Manufacturer: RKG Pharma
Salt Composition : Amitriptyline(12.5mg), Chlordiazepoxide(5mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Depline Plus 12.5 mg/5 mg Tablet is taken with or without food. However, it is advised to take it at a fixed time each day to maintain a consistent level of medicine in the blood. In case you miss a dose of this medicine, take it as soon as you remember. Never skip any dose and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to the doctor as it may worsen your symptoms. Taking this medicine for a long time may require regular monitoring of blood and liver functions.
Depline Plus 12.5 mg/5 mg Tablet is a combination of two medicines: Amitriptyline and Chlordiazepoxide, which treats depression. Amitriptyline is a tricyclic antidepressant which increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression.
Amitriptyline undergoes extensive hepatic presystemic elimination, and its systemic bioavailability ranges from 33% to 62% after oral administration [2]. A highly lipophilic compound, amitriptyline is widely distributed throughout the body and extensively bound to tissue and plasma proteins.Chlordiazepoxide is a long-acting benzodiazepine drug. The half-life of Chlordiazepoxide is 5 – 30 hours but has an active benzodiazepine metabolite (desmethyldiazepam), which has a half-life of 36 – 200 hours.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Depline Plus
Constipation
Difficulty in urination
Weight gain
Confusion
Orthostatic hypotension (sudden lowering of blood pressure on standing)
Tiredness
Blurred vision
Dryness in mouth
Increased heart rate
Uncoordinated body movements
Depression
Memory impairment
If you are suffering from any of the following diseases, you should not take Amitriptyline + Chlordiazepoxide unless your doctor advises you to do so -
Suicidal Tendency
Kidney Disease
Liver Disease
Heart Disease
Depline Plus 12.5 mg/5 mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is unsafe to consume alcohol with Depline Plus 12.5 mg/5 mg Tablet.
Depline Plus 12.5 mg/5 mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Use with caution
Below 9years: Contraindicated
This product contains 2 medicines (amitriptyline, chlordiazepoxide) and is used to treat mental/mood disorders such as depression with symptoms of anxiety. Amitriptyline belongs to a class of medications called tricyclic antidepressants.
AMITRIPTYLINE+CHLORDIAZEPOXIDE may have interaction with an anti-depressant (duloxetine, venlafaxine), anti-convulsant (gabapentin, pregabalin, topiramate), anti-thyroid (levothyroxine), and anti-anxiety (alprazolam), corticosteroid (fluticasone), beta-agonist (salmeterol), anti-anxiety (lorazepam), opioid analgesic (morphine) and diuretic (furosemide).
Do not chew, crush or break it. Depline Plus 12.5 mg/5 mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
If you miss a dose of Depline Plus 12.5 mg/5 mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Depline Plus 12.5 mg/5 mg Tablet is prescribed for the treatment of depression.
It can take a week or two after starting this treatment before the effect begins to build up, and 4-6 weeks before you feel the full benefit. Do not stop taking it after a week or two, feeling it is not helping.
Do not stop taking Depline Plus 12.5 mg/5 mg Tablet unless your doctor tells you to do so. Stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually when this becomes necessary.
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
Inform your doctor if you are taking any other antidepressants.
Inform your doctor immediately if you get thoughts about harming yourself or ending your life.
Avoid alcohol while taking Depline Plus 12.5 mg/5 mg Tablet.
If you have diabetes, you will be asked to monitor your blood glucose level regularly as Depline Plus 12.5 mg/5 mg Tablet may affect the levels of sugar in your blood.
Depline Plus 12.5 mg/5 mg Tablet is prescribed for the treatment of depression.
It can take a week or two after starting this treatment before the effect begins to build up, and 4-6 weeks before you feel the full benefit. Do not stop taking it after a week or two, feeling it is not helping.
Do not stop taking Depline Plus 12.5 mg/5 mg Tablet unless your doctor tells you to do so. Stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually when this becomes necessary.
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
Inform your doctor if you are taking any other antidepressants.
Inform your doctor immediately if you get thoughts about harming yourself or ending your life.
Avoid alcohol while taking Depline Plus 12.5 mg/5 mg Tablet.
If you have diabetes, you will be asked to monitor your blood glucose level regularly as Depline Plus 12.5 mg/5 mg Tablet may affect the levels of sugar in your blood.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Depline Plus 12.5 mg/5 mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Q. Are there any important warnings associated with use of Depline Plus 12.5 mg/5 mg Tablet?
During the first few months of treatment, Depline Plus 12.5 mg/5 mg Tablet may increase suicidal thoughts or actions in some patients. Patients having mood or behavioral disorder have a high risk of developing suicidal thoughts and actions. You should pay close attention and report your doctor of any such behavior or mood changes. Make sure that you visit the doctor for the scheduled follow-up appointments.
Q. Can I stop taking Depline Plus 12.5 mg/5 mg Tablet when my symptoms are relieved?
No, you should continue to take Depline Plus 12.5 mg/5 mg Tablet, even if you feel well. If you stop Depline Plus 12.5 mg/5 mg Tablet suddenly, serious withdrawal symptoms may occur. Consult your doctor if the symptoms are relieved, he might decrease your dose gradually.
Q. How to manage weight gain associated with the use of Depline Plus 12.5 mg/5 mg Tablet?
There are reports which suggest that the use of Depline Plus 12.5 mg/5 mg Tablet can cause weight gain. If you maintain good eating habits and exercise regularly, you might not gain any weight. An important to remember is that it is easier to prevent weight gain than losing increased weight.
Q. What are the instructions for storage and disposal of Depline Plus 12.5 mg/5 mg Tablet?
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Q. Can the use of Depline Plus 12.5 mg/5 mg Tablet cause sleepiness?
Yes, Depline Plus 12.5 mg/5 mg Tablet can make you feel sleepy. Avoid driving, operating machinery, working at heights or participating in potentially dangerous activities till you know how this medicine affects you.
Q. Can the use of Depline Plus 12.5 mg/5 mg Tablet affect my sexual life?
The use of Depline Plus 12.5 mg/5 mg Tablet can affect the sexual life of both men and women. Most commonly caused problems are decreased sexual desire, erectile dysfunction (inability to develop or maintain erection during the sexual activity) and inability to reach orgasm. It can also cause a decrease in satisfaction and cause discomfort while having sex. If you experience these problems, discuss with your doctor.
Q. Can I drink alcohol while taking Depline Plus 12.5 mg/5 mg Tablet?
No, do not drink alcohol while you are taking Depline Plus 12.5 mg/5 mg Tablet. Drinking alcohol can increase the severity of drowsiness or sleepiness caused by Depline Plus 12.5 mg/5 mg Tablet.
Q. Can the use of Depline Plus 12.5 mg/5 mg Tablet change the color of urine?
Yes, Depline Plus 12.5 mg/5 mg Tablet can the change the color of the urine to blue or green. This change of color is expected while using Depline Plus 12.5 mg/5 mg Tablet, and it is not harmful. Your urine color becomes normal once you stop taking Depline Plus 12.5 mg/5 mg Tablet.
Q. How long does Depline Plus 12.5 mg/5 mg Tablet take to work?
Everybody responds differently to the treatment. In general, it can take several weeks to feel the full benefits of Depline Plus 12.5 mg/5 mg Tablet, although some people will start to feel better sooner. When taking Depline Plus 12.5 mg/5 mg Tablet, it is important to give it time to work.
