Manufacturer: Pfizer Ltd
Salt Composition : Piroxicam(20mg/ml)
Packet of 5 Injection
(Inclusive of all taxes)
Dolonex Injection 2ml is generally administered by a healthcare professional. You should not self-administer this medicine at home. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. You should keep receiving the medicine until the doctor says it is okay to stop using the medicine.
Dolonex Injection 2ml is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that are responsible for inflammation (pain and swelling).
Piroxicam is highly bound (approximately 99%) to plasma proteins and has a small distribution volume (approximately 10 l). Despite its high plasma binding, the drug readily penetrates into synovial fluid. Piroxicam has a long elimination half-life of about 50 h.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Dolonex
Injection site reactions (pain, swelling, redness)
Vomiting
Stomach pain
Nausea
Headache
Dizziness
systemic mastocytosis.
anemia.
increased risk of bleeding due to clotting disorder.
an increased risk of bleeding.
alcoholism.
high blood pressure.
a heart attack.
chronic heart failure.
Dolonex Injection 2ml is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Caution is advised when consuming alcohol with Dolonex Injection 2ml. Please consult your doctor.
Dolonex Injection 2ml is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Use with caution
Below 9years: Contraindicated
Piroxicam is indicated for symptomatic relief of osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis. Due to its safety profile (see sections 4.2, 4.3 and 4.4), piroxicam is not a first line option should an NSAID be indicated.
PIROXICAM may have interaction with ibuprofen, naproxen, and aspirin (used to relieve pain), duloxetine (used to treat depression), metoprolol, atenolol, and lisinopril (used to treat high blood pressure), warfarin (used to prevent blood clotting), celecoxib, prednisone, and meloxicam (used to treat arthritis), sertraline (used to treat depression), and drugs used to treat high blood pressure and fluid retention.
Kindly do not self administer.
Store below 30°C
If you miss a dose of Dolonex Injection 2ml, consult your doctor.
Consult a doctor before taking any medicines.
Dolonex Injection 2ml helps relieve pain and swelling of various joints and muscles.
It may cause dizziness and fatigue. Do not drive or do anything requiring concentration until you know how it affects you.
Avoid consuming alcohol when taking this medicine as it may cause excessive drowsiness.
Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. What is the difference between Dolonex Injection 2ml and diclofenac?
Both Dolonex Injection 2ml and diclofenac are pain killers. However, piroxicam is a non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain) inhibitor whereas diclofenac has a bit more selectivity to a COX-2 enzyme. This selectivity of diclofenac is supposed to decrease the side effects as compared to Dolonex Injection 2ml.
Q. What is the difference between Dolonex Injection 2ml and naproxen?
Both Dolonex Injection 2ml and naproxen are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, gastric side effects are lesser with naproxen as compared to Dolonex Injection 2ml.
Q. What is the difference between Dolonex Injection 2ml and meloxicam?
Both Dolonex Injection 2ml and meloxicam are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, acute gastric side effects are lesser with meloxicam as compared to Dolonex Injection 2ml.
Q. What is the difference between Dolonex Injection 2ml and ketoprofen?
Both Dolonex Injection 2ml and ketoprofen are pain killers. Both are non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain). Research studies have shown ketoprofen topical gel is better and effective as compared to Dolonex Injection 2ml. Ketoprofen gel also showed excellent tolerability.
Q. What is the difference between Dolonex Injection 2ml and tramadol?
Dolonex Injection 2ml is a COX (cyclooxygenase -an enzyme responsible for inflammation and pain) whereas Tramadol is a narcotic-like painkiller. Tramadol is a habit forming medicine.
Q. What is the difference between Dolonex Injection 2ml and nimesulide?
Both Dolonex Injection 2ml and nimesulide are pain killers. However, Dolonex Injection 2ml is a non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain) inhibitor whereas nimesulide is selective to the COX-2 enzyme. This selectivity of nimesulide is supposed to decrease the side effects as compared to piroxicam. It should not be used in children below 12 years of age.
Q. Can Dolonex Injection 2ml be used in the treatment of chikungunya?
Usually, the platelet count does not dip in cases of chikungunya and painkillers like piroxicam can lead to the risk of increased bleeding tendency. So refrain from taking Dolonex Injection 2ml or any painkiller in the case of any fever with joint pain. Consult your doctor before starting Dolonex Injection 2ml.
Q. Are Dolonex Injection 2ml and aspirin same?
No. Dolonex Injection 2ml and aspirin are not same. They belong to the same class of drugs known as COX (cyclooxygenase) inhibitors. They both are anti-inflammatory and analgesic.
