Manufacturer: Glenmark Pharmaceuticals Ltd
Salt Composition : Diclofenac(50mg), Paracetamol(500mg)
Diclot Plus 50 mg/500 mg Tablet should be taken with food. This will prevent you from getting an upset stomach. You should take it regularly as advised by your doctor. Do not take more or use it for a longer duration than recommended by your doctor.
There is considerable evidence that the antipyretic effect of paracetamol is centrally by inhibiting of prostaglandin E synthesis within the hypothalamus. However, the analgesic effect of diclofenac is peripherally by blocking impulse generation within the bradykinin sensitive chemoreceptors
Diclofenac is mainly eliminated via metabolism. Of the total dose, 60-70% is eliminated in the urine and 30% is eliminated in the feces. No significant enterohepatic recycling occurs. The terminal half-life of diclofenac is approximately 2 h, however the apparent half-life including all metabolites is 25.8-33 h.
It distributes rapidly and evenly throughout most tissues and fluids and has a volume of distribution of approximately 0.9L/kg. 10 to 20% of the drug is bound to red blood cells. Paracetamol is extensively metabolised (predominantly in the liver), the major metabolites being the sulphate and glucuronide conjugates.
Nausea
Vomiting
Stomach pain/epigastric pain
Heartburn
Diarrhea
Loss of appetite
Diclot Plus 50 mg/500 mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is unsafe to consume alcohol with Diclot Plus 50 mg/500 mg Tablet.
Diclot Plus 50 mg/500 mg Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Diclofenac+Paracetamol is used for pain relief. It relieves pain in conditions like headache, mild migraine, muscle pain, dental pain, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, or painful menses.
It's safe to take diclofenac with paracetamol or codeine. Do not take diclofenac with similar painkillers, like aspirin, ibuprofen or naproxen, without talking to a doctor. Diclofenac, aspirin, ibuprofen and naproxen all belong to the same group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs).
Do not chew, crush or break it. Diclot Plus 50 mg/500 mg Tablet is to be taken with food.
Store below 30°C
If you miss a dose of Diclot Plus 50 mg/500 mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines
You have been prescribed this combination medicine for relieving pain and inflammation.
Take it with food to avoid getting an upset stomach.
It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
Avoid consuming alcohol when taking Diclot Plus 50 mg/500 mg Tablet as it may cause excessive drowsiness and increase the risk of liver damage.
Do not take it with any other medicine containing acetaminophen (drugs for pain/fever or cough-and-cold) without asking your doctor first.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Diclot Plus 50 mg/500 mg Tablet is to be taken with food.
Q. What is Diclot Plus 50 mg/500 mg Tablet?
Diclot Plus 50 mg/500 mg Tablet is a combination of two medicines: Diclofenac and Paracetamol. This medication helps in relieving pain and inflammation. It works by lowering the levels of chemical substances in the body that cause pain and inflammation. Paracetamol / Acetaminophen has an early onset of action which means that it takes very less time to start its action and it helps in relieving the symptoms till diclofenac starts working.
Q. Is it safe to use Diclot Plus 50 mg/500 mg Tablet?
Yes, Diclot Plus 50 mg/500 mg Tablet is safe for most of the patients. However, in some patients it may cause some unwanted common side effects like nausea, vomiting, stomach pain, heartburn, diarrhea and other uncommon and rare side effects. Inform your doctor if you experience any persistent problem while taking this medication.
Q. Can I stop taking Diclot Plus 50 mg/500 mg Tablet when my pain is relieved?
Diclot Plus 50 mg/500 mg Tablet, when used for long-term pain relief, should be continued for as long as advised by your physician. It can be discontinued if you are using it for short-term pain relief.
Q. Can the use of Diclot Plus 50 mg/500 mg Tablet cause nausea and vomiting?
Yes, the use of Diclot Plus 50 mg/500 mg Tablet can cause nausea and vomiting. Taking it with milk, food or with antacids can prevent nausea. Avoid taking fatty or fried foods along with this medication. In case of vomiting, drink plenty of water or other fluids by taking small frequent sips. Talk to your doctor if vomiting persists and you notice signs of dehydration, like dark colored and strong-smelling urine and a low frequency of urination. Do not take any other medicine without speaking to your doctor.
Q. Can the use of Diclot Plus 50 mg/500 mg Tablet cause dizziness?
Yes, the use of Diclot Plus 50 mg/500 mg Tablet can cause dizziness (feeling faint, weak, unsteady or lightheaded) in some patients. If you feel dizzy or lightheaded it is better to rest for some time and resume once you feel better.
Q. Can the use of Diclot Plus 50 mg/500 mg Tablet cause damage to kidneys?
Yes, the long-term use of Diclot Plus 50 mg/500 mg Tablet can cause damage to the kidneys. Normal kidneys produce a chemical called prostaglandins that protect them from damage. Use of painkillers lowers the levels of prostaglandins in the body leading to kidney damage on long-term use. Use of painkillers is not recommended in patients with underlying kidney disease.
Q. Are there any specific contraindications associated with the use of Diclot Plus 50 mg/500 mg Tablet?
The use of Diclot Plus 50 mg/500 mg Tablet is considered to be harmful in patients with known allergy to painkillers (NSAIDs) or any of the components or excipients of this medicine. The use of this medicine should preferably be avoided in patients with a history of stomach ulcers or in patients with active, recurrent stomach ulcer/bleeding. It should also be avoided in patients with the history of heart failure, high blood pressure, and liver or kidney disease.
Q. Can Diclot Plus 50 mg/500 mg Tablet be taken with Vitamin B-complex?
Yes, Diclot Plus 50 mg/500 mg Tablet can be taken with Vitamin B-complex preparations. While Diclot Plus 50 mg/500 mg Tablet helps to relieve pain, Vitamin B-complex can help to correct the vitamin deficiency that might be causing the underlying painful condition.
Q. Is it safe to take a higher than the recommended dose of Diclot Plus 50 mg/500 mg Tablet?
No, taking a higher than the recommended dose of Diclot Plus 50 mg/500 mg Tablet can lead to increased chances of side effects like nausea, vomiting, heartburn, indigestion, diarrhea and can also damage your kidneys on long-term use. If you are experiencing increased severity of pain or the pain is not relieved by the recommended doses of this medicine, please consult your doctor for re-evaluation.
Q. What is the recommended storage condition for Diclot Plus 50 mg/500 mg Tablet?
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
