Doxiglan 50mg (Injection)

Manufacturer: Gland Pharma Limited

Salt Composition : Doxorubicin(Plain)(50mg)

Prescription
Prescription Required: Consult the Doctor & Get Your ePrescription

It is given as a drip or infusion vein with extreme caution by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. It makes contraceptive pills less effective, so it advised to both male and female to use reliable contraception during the treatment.



Basic Information

Mechanism Of Action

Doxiglan 50mg Injection is an anti-cancer medication. It works by suppressing the activity of an enzyme (topoisomerase II) involved in DNA multiplication of the cancer cells. It also forms harmful chemicals (free radicals) which cause DNA damage. This slows the growth of cancer cells and eventually kills them.


Pharmacokinets

Up to several weeks after administration, significant concentrations of doxorubicin have been found in haematopoietic cells and in several other tissues. The maximum cellular doxorubicin concentrations reached in vivo remain significantly below those at which all clonogenic leukaemic cells are killed in vitro.

Side Effects

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Doxiglan

Vomiting

Allergic reaction

Nausea

Mouth sore

Hair loss

Stomach pain

Eye disorder

Increased thirst

Arrhythmia (irregular heartbeats)

Nail disorder

Contra Indications

a bad infection

glucose-6-phosphate dehydrogenase (G6PD) deficiency

anemia

decreased blood platelets

low levels of a type of white blood cell called neutrophils

heart attack within the last 30 days

cardiomyopathy, a disease of the heart muscle

atrioventricular block, a type of slow heart rhythm disorder

bundle branch block

abnormal heart rhythm

heart failure

inflammation of the middle tissue heart muscle

high amount of bilirubin in the blood

erythrodysesthesia or tingling, pain, redness, and edema in the hands and feet

pregnancy

a patient who is producing milk and breastfeeding

dysfunction of left ventricle of heart without symptoms

anemia from pyruvate kinase and G6PD deficiencies

Child-Pugh class B liver impairment

Child-Pugh class C liver impairment

Pregnancy Related Information

Doxiglan 50mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.


Product And Alcohol Interaction

It is not known whether it is safe to consume alcohol with Doxiglan 50mg Injection. Please consult your doctor.


Breast Feeding Related Information

Doxiglan 50mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.


Children Related Information

Use with caution

Below 9years: Contraindicated


Indications

Doxorubicin is also indicated for the treatment of cancers of the ovary, prostate, stomach, thyroid; small cell cancer of lung, liver; squamous cell cancer of head and neck; multiple myeloma, Hodgkin's disease, lymphomas, acute lymphocytic leukemia (ALL), and acute myeloid leukemia (AML).

Interactions

If you use other drugs or over the counter products at the same time, the effects of Doxiglan Injection may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Doxiglan Injection may interact with the following drugs and products:

Aprepitant

Cholecalciferol

Cyclophosphamide

Dexamethasone

Diphenhydramine

Docetaxel

Docusate

Esomeprazole

Hydromorphone

Loratadine

Typical Dosage

Kindly do not self administer.

Storage Requirements

Store in a refrigerator (2 - 8°C). Do not freeze.


Effects Of Missed Dosage

If you miss a dose of Doxiglan 50mg Injection, please consult your doctor.

Effects Of Overdose

Consult a doctor before taking any medicines.

Expert Advice

Doxiglan 50mg Injection is given as an injection into the vein under the supervision of a doctor.

Do not skip any dose and complete the course as suggested by your doctor.

Use an effective method of birth control to avoid pregnancy while taking this medication.

Your doctor may get regular blood tests done to monitor your electrolyte levels, liver function, blood cell count in your blood.

Inform your doctor if you experience fever, chills, shortness of breath and swelling of face or lips. 

How To Use

Your doctor or nurse will give you this medicine. Kindly do not self administer.


FAQs

Q. How does doxorubicin work?

Doxorubicin is anti-cancer or antineoplastic chemotherapy drug that belongs to a class of medications called anthracyclines. It slows down or stops the growth of cancer cells by interfering with DNA of the cancer cells. This helps treat the cancer.

Q. Is doxorubicin a vesicant?

Yes doxorubicin is a vesicant (irritant).