Manufacturer: Abbott
Salt Composition : Chlorzoxazone(250mg), Diclofenac(50mg), Paracetamol(325mg)
Tube of 30gm Gel
(Inclusive of all taxes)
Dicloflam Forte Gel is only meant for external use and should be used strictly as advised by your doctor. Rub a thin layer of the medicine into the affected areas with clean and dry hands. Avoid getting in contact with your eyes, nose, or mouth, and avoid applying it on wounded or damaged skin. In case of accidental contact with these areas, you should rinse them with plenty of cold water.
Chlorzoxazone is a muscle relaxant. It acts by blocking nerve impulses or pain sensations that are sent to brain. Typically, it is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.
As with all NSAIDs, diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency
Paracetamol has a central analgesic effect that is mediated through activation of descending serotonergic pathways. Debate exists about its primary site of action, which may be inhibition of prostaglandin (PG) synthesis or through an active metabolite influencing cannabinoid receptors
Analysis of plasma samples indicated a rapid absorption and rapid elimination of chlorzoxazone. Average values of the elimination half-life and plasma clearance were 1.12 +/- 0.48 hr and 148.0 +/- 39.9 ml/min, respectively.
Diclofenac binds extensively to plasma albumin. The area under the plasma concentration-time curve (AUC) of diclofenac is proportional to the dose for oral doses between 25 to 150 mg. Substantial concentrations of drug are attained in synovial fluid, which is the proposed site of action for NSAIDs
It distributes rapidly and evenly throughout most tissues and fluids and has a volume of distribution of approximately 0.9L/kg. 10 to 20% of the drug is bound to red blood cells. Paracetamol is extensively metabolised (predominantly in the liver), the major metabolites being the sulphate and glucuronide conjugates.
Application site reactions (burning, irritation, itching and redness)
Nausea
Vomiting
Heartburn
Stomach pain
Diarrhea
Loss of appetite
Dryness in mouth
Chlorzoxazone is contraindicated in any patient with a known or suspected intolerance or hypersensitivity to the drug or any of the product ingredients. If a sensitivity reaction such as urticaria, pruritus, or skin erythema occurs, discontinue chlorzoxazone. Angioedema or anaphylactic reactions are extremely rare.meningitis not due to an infection.
systemic mastocytosis.
dehydration.
hepatic porphyria.
anemia.
increased risk of bleeding due to clotting disorder.
an increased risk of bleeding.
alcoholism.
caloric undernutrition.
acute liver failure.
liver problems.
a condition where the body is unable to maintain adequate blood flow called shock.
acetaminophen overdose.
acute inflammation of the liver due to hepatitis C virus.
Information regarding the use of Dicloflam Forte Gel during pregnancy is not available. Please consult your doctor.
No interaction found/established
Information regarding the use of Dicloflam Forte Gel during breastfeeding is not available. Please consult your doctor.
Chlorzoxazone is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties.
Diclofenac is indicated for treatment of primary dysmenorrhea, for relief of mild to moderate pain, for relief of the signs and symptoms of osteoarthritis, for relief of the signs and symptoms of rheumatoid arthritis, for relief of symptoms of ankylosing spondylitis and for relief of acute migraine symptoms.
Acetaminophen or paracetamol helps to reduce fever and to relieve a headache with mild to moderate pain. It is also used with other pain medications to treat low back pain, osteoarthritis, cold, and toothache
Buprenorphine Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Bupropion The metabolism of Chlorzoxazone can be decreased when combined with Bupropion
asthma.
fluid retention.
GI toxicity.
rash.
renal toxicities.
thrombosis.
porphyria.
anemia.
Despite its frequent coadministration with other drugs and widespread use, very few clinically significant drug interactions have been documented with paracetamol. Drugs that alter gastric emptying can alter paracetamol pharmacokinetics, but this does not result in toxicity in therapeutic use.
Clean and dry the affected area and apply the gel. Wash your hands after applying, unless hands are the affected area.
Store below 30°C
If you miss a dose of Dicloflam Forte Gel, skip it and continue with your normal schedule. Do not double the dose.
Consult a doctor before taking any medicines.
You have been prescribed Dicloflam Forte Gel to relieve pain due to muscle spasm.
This medicine is most effective when taken along with proper rest and physical therapy.
Avoid consuming alcohol when taking Dicloflam Forte Gel as it may cause excessive drowsiness and increase the risk of liver damage.
Older adults may have increased drowsiness, confusion, and higher risk of falling as a result of taking Dicloflam Forte Gel.
Do not take it with any other medicine containing acetaminophen (drugs for pain/fever or cough-and-cold) without asking your doctor first.
This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the gel. Wash your hands after applying, unless hands are the affected area.
