Manufacturer: Coxswain Healthcare
Salt Composition : Clobetasol, Miconazole, Neomycin
Tube of 15gm Cream
(Inclusive of all taxes)
Dermibet N Cream is only meant for external use and should be used as advised by your doctor. A thin layer of the medicine should be applied only to the affected areas of the skin with clean and dry hands. If it gets into your eyes, nose, mouth, or vagina rinse with water. It may take several days to weeks for your symptoms to improve, but you should keep using this medicine regularly. The course of the treatment should be completed to ensure better efficacy of the medicine. If your condition does not improve or gets worse, you should talk to your doctor.
Clobetasol propionate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. This results in synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators.
Miconazole inhibits the synthesis of ergosterol, a major component of fungal cell membranes. This interferes with the barrier function of the membrane and with membrane-bound enzymes
Neomycin is bactericidal in action. Similar to other aminoglycosides, it inhibits bacterial protein synthesis through irreversible binding to the 30 S ribosomal subunit of susceptible bacteria.
Some researchers have found that suppression of cortisol levels is still apparent 96 hours after topical use of this medicine, which implies that clobetasol can stay in your system for long periods of time, possibly for up to a few weeks. Clobetasol is not recommended to be used for more than two consecutive weeks
The salivary pharmacokinetic profile of miconazole in the oral gel showed peak concentrations 30 min after each gel application. The mean maximum salivary miconazole concentration over the 12-h period occurred 30 min after the second application of the gel.
There is limited information on the metabolism of neomycin, as there is limited systemic absorption following drug administration. Metabolism is deemed to be negligible. The small absorbed fraction of neomycin is excreted by the kidney. The unabsorbed portion of the drug is excreted unchanged in the feces.
Application site reactions (burning, irritation, itching and redness)
Thinning of skin
Clobetasol+Miconazole+Neomycin is considered to be harmful for patients with known allergy to any of the components or excipients of this medicine. Its use should be avoided in case of any primary infected skin lesions caused by infection with fungi, bacteria or yeast, viral infections
Dermibet N Cream may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
No interaction found/established
Dermibet N Cream is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.
Store below 30°C
If you miss a dose of Dermibet N Cream, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Dermibet N Cream must be applied as a thin layer on the affected area as prescribed by your doctor.
Do not use this medicine more often or for longer than advised by your doctor.
Before each application, wash the affected area with soap and water and dry well.
Avoid getting it in the eyes, mouth or nose. Rinse with cold water if you accidentally get it in these areas.
Do not cover the area being treated with airtight dressings such as bandages unless directed by a doctor, as this may increase the risk of side effects.
Inform your doctor if the treated skin area does not improve after 2-4 weeks of treatment.
This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.
Q. Can I stop using Dermibet N Cream when my symptoms are relieved?
No, do not stop using Dermibet N Cream without consulting your doctor. Use Dermibet N Cream in the dose and duration prescribed by the doctor. Usually, your condition will improve within a few days. If the condition worsens or does not improve within seven days, treatment and diagnosis should be re-evaluated. However, if the treatment is recommended to be continued for a longer duration, it should be done under medical supervision.
Q. What precautions should I take while using Dermibet N Cream?
Dermibet N Cream should be used carefully only over the affected area, avoiding the medicine from getting into the eyes. Do not apply a bandage or dressing on the area being treated, as this will increase the absorption of the medicine and increase the risk of side effects. This medicine should only be used for the condition it is prescribed for. Do not use it for any other condition without consulting your doctor. Do not give it to other people even if their condition appears to be the same.
Q. How to use Dermibet N Cream?
Dermibet N Cream should be used as advised by the doctor or as per the instructions on the label of the medicine. Apply a thin layer of it to cover the affected areas. The dose would depend on the condition for which it is prescribed. Wash your hands after using Dermibet N Cream unless it is used for treating infection of the hands. Avoid contact with the eyes.
Q. What would happen if I use a higher than the recommended dose of Dermibet N Cream for long periods?
Dermibet N Cream should be used only for the dose and duration as advised by the doctor. This medicine contains a steroid, clobetasol which when used in higher doses and for longer periods can get absorbed in the blood and cause adrenal suppression and Cushing's syndrome. It can cause weight gain, high blood pressure and rounding of the face. Its application can cause a change in color of skin at the site of application. Veins beneath the skin become visible due to the thinning and weakening of the skin. There could be an increased hair growth. If you experience an increased severity of your symptoms, please consult your doctor for re-evaluation.
Q. What are the contraindications associated with the use of Dermibet N Cream?
Use of Dermibet N Cream is considered to be harmful for patients with known allergy to any of the components or excipients of this medicine. Its use should be avoided in case of any primary infected skin lesions caused by infection with fungi, bacteria or yeast, viral infections (herpes or chickenpox). Its use should also be avoided in treating acne or rosacea. Consult your doctor before using it for any condition.
Q. What are the instructions for the storage of Dermibet N Cream?
Dermibet N Cream should be stored at or below room temperature, away from direct heat or sunlight. Do not freeze. Also, keep it away from the reach of pets and children.
