Manufacturer: Entod Pharmaceuticals Ltd
Salt Composition : Paracetamol/Acetaminophen(325mg), Tramadol(37.5mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Dolofirst 325 mg/37.5 mg Tablet can be taken with or without food. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. You should keep taking the medicine even if you feel better until the doctor says it is alright to stop using it.
Dolofirst 325 mg/37.5 mg Tablet is a combination of two medicines: Paracetamol/Acetaminophen and Tramadol. Paracetamol/Acetaminophen is an analgesic (pain reliever) which works by blocking the release of certain chemical messengers that cause pain.
Paracetamol is readily absorbed from the gastrointestinal tract with peak plasma concentrations occurring about 30 minutes to 2 hours after ingestion. It is metabolised in the liver (90-95%) and excreted in the urine mainly as the glucuronide and sulphate conjugates. Less than 5% is excreted as unchanged paracetamol,Tramadol is rapidly distributed in the body; plasma protein binding is about 20%. Tramadol is mainly metabolised by O- and N-demethylation and by conjugation reactions forming glucuronides and sulfates. Tramadol and its metabolites are mainly excreted via the kidneys. The mean elimination half-life is about 6 hours.
Contraindicated
Dolofirst 325 mg/37.5 mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is unsafe to consume alcohol with Dolofirst 325 mg/37.5 mg Tablet.
Use with caution
Use with caution Below 9years: Contraindicated
Dolofirst 325 mg/37.5 mg Tablet is a pain-relieving medicine. It is used in various conditions such as muscle ache, back pain, joint pain, menstrual cramps, and toothache.
Take it as it is prescribed to get the most benefit. Do not take more or for longer than needed as that can be dangerous. In general, you should take the lowest dose that works, for the shortest possible time. This will help you to go about your daily activities more easily and have a better, more active, quality of life.
Dolofirst 325 mg/37.5 mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
If you miss a dose of Dolofirst 325 mg/37.5 mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Use only for severe acute pain for not more than 5 days.
Prolonged use may result in physical and psychological dependence even at recommended dosages.
It causes sleepiness or drowsiness. If this happens to you, do not drive or use machinery.
It is better to take with food to avoid an upset stomach.
Your doctor may adjust your dose if you have liver or kidney disease.
In case of overdose, tell your doctor immediately.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Dolofirst 325 mg/37.5 mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Q. Is it safe to use Dolofirst 325 mg/37.5 mg Tablet?
Yes, Dolofirst 325 mg/37.5 mg Tablet is safe for most of the patients. However, in some patients it may cause common side effects like nausea, vomiting, constipation, weakness, dizziness, dryness in the mouth, sleepiness and other uncommon and rare side effects. Inform your doctor if you experience any persistent problem while taking this medication.
Q. Can I stop taking the medication when my pain is relieved?
Dolofirst 325 mg/37.5 mg Tablet is usually recommended for short-term use and can be discontinued when your pain is relieved. However, it is advisable that it should be taken only as suggested by your doctor.
Q. Can the use of Dolofirst 325 mg/37.5 mg Tablet cause constipation?
Yes, the use of Dolofirst 325 mg/37.5 mg Tablet can cause constipation. To prevent constipation eat high-fiber foods like vegetables, fruits and cereals. Drink plenty of water. Exercise regularly by engaging in activities like swimming, jogging or take a short walk. Talk to your doctor about taking some medicines to treat constipation if this persists for a long time.
Q. Can the use of Dolofirst 325 mg/37.5 mg Tablet cause dizziness?
Yes, the use of Dolofirst 325 mg/37.5 mg Tablet can cause dizziness (feeling faint, weak, unsteady or lightheaded) in some patients. If you feel dizzy or lightheaded, it is better to rest for some time and resume once you feel better. Do not drive or use any machines.
Q. Can the use of Dolofirst 325 mg/37.5 mg Tablet cause dry mouth?
Yes, the use of Dolofirst 325 mg/37.5 mg Tablet can cause dry mouth. If you experience dry mouth, drink plenty of water. Take regular sips during the day and keep some water on the bedside at night. You may use some lip balm if your lips are also dry.
Q. Can the use of Dolofirst 325 mg/37.5 mg Tablet cause damage to liver?
Dolofirst 325 mg/37.5 mg Tablet is usually safe to use in the recommended dose. However, an overdose of Dolofirst 325 mg/37.5 mg Tablet can damage your liver. Avoid drinking alcohol while taking this medicine, it may increase your risk of liver damage.
Q. Can I take a higher than the recommended dose of this medicine?
No, taking a higher than the recommended dose of Dolofirst 325 mg/37.5 mg Tablet can increase the risks of side effects and liver damage. If you are experiencing increased severity of pain or if the pain is not relieved by the recommended doses, please consult your doctor for re-evaluation.
Q. What are the recommended storage conditions for Dolofirst 325 mg/37.5 mg Tablet?
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
