Manufacturer: Khandelwal Laboratories Pvt Ltd
Salt Composition : Doxorubicin(Plain)(50mg)
It is given as a drip or infusion vein with extreme caution by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. It makes contraceptive pills less effective, so it advised to both male and female to use reliable contraception during the treatment.
Doxorubicin binds to nucleic acids, presumably by specific intercalation of the planar anthracycline nucleus with the DNA double helix. The anthracycline ring is lipophilic, but the saturated end of the ring system contains abundant hydroxyl groups adjacent to the amino sugar, producing a hydrophilic center.
Up to several weeks after administration, significant concentrations of doxorubicin have been found in haematopoietic cells and in several other tissues. The maximum cellular doxorubicin concentrations reached in vivo remain significantly below those at which all clonogenic leukaemic cells are killed in vitro.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Doxorubin
Vomiting
Allergic reaction
Nausea
Mouth sore
Hair loss
Stomach pain
Eye disorder
Increased thirst
Arrhythmia (irregular heartbeats)
Nail disorder
a bad infection
glucose-6-phosphate dehydrogenase (G6PD) deficiency
anemia
decreased blood platelets
low levels of a type of white blood cell called neutrophils
heart attack within the last 30 days
cardiomyopathy, a disease of the heart muscle
atrioventricular block, a type of slow heart rhythm disorder
bundle branch block
abnormal heart rhythm
heart failure
inflammation of the middle tissue heart muscle
high amount of bilirubin in the blood
erythrodysesthesia or tingling, pain, redness, and edema in the hands and feet
pregnancy
a patient who is producing milk and breastfeeding
dysfunction of left ventricle of heart without symptoms
anemia from pyruvate kinase and G6PD deficiencies
Child-Pugh class B liver impairment
Child-Pugh class C liver impairment
Doxorubin 50 Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Doxorubin 50 Injection. Please consult your doctor.
Doxorubin 50 Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Use with caution
Below 9years: Contraindicated
Doxorubicin is also indicated for the treatment of cancers of the ovary, prostate, stomach, thyroid; small cell cancer of lung, liver; squamous cell cancer of head and neck; multiple myeloma, Hodgkin's disease, lymphomas, acute lymphocytic leukemia (ALL), and acute myeloid leukemia (AML).
If you use other drugs or over the counter products at the same time, the effects of Doxorubin 50 Injection may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Doxorubin 50 Injection may interact with the following drugs and products:
Aprepitant
Cholecalciferol
Cyclophosphamide
Dexamethasone
Diphenhydramine
Docetaxel
Docusate
Esomeprazole
Hydromorphone
Loratadine
Kindly do not self administer.
Store in a refrigerator (2 - 8°C). Do not freeze.
If you miss a dose of Doxorubin 50 Injection, please consult your doctor.
Consult a doctor before taking any medicines.
Doxorubin 50 Injection is given as an injection into the vein under the supervision of a doctor.
Do not skip any dose and complete the course as suggested by your doctor.
Use an effective method of birth control to avoid pregnancy while taking this medication.
Your doctor may get regular blood tests done to monitor your electrolyte levels, liver function, blood cell count in your blood.
Inform your doctor if you experience fever, chills, shortness of breath and swelling of face or lips.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. How does doxorubicin work?
Doxorubicin is anti-cancer or antineoplastic chemotherapy drug that belongs to a class of medications called anthracyclines. It slows down or stops the growth of cancer cells by interfering with DNA of the cancer cells. This helps treat the cancer.
Q. Is doxorubicin a vesicant?
Yes doxorubicin is a vesicant (irritant).
