Manufacturer: Tidal Laboratories Pvt Ltd
Salt Composition : Tramadol(37.5mg), Paracetamol(325mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Dolosafe 37.5mg/325mg Tablet should be taken in the dose and duration advised by your doctor. It may be taken with or without food. In case you experience stomach upset then take the medicine with food. It is important not to miss doses and to keep taking them until your doctor tells you it is safe to stop. Do not stop using this medicine without asking your doctor.
Dolosafe 37.5mg/325mg Tablet is a combination of two medicines: Tramadol and Paracetamol which relieve severe pain. Tramadol is an opoid analgesic (pain reliever) which works by blocking the transmission of pain signals to the brain to lower pain perception.
Tramadol is rapidly distributed in the body; plasma protein binding is about 20%. Tramadol is mainly metabolised by O- and N-demethylation and by conjugation reactions forming glucuronides and sulfates. Tramadol and its metabolites are mainly excreted via the kidneys. The mean elimination half-life is about 6 hours.It distributes rapidly and evenly throughout most tissues and fluids and has a volume of distribution of approximately 0.9L/kg. 10 to 20% of the drug is bound to red blood cells. Paracetamol is extensively metabolised (predominantly in the liver), the major metabolites being the sulphate and glucuronide conjugates.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Dolosafe
Sleepiness
Vomiting
Weakness
Dizziness
Nausea
Dryness in mouth
Constipation
caloric undernutrition
acute liver failure
liver problems
a condition where the body is unable to maintain adequate blood flow called shock
acetaminophen overdose
acute inflammation of the liver due to hepatitis C virus
low blood sugar
decreased function of the adrenal gland
low amount of sodium in the blood
symptoms from alcohol withdrawal
suicidal behavior
suicidal thoughts
alcoholism
alcohol intoxication
drug abuse
depression
serotonin syndrome, a type of disorder with high serotonin levels
a low seizure threshold
asthma
decreased lung function
Dolosafe 37.5mg/325mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is unsafe to consume alcohol with Dolosafe 37.5mg/325mg Tablet.
Dolosafe 37.5mg/325mg Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Consult a doctor immediately if the baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, breathing problems, or limpness.
Use with caution
Below 9years: Contraindicated
Tramadol/Paracetamol tablets are indicated for the symptomatic treatment of moderate to severe pain. The use of Tramadol/Paracetamol should be restricted to patients whose moderate to severe pain is considered to require a combination of tramadol and paracetamol
PARACETAMOL+TRAMADOL may interact with pain medications such as pentazocine, naltrexone, monoamine oxidase inhibitors (MAO) such as phenelzine, procarbazine, isocarboxazid, and rasagiline, antidepressants such as fluoxetine, paroxetine, drugs used to treat seizures such as carbamazepine, HIV drugs such as ritonavir, and antifungals such as itraconazole.
Do not chew, crush or break it. Dolosafe 37.5mg/325mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
If you miss a dose of Dolosafe 37.5mg/325mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Dolosafe 37.5mg/325mg Tablet is used to treat various painful conditions.
It is better to take it with milk or food to prevent stomach upset.
Drink plenty of water while taking this medicine.
Do not take any other pain medicine without asking your doctor first.
During long-term treatment, your doctor may want to take regular blood tests to monitor your liver function.
Inform your doctor if you have a history of stomach ulcers, heart diseases, high blood pressure, and liver or kidney disease.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Dolosafe 37.5mg/325mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
