Manufacturer: Blue Cross Laboratories Ltd
Salt Composition : Chlorzoxazone(500mg), Diclofenac(50mg), Paracetamol(325mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Diclotal-MR Tablet should be taken with food. This will prevent you from getting an upset stomach. You should take it regularly as advised by your doctor. Do not take more or use it for a longer duration than recommended by your doctor.
Chlorzoxazone is a muscle relaxant. It acts by blocking nerve impulses or pain sensations that are sent to brain. Typically, it is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.
As with all NSAIDs, diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency
Paracetamol has a central analgesic effect that is mediated through activation of descending serotonergic pathways. Debate exists about its primary site of action, which may be inhibition of prostaglandin (PG) synthesis or through an active metabolite influencing cannabinoid receptors
Analysis of plasma samples indicated a rapid absorption and rapid elimination of chlorzoxazone. Average values of the elimination half-life and plasma clearance were 1.12 +/- 0.48 hr and 148.0 +/- 39.9 ml/min, respectively.
Diclofenac binds extensively to plasma albumin. The area under the plasma concentration-time curve (AUC) of diclofenac is proportional to the dose for oral doses between 25 to 150 mg. Substantial concentrations of drug are attained in synovial fluid, which is the proposed site of action for NSAIDs
It distributes rapidly and evenly throughout most tissues and fluids and has a volume of distribution of approximately 0.9L/kg. 10 to 20% of the drug is bound to red blood cells. Paracetamol is extensively metabolised (predominantly in the liver), the major metabolites being the sulphate and glucuronide conjugates.
Nausea
Vomiting
Heartburn
Stomach pain
Diarrhea
Loss of appetite
Dryness in mouth
Information regarding the use of Diclotal-MR Tablet during pregnancy is not available. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Diclotal-MR Tablet. Please consult your doctor.
Information regarding the use of Diclotal-MR Tablet during breastfeeding is not available. Please consult your doctor.
Buprenorphine Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Bupropion The metabolism of Chlorzoxazone can be decreased when combined with Bupropion
asthma.
fluid retention.
GI toxicity.
rash.
renal toxicities.
thrombosis.
porphyria.
anemia.
Despite its frequent coadministration with other drugs and widespread use, very few clinically significant drug interactions have been documented with paracetamol. Drugs that alter gastric emptying can alter paracetamol pharmacokinetics, but this does not result in toxicity in therapeutic use.
Do not chew, crush or break it. Diclotal-MR Tablet is to be taken with food.
Store below 30°C
If you miss a dose of Diclotal-MR Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
You have been prescribed Diclotal-MR Tablet to relieve pain due to muscle spasm.
This medicine is most effective when taken along with proper rest and physical therapy.
Avoid consuming alcohol when taking Diclotal-MR Tablet as it may cause excessive drowsiness and increase the risk of liver damage.
Older adults may have increased drowsiness, confusion, and higher risk of falling as a result of taking Diclotal-MR Tablet.
Do not take it with any other medicine containing acetaminophen (drugs for pain/fever or cough-and-cold) without asking your doctor first.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Diclotal-MR Tablet is to be taken with food.
Q. What is Diclotal-MR Tablet?
Diclotal-MR Tablet is a combination of three medicines: Diclofenac, Paracetamol, and Chlorzoxazone. This medication helps in relieving muscle pain. Chlorzoxazone is a muscle relaxant which works by acting on the central nervous system. Diclofenac and Paracetamol work by lowering the chemical substance (prostaglandins) in the body that causes pain and inflammation.
Q. Is it safe to use Diclotal-MR Tablet?
Diclotal-MR Tablet is safe for most of the patients. However, in some patients it may cause common side effects like nausea, vomiting, heartburn, stomach pain, diarrhea, loss of appetite, dryness in the mouth, weakness, sleepiness and other uncommon or rare side effects. Inform your doctor as soon as possible if you experience any persistent problem due to the medication.
Q. Can I stop taking Diclotal-MR Tablet when my pain is relieved?
Diclotal-MR Tablet should be continued if advised for a specific time duration by your doctor. However, it can be discontinued if you are using it for short-term pain relief.
Q. Can the use of Diclotal-MR Tablet cause nausea and vomiting?
Yes, the use of Diclotal-MR Tablet can cause nausea and vomiting. In case, you experience nausea while taking this medicine, take it with milk, food or with antacids. Avoid taking fatty or fried foods along with this medication. In case of vomiting, drink plenty of water or other fluids by taking small frequent sips. Talk to your doctor if vomiting persists and you notice signs of dehydration, like dark colored and strong-smelling urine and a low frequency of urination. Do not take any other medicine without speaking to your doctor.
Q. Can the use of Diclotal-MR Tablet cause dizziness?
Yes, the use of Diclotal-MR Tablet can cause dizziness (feeling faint, weak, unsteady or lightheaded) in some patients. If you feel dizzy or lightheaded, it is better to rest for sometime and resume once you feel better.
Q. Can the use of Diclotal-MR Tablet cause damage to kidneys?
Yes, the long-term use of Diclotal-MR Tablet can cause damage to the kidneys. Normal kidneys produce a chemical called prostaglandins that protect them from damage. Use of painkillers lowers the levels of prostaglandins in the body leading to kidney damage on long-term use. Use of painkillers is not recommended to patients with underlying kidney disease.
Q. Can I take a higher than the recommended dose of this medicine?
No, taking a higher than the recommended dose of Diclotal-MR Tablet can increase the risks of side effects. If you are experiencing increased severity of pain or if the pain is not relieved by the recommended doses, please consult your doctor for re-evaluation.
Q. What are the recommended storage conditions for Diclotal-MR Tablet?
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
