Manufacturer: Wockhardt Ltd
Salt Composition : Diclofenac(50mg), Paracetamol(325mg), Tizanidine(2mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Dipane MR 50mg/325mg/2mg Tablet should be taken with food. This will prevent you from getting an upset stomach. The dose and duration will depend on the severity of your condition. You should keep taking the medicine even if you feel better until the doctor says it is alright to stop using it.Using this medicine may cause few common side effects such as nausea, vomiting, diarrhea, stomach pain, heartburn, loss of appetite, dryness in the mouth, and sleepiness. If any of these side effects do not resolve with time or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the side effects. In general, you should try to use the smallest amount necessary to control your symptoms.
Dipane MR 50mg/325mg/2mg Tablet is a combination of three medicines: Paracetamol, Diclofenac, and Tizanidine. Paracetamol is an antipyretic (fever reducer) and Diclofenac is a non-steroidal antiinflammatory drug (NSAID). They work by blocking the release of certain chemical messengers in the brain that cause fever and pain respectively. Tizanidine is a muscle relaxant. It works on the centers in the brain and spinal cord to relieve muscle stiffness or spasm and to improve pain and movement of muscles.
Diclofenac binds extensively to plasma albumin. The area under the plasma concentration-time curve (AUC) of diclofenac is proportional to the dose for oral doses between 25 to 150 mg. Substantial concentrations of drug are attained in synovial fluid, which is the proposed site of action for NSAIDs.It distributes rapidly and evenly throughout most tissues and fluids and has a volume of distribution of approximately 0.9L/kg. 10 to 20% of the drug is bound to red blood cells. Paracetamol is extensively metabolised (predominantly in the liver), the major metabolites being the sulphate and glucuronide conjugates.The pharmacokinetics of tizanidine appeared to be linear in the 0-20 mg dose range, as indicated by the dose-proportional blood levels of total radioactivity as well as of parent drug. Absorbed tizanidine was almost completely metabolized before excretion, the major excretory route being via the kidneys.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Dipane MR
Nausea
Vomiting
Diarrhea
Stomach pain
Heartburn
Loss of appetite
Dryness in mouth
Sleepiness
Tiredness
Dizziness
Hypersensitivity to Dipane MR Tablet is a contraindication. In addition, Dipane MR Tablet should not be used if you have the following conditions:
Alcohol
Breastfeeding
Hepatic impairment
History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other nonsteroidal anti-inflammatory drugs
Hypersensitivity
Hypersensitivity to this drug
Pregnant
Severe renal impairment
Treatment of peri-operative pain in the setting of coronary artery bypass graft surgery
Information regarding the use of Dipane MR 50mg/325mg/2mg Tablet during pregnancy is not available. Please consult your doctor.
It is unsafe to consume alcohol with Dipane MR 50mg/325mg/2mg Tablet.
Information regarding the use of Dipane MR 50mg/325mg/2mg Tablet during breastfeeding is not available. Please consult your doctor.
Use with caution
Below 9years: Contraindicated
Diclofenac+Paracetamol+Tizanidine is used for muscular pain.Paracetamol is an antipyretic (fever reducer) and Diclofenac is a non-steroidal antiinflammatory drug (NSAID). They work by blocking the release of certain chemical messengers in the brain that cause fever and pain respectively. Tizanidine is a muscle relaxant. It works on the centers in the brain and spinal cord to relieve muscle stiffness or spasm and to improve pain and movement of muscles.
If you use other drugs or over the counter products at the same time, the effects of Dipane MR Tablet may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Dipane MR Tablet may interact with the following drugs and products:
Albuterol
Alcohol
Alprazolam
Angiotensin converting enzyme inhibitors
Aspirin
Celecoxib
Cholecalciferol
Clonazepam
Cyanocobalamin
Cyclosporine
Do not chew, crush or break it. Dipane MR 50mg/325mg/2mg Tablet is to be taken with food.
Store below 30°C
If you miss a dose of Dipane MR 50mg/325mg/2mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
This medicine is most effective when taken along with proper rest and physical therapy.
Avoid consuming alcohol when taking Dipane MR 50mg/325mg/2mg Tablet as it may cause excessive drowsiness and increase the risk of liver damage.
Older adults may have increased drowsiness, confusion, and higher risk of falling as a result of taking Dipane MR 50mg/325mg/2mg Tablet.
Do not take it with any other medicine containing acetaminophen (drugs for pain/fever or cough-and-cold) without asking your doctor first.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Dipane MR 50mg/325mg/2mg Tablet is to be taken with food.
