Manufacturer: Cipla Ltd
Salt Composition : Glibenclamide(2.5mg), Metformin(400mg)
Diaforte 2.5 mg/400 mg Tablet should be taken with food. Take it regularly at the same time each day to get the most benefit. Your doctor will decide what dose is best for you and this may change from time to time according to how it is working according to your blood sugar levels.
Keep taking this medicine, even if you feel well or your blood sugar levels are controlled. If you stop it without consulting your doctor, your blood sugar levels could rise and put you at risk of kidney damage, blindness, nerve problems and loss of limbs. Remember that it is only part of a treatment program that should also include a healthy diet, regular exercise, and weight reduction as advised by your doctor. Your lifestyle plays a big part in controlling diabetes.
The most common side effect of Diaforte 2.5 mg/400 mg Tablet is low blood glucose levels (hypoglycemia). Make sure you recognize the signs of having low blood glucose levels, such as sweating, dizziness, headache, and shaking and know how to deal with it. To prevent this, it's important to have regular meals and always carry a fast-acting source of glucose such as sugary food or fruit juice with you. Drinking alcohol can also increase your risk of low blood sugar levels and should be avoided. Other side effects that may be seen on taking this medicine include taste changes, nausea, diarrhea, stomach pain, headache, and upper respiratory tract infection. Some people may find that they put on weight with this medicine.
You should not take it if you have type 1 diabetes mellitus, if you have diabetic ketoacidosis (high levels of acid in your blood), or if you have severe kidney or liver disease. Before taking this medicine, tell your doctor if you have ever had heart disease. It may not be suitable. Pregnant or breastfeeding women should also consult their doctor before taking it. Your blood sugar levels should be checked regularly and your doctor may also advise blood tests to monitor your blood cell counts and liver function.
Diaforte 2.5 mg/400 mg Tablet belongs to a category of medicines known as anti-diabetic drugs. It is a combination of two medicines used to treat type 2 diabetes mellitus in adults. It helps control blood sugar levels in people with diabetes.
Metformin is rapidly distributed following absorption and does not bind to plasma proteins. No metabolites or conjugates of metformin have been identified. The absence of liver metabolism clearly differentiates the pharmacokinetics of metformin from that of other biguanides, such as phenformin.Background: Glibenclamide (Gb) may provoke long-lasting hypoglycaemic reactions, and one of the known risk factors is impaired renal function. We have demonstrated Gb to have a terminal elimination half-life of 15 h, and the main metabolites have a hypoglycaemic effect.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Diaforte
Nausea
Vomiting
Diarrhea
Flatulence
Hypersensitivity to Diaforte Tablet is a contraindication. In addition, Diaforte Tablet should not be used if you have the following conditions:
Acute myocardial infarction
Cardiovascular collapse
Concomitant administration of bosentan
Diabetic ketoacidosis
Hypersensitivity
Hypersensitivity to this drug
Renal disease
Septicemia
Diaforte 2.5 mg/400 mg Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
It is unsafe to consume alcohol with Diaforte 2.5 mg/400 mg Tablet.
Diaforte 2.5 mg/400 mg Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
Metformin also has several non-FDA-approved indications, including gestational diabetes, management of antipsychotic-induced weight gain, type 2 diabetes prevention, and the treatment and prevention of polycystic ovary syndrome (PCOS). Currently, metformin is the only ADA-recommended antidiabetic for pre-diabetes.Glibenclamide is an oral hypoglycemic (glucose lowering) drug used to control blood sugar levels in patients with type 2 diabetes in addition to diet and exercise. It belongs to the chemical group of sulfonylureas.
If you use other drugs or over the counter products at the same time, the effects of Diaforte Tablet may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Diaforte Tablet may interact with the following drugs and products:
Anti-diabetic drugs
Beta adrenergic blocking agents
Bosentan
Calcium channel blocking drugs
Chloramphenicol
Ciprofloxacin
Corticosteroids
Coumarins
Diuretics
Estrogens
Do not chew, crush or break it. Diaforte 2.5 mg/400 mg Tablet is to be taken with food.
Store below 30°C
If you miss a dose of Diaforte 2.5 mg/400 mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Diaforte 2.5 mg/400 mg Tablet.
Take it with food to lower your chance of having an upset stomach.
It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic.
Tell your doctor immediately if you experience any deep or rapid breathing or if you have persistent nausea, vomiting, and stomach pain as Diaforte 2.5 mg/400 mg Tablet may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Diaforte 2.5 mg/400 mg Tablet is to be taken with food.
Q. What is Diaforte 2.5 mg/400 mg Tablet?
Diaforte 2.5 mg/400 mg Tablet is a combination of two medicines: Glibenclamide and Metformin. This medicine is used in the treatment of type 2 diabetes mellitus (DM). It improves the blood glucose levels in adults when taken along with proper diet and regular exercise. Glibenclamide lowers the blood glucose levels by increasing the release of insulin from the pancreas. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. This combination is not indicated for the treatment of Type 1 DM.
Q. What is type 2 diabetes?
Type 2 diabetes is the most common form of diabetes. It is a condition in which the body is unable to make enough insulin, and the insulin produced by the body does not work well. When this happens, the glucose level in the blood rises and leads to serious medical problems. Symptoms of high blood sugar include frequent urination, increased thirst and increased hunger. Diabetes, if not treated properly, can cause long-term complications like neuropathy (nerve damage), nephropathy (kidney damage), eye damage (retinopathy), foot problems and also a higher risk of developing heart diseases.
Q. What are the possible side effects of Diaforte 2.5 mg/400 mg Tablet?
The use of Diaforte 2.5 mg/400 mg Tablet is associated with common side effects like hypoglycemia (low blood sugar level), altered taste, nausea, stomach pain, diarrhea, headache and upper respiratory tract infection. Its use can also lead to serious but rare side effects like lactic acidosis. On long-term use, it can also lead to vitamin B12 deficiency.
Q. Can the use of Diaforte 2.5 mg/400 mg Tablet cause hypoglycemia?
Yes, the use of Diaforte 2.5 mg/400 mg Tablet can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate and feeling anxious or shaky. It happens more often if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with this medicine. So, regular monitoring of blood sugar level is important. Always keep a quick source of sugar like glucose tablets, honey or fruit juice with you.