Q. Can Dolonex Injection 2ml be used along with dexamethasone?
No. Dolonex Injection 2ml should not be used with dexamethasone. They both increase each other's toxicity. There is an increased risk of GI ulceration.
Q. Can Dolonex Injection 2ml be used with methocarbamol?
Yes. Methocarbamol can be used with Dolonex Injection 2ml as no serious side effects are known. Inform your doctor before starting any of the medication.
Q. Can Dolonex Injection 2ml be used along with paracetamol?
Yes. Paracetamol can be used with Dolonex Injection 2ml as no serious side effects are known. Inform your doctor before starting any of the medication.
Q. Is Dolonex Injection 2ml a NSAID?
Yes. Dolonex Injection 2ml is a non-steroidal anti-inflammatory drug (NSAID).
Q. Is Dolonex Injection 2ml a sulfa drug?
Dolonex Injection 2ml is a sulphur containing compound. Dolonex Injection 2ml can cause serious adverse events in sensitive individuals. It can cause severe skin reactions like Steven Johnson Syndrome. Do inform your doctor if you have any kind of allergies.
Q. Is Dolonex Injection 2ml a blood thinner?
No. Dolonex Injection 2ml is not a blood thinner. It is a pain killer. It should be avoided in a patient with a bleeding disorder.
Q. Is Dolonex Injection 2ml a muscle relaxant?
No. Dolonex Injection 2ml is not a muscle relaxant. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme.
Q. Is Dolonex Injection 2ml a narcotic?
No. Dolonex Injection 2ml is not a narcotic. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme to decrease the pain and inflammation.
Q. Can Dolonex Injection 2ml be used in hypertension?
No. Dolonex Injection 2ml is not a medication to control hypertension. It is important to note that Dolonex Injection 2ml decreases the effectiveness of the antihypertensive medication when given together. Inform your doctor if you are taking antihypertensive medications before starting Dolonex Injection 2ml.
Q. Can Dolonex Injection 2ml be used along with Losartan?
No. Dolonex Injection 2ml should not be combined with Losartan. It is important to note that Dolonex Injection 2ml decreases the effectiveness of the antihypertensive medication like losartan when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Dolonex Injection 2ml.
Q. Can Dolonex Injection 2ml be used with Lisinopril?
No. Dolonex Injection 2ml should be avoided with lisinopril. It is important to note that piroxicam decreases the effectiveness of the antihypertensive medication like lisinopril when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Dolonex Injection 2ml.
Q. Can Dolonex Injection 2ml be used with calcium channel blocker?
Yes. Dolonex Injection 2ml can be taken with calcium channel blocker. NSAIDs have been observed to reduce the effectiveness of all antihypertensive drugs except calcium channel blockers (ref: White 2007)
Q. Can Dolonex Injection 2ml be used with Tizanidine?
Yes, Dolonex Injection 2ml can be combined with tizanidine. Piroxicam is a pain killer and tizanidine is a skeletal muscle relaxant. It is used in the condition like a backache.
Q. Why is beta cyclodextrin added to Dolonex Injection 2ml?
Yes. Dolonex Injection 2ml can be combined with beta-cyclodextrin. Research has shown that combining Dolonex Injection 2ml with beta-cyclodextrin leads to faster onset of action of piroxicam and reduced gastric side effects.
Q. Are there any alternatives of Dolonex Injection 2ml?
Yes. There are alternatives to Dolonex Injection 2ml. Pain killers are prescribed according to the disease condition. Consult your doctor before starting piroxicam or changing it to other medication.
Q. What are the contraindications for Dolonex Injection 2ml?
Contraindications to piroxicam are an allergy, bleeding tendency, duodenal/gastric/peptic ulcer, stomatitis, Systemic Lupus Erythematosus (SLE), ulcerative colitis, upper GI disease, late pregnancy, cardiac disease, hepatic impairment, renal impairment.
Q. Can Dolonex Injection 2ml be used in the treatment of allergy?
No. Dolonex Injection 2ml is not a drug to treat allergy. It is a pain killer.
Q. How long does Dolonex Injection 2ml work?
Dolonex Injection 2ml is a long acting drug. Once the daily dose is enough for the relief of pain but it depends from person to person as the effectiveness of piroxicam increases when given for few weeks.
Q. Can you get high by using Dolonex Injection 2ml?
No. Dolonex Injection 2ml is not known to cause high. It is a non-narcotic painkiller.
