Manufacturer: Parenteral Drugs India Ltd
Salt Composition : Doxorubicin(Liposomal)(50mg)
Doxopar 50mg Injection can be used in both adults and children. It is given as injection into vein with extreme caution by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. It makes contraceptive pills less effective, so it advised to use reliable contraception during and after 6 months of the treatment.
Doxopar 50mg Injection is an anti-cancer medication. It works by damaging the genetic material (DNA) of the cancer cells and stops their growth and multiplication.
Up to several weeks after administration, significant concentrations of doxorubicin have been found in haematopoietic cells and in several other tissues. The maximum cellular doxorubicin concentrations reached in vivo remain significantly below those at which all clonogenic leukaemic cells are killed in vitro.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Doxopar
Nausea
Vomiting
Rash
Weakness
Low blood platelets
Fatigue
Fever
Decreased white blood cell count (neutrophils)
Loss of appetite
Anemia (low number of red blood cells)
Constipation
Stomatitis (Inflammation of the mouth)
Diarrhea
Painful blisters on hands and feet
a bad infection
glucose-6-phosphate dehydrogenase (G6PD) deficiency
anemia
decreased blood platelets
low levels of a type of white blood cell called neutrophils
heart attack within the last 30 days
cardiomyopathy, a disease of the heart muscle
atrioventricular block, a type of slow heart rhythm disorder
bundle branch block
abnormal heart rhythm
heart failure
inflammation of the middle tissue heart muscle
high amount of bilirubin in the blood
erythrodysesthesia or tingling, pain, redness, and edema in the hands and feet
pregnancy
a patient who is producing milk and breastfeeding
dysfunction of left ventricle of heart without symptoms
anemia from pyruvate kinase and G6PD deficiencies
Child-Pugh class B liver impairment
Child-Pugh class C liver impairment
Doxopar 50mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Doxopar 50mg Injection. Please consult your doctor.
Information regarding the use of Doxopar 50mg Injection during breastfeeding is not available. Please consult your doctor.
Use with caution
Below 9years: Contraindicated
Doxorubicin is also indicated for the treatment of cancers of the ovary, prostate, stomach, thyroid; small cell cancer of lung, liver; squamous cell cancer of head and neck; multiple myeloma, Hodgkin's disease, lymphomas, acute lymphocytic leukemia (ALL), and acute myeloid leukemia (AML).
If you use other drugs or over the counter products at the same time, the effects of Doxopar Injection may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Doxopar Injection may interact with the following drugs and products:
Aprepitant
Cholecalciferol
Cyclophosphamide
Dexamethasone
Diphenhydramine
Docetaxel
Docusate
Esomeprazole
Hydromorphone
Loratadine
Kindly do not self administer.
Store in a refrigerator (2 - 8°C). Do not freeze.
If you miss a dose of Doxopar 50mg Injection, please consult your doctor.
Consult a doctor before taking any medicines.
Doxopar 50mg Injection helps treat cancer of the breast, blood, and ovaries.
It is given through a drip into a vein (intravenous infusion) by a doctor or nurse.
It may make you feel tired or sleepy. Do not drive or do anything that requires mental focus until you know how it affects you.
Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for 6 months after stopping treatment.
Inform your doctor if you notice sores, discolouration or any discomfort in your mouth.
Your doctor may get regular blood tests done to monitor your blood cells, liver, and heart function during treatment with this medicine.
Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. How does doxorubicin work?
Doxorubicin is anti-cancer or antineoplastic chemotherapy drug that belongs to a class of medication called anthracyclines. It slows down or stops the growth of cancer cells by interfering with DNA of the cancer cell.
Q. What is liposomal doxorubicin?
The molecules of doxorubicin are coated in a fatty capsule called as liposome. This liposome protects the body and allows the doxorubicin to remain in the blood circulation for a longer duration. This means that more amount of drug can be delivered to the cancer cells with less side effects.
