathy, fibromyalgia), irritable bowel syndrome, interstitial cystitis (bladder pain syndrome), migraine prophylaxis, postherpetic neuralgia, and sialorrhea
Some products that may interact with this drug include: arbutamine, disulfiram, thyroid supplements, other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, NSAIDs such as ibuprofen, "blood thinners" such as warfarin), anticholinergic drugs (such as belladonna alkaloids), certain
Do not chew, crush or break it. Depline Forte 25 mg/10 mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
If you miss a dose of Depline Forte 25 mg/10 mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines
Depline Forte 25 mg/10 mg Tablet is prescribed for the treatment of depression.
It can take a week or two after starting this treatment before the effect begins to build up, and 4-6 weeks before you feel the full benefit. Do not stop taking it after a week or two, feeling it is not helping.
Do not stop taking Depline Forte 25 mg/10 mg Tablet unless your doctor tells you to do so. Stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually when this becomes necessary.
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
Inform your doctor if you are taking any other antidepressants.
Inform your doctor immediately if you get thoughts about harming yourself or ending your life.
Avoid alcohol while taking Depline Forte 25 mg/10 mg Tablet.
If you have diabetes, you will be asked to monitor your blood glucose level regularly as Depline Forte 25 mg/10 mg Tablet may affect the levels of sugar in your blood.
Depline Forte 25 mg/10 mg Tablet is prescribed for the treatment of depression.
It can take a week or two after starting this treatment before the effect begins to build up, and 4-6 weeks before you feel the full benefit. Do not stop taking it after a week or two, feeling it is not helping.
Do not stop taking Depline Forte 25 mg/10 mg Tablet unless your doctor tells you to do so. Stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually when this becomes necessary.
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
Inform your doctor if you are taking any other antidepressants.
Inform your doctor immediately if you get thoughts about harming yourself or ending your life.
Avoid alcohol while taking Depline Forte 25 mg/10 mg Tablet.
If you have diabetes, you will be asked to monitor your blood glucose level regularly as Depline Forte 25 mg/10 mg Tablet may affect the levels of sugar in your blood.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Depline Forte 25 mg/10 mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Q. Are there any important warnings associated with use of Depline Forte 25 mg/10 mg Tablet?
During the first few months of treatment, Depline Forte 25 mg/10 mg Tablet may increase suicidal thoughts or actions in some patients. Patients having mood or behavioral disorder have a high risk of developing suicidal thoughts and actions. You should pay close attention and report your doctor of any such behavior or mood changes. Make sure that you visit the doctor for the scheduled follow-up appointments.
Q. Can I stop taking Depline Forte 25 mg/10 mg Tablet when my symptoms are relieved?
No, you should continue to take Depline Forte 25 mg/10 mg Tablet, even if you feel well. If you stop Depline Forte 25 mg/10 mg Tablet suddenly, serious withdrawal symptoms may occur. Consult your doctor if the symptoms are relieved, he might decrease your dose gradually.
Q. How to manage weight gain associated with the use of Depline Forte 25 mg/10 mg Tablet?
There are reports which suggest that the use of Depline Forte 25 mg/10 mg Tablet can cause weight gain. If you maintain good eating habits and exercise regularly, you might not gain any weight. An important to remember is that it is easier to prevent weight gain than losing increased weight.
Q. What are the instructions for storage and disposal of Depline Forte 25 mg/10 mg Tablet?
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