Q. Can Dolonex Injection 2ml be used to treat menstrual cramp?
Dolonex Injection 2ml is not approved for the treatment of menstrual cramps. Research studies have shown that piroxicam is quite effective in significantly decreasing the menstrual cramps.
Q. Can I use Dolonex Injection 2ml for a migraine?
Dolonex Injection 2ml is not approved for the treatment of migraine. Research studies have shown that Dolonex Injection 2ml is effective in significantly decreasing the pain associated with migraine without aura.
Q. Is Dolonex Injection 2ml effective in back pain management?
Yes. It can be given for decreasing the back pain. However, you should consult your doctor for the exact cause of your back pain and then start the treatment. Do not self-medicate yourself with Dolonex Injection 2ml as the cause of back pain can be different for different person.
Q. Is Dolonex Injection 2ml affective in gout management?
Yes. Dolonex Injection 2ml can be given for the treatment of acute gout. Research studies have shown Dolonex Injection 2ml to be highly effective in the treatment of acute gout.
Q. Can you donate blood when on the medication with Dolonex Injection 2ml?
Yes. You can donate blood when on Dolonex Injection 2ml. Do inform your doctor before donating blood.
Q. Can I use Dolonex Injection 2ml if I am a diabetic?
Dolonex Injection 2ml in a diabetic patient can only be taken only by consulting a doctor because these medicines have the propensity to cause renal failure when taken for a long period. Diabetes itself causes renal Dolonex Injection 2ml so taking piroxicam can lead to increased risk of renal failure by many folds.
Q. Can I use Dolonex Injection 2ml if I have a deranged renal function?
No. Dolonex Injection 2ml should not be taken if you have a abnormal renal function because long-term administration of NSAIDs has resulted in renal papillary necrosis and another renal injury.
Q. Can Dolonex Injection 2ml lead to skin reactions?
Yes. Dolonex Injection 2ml is known to cause skin reactions which can be very severe such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. These serious events may occur without warning. You should inform your doctor if you feel you have a mild rash and immediately discontinue the drug.
Q. Can I use Dolonex Injection 2ml if I am pregnant?
No. Dolonex Injection 2ml should not be taken in pregnancy. It causes premature closure of the ductus arteriosus which can lead to fetal heart failure and death of the baby.
Q. Can I use Dolonex Injection 2ml if I have peptic ulcer disease?
No. Dolonex Injection 2ml is contraindicated in cases of active peptic ulcer disease. Dolonex Injection 2ml is known to cause gastric ulceration and bleeding.
Q. Can I use Dolonex Injection 2ml if I have asthma?
Some patients with asthma are hypersensitive to non-steroidal anti-inflammatory (NSAID) drugs like aspirin which can lead to acute attacks of asthma. Consult your doctor before starting this medication.
Q. Can Dolonex Injection 2ml lead to difficulty in conception?
Yes. Dolonex Injection 2ml can sometimes cause reversible infertility. Piroxicam by its mechanism of action may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Consult your doctor before starting this medication.
Q. Can Dolonex Injection 2ml be used with diuretics?
No. Dolonex Injection 2ml should not be used with diuretics. Dolonex Injection 2ml reduces the natriuretic effect of furosemide and thiazides diuretics in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis.
Q. Can Dolonex Injection 2ml be used with lithium?
No. Dolonex Injection 2ml should not be used with lithium. Dolonex Injection 2ml leads to an elevation of plasma lithium levels and a reduction in renal lithium clearance. This is because of inhibition of renal prostaglandin synthesis by the NSAID. Consult and inform your doctor before starting this medication.
Q. Can Dolonex Injection 2ml be used with warfarin?
No. Dolonex Injection 2ml should be avoided with warfarin as they both lead to increase in bleeding tendencies. Inform your doctor if you are taking any of the medications. If given together then the therapy should be monitored closely.
Q. What increases the chances of getting a gastric ulcer when I am already taking Dolonex Injection 2ml?
The chances of gastric ulceration increases if you take medicines like corticosteroids and anticoagulants. Long term use, alcohol, smoking and old age are few other factors which can increase the chances of ulceration.
Q. Who should not take a Non-Steroidal Anti-Inflammatory Drug (NSAID)/ Dolonex Injection 2ml?
Patients who had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine or for pain right before or after heart bypass surgery.
Q. What are the serious side effects of Dolonex Injection 2ml?
GI discomfort and, rarely, serious GI side effects, such as ulcers and bleeding, serious skin side effects such as exfoliative, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis, liver failure, renal damage.
