Manufacturer: Lupin Ltd
Salt Composition : Insulin Lispro(0.25), Insulin Lispro Protamine(0.75)
Eglucent Mix 25 Kwikpen 100IU/ml is normally prescribed along with a long-acting type of insulin or other diabetes medicines. Your doctor or nurse will teach you the correct way of injecting it under the skin. It should be taken 15 minutes before a meal or within 20 minutes after starting a meal. Don’t stop taking it unless your doctor tells you to.
It is only part of a treatment program that should also include a healthy diet, regular exercise, and weight reduction as advised by your doctor. Check your blood sugar levels regularly, keep track of your results and share them with your doctor. This is very important to work out the correct dose of the medicine for you.
The most common side effect of this medicine is low blood sugar levels (hypoglycemia). To prevent this, it's important to always inject the correct dose of medicine only, have regular meals, and monitor your blood sugar levels regularly. Drinking excessive alcohol can also lead to a fall in your blood sugar levels. Other side effects include allergy at the injection site like redness, swelling, or hard lumps (lipodystrophy). Some people may also notice itching and rash while taking it.
Do not use this medicine when you have low blood sugar levels (hypoglycemia). Tell your doctor if you have ever had kidney, liver or heart problems before starting treatment. Pregnant or breastfeeding women should also consult their doctor as the dose may need to be changed.
This medicine lowers blood sugars by stimulating glucose uptake by cells, tissue and muscles, especially by skeletal muscles and fat and by inhibiting glucose production by the liver.
Insulin lispro is a rapid-acting insulin analogue used to mimic postprandial insulin spikes in diabetic individuals. The onset of action of insulin lispro is 10-15 minutes. Its activity peaks 60 minutes following subcutaneous injection and its duration of action is 4-5 hours.The pharmacokinetics of insulin lispro reflect a compound that is rapidly absorbed, and achieves peak blood levels 30 to 70 minutes following subcutaneous injection. The pharmacokinetics of insulin lispro protamine suspension are consistent with those of an intermediate acting insulin such as NPH.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Eglucent Mix
Hypoglycemia (low blood glucose level)
Weight gain
Infusion site reaction
Auto-antibody formation
If you are allergic to insulin or any of the ingredients of this medicine
If you are suffering from hypoglycemia (low blood sugar level).
Eglucent Mix 25 Kwikpen 100IU/ml is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
It is unsafe to consume alcohol with Eglucent Mix 25 Kwikpen 100IU/ml.
Eglucent Mix 25 Kwikpen 100IU/ml should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
Use with caution
Below 9years: Contraindicated
Insulin Lispro+Insulin Lispro Protamine is used in the treatment of diabetes mellitus (Type 1 & Type 2). It is indicated in patients with diabetes mellitus who require insulin for the maintenance of normal glucose homeostasis.
You may have symptoms of low blood sugar if you are taking other medicines for diabetes, depression (fluoxetine), medicines for fever and pain (salicylates), ramipril, lisinopril
You may have high blood sugar if you are taking oral contraceptives, thiazide, steroids, thyroxine, medicines used to treat severe diarrhoea and abnormal growth of body organs like octreotide, lanreotide
If you are taking a medicine pioglitazone to treat diabetes, be cautious, as some cases of heart attack and heart failure have been reported
Some medicines block your body's response to low blood sugar, so you may not experience symptoms like headache, hunger pangs, sweating, anxiety when your blood sugar drops. This can lead to a serious fall in blood sugar. Inform your doctor if you are on medicines like Betablockers (Metoprolol, Propranolol, Atenolol), Clonidine, Guanethidine and Reserpine.
Kindly do not self administer.
Store in a refrigerator (2 - 8°C). Do not freeze.
If you have missed a dose of Eglucent Mix 25 Kwikpen 100IU/ml, your blood sugar level may become too high (hyperglycemia). Check your blood sugar and then take the next dose accordingly.
Consult a doctor before taking any medicines.
Take it 15 minutes before a meal or within 20 minutes after starting a meal.
Injection below the skin of the abdomen results in faster absorption as compared to other injection sites such as skin of the upper arms, thighs, or buttocks. After injection, the site of injection should not be massaged.
Injection sites must be rotated to prevent hard lumps from developing at one site.
Change to another type or brand of insulin should be done under strict medical supervision as it may require a change in dosage.
Hypoglycemia (low blood sugar level) may occur when taken along with other antidiabetic medicines, alcohol or on delaying/skipping a meal. Carry a sugar source with you for immediate relief.
Do not share your insulin device with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.
Opened vials / cartridges stay good at room temperature for up to 4 weeks, while unopened vials must be placed in the refrigerator (2°C–8°C).
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. How do I inject the dose of my insulin?
Wash your hands before injecting. Choose a site for injection. Clean the skin as instructed. Remove outer needle cap. Stabilize the skin by spreading it or pinching up a large area. Insert the needle as instructed. Press the knob. Pull the needle out and apply gentle pressure over the injection site for several seconds. Do not rub the area. Using the outer needle cap, unscrew the needle and dispose of it safely. Use of injection sites should be rotated so that the same site is not used more than approximately once a month.
Q. How to prepare my Eglucent Mix 25 Kwikpen 100IU/ml device before taking the injection?
The insulin device should be rotated in the palms of the hands ten times and inverted 180° ten times immediately before use to resuspend the insulin until it appears uniformly cloudy or milky. If not, repeat the above procedure until contents are mixed. Do not shake vigorously as this may cause frothing which may interfere with the correct measurement of the dose. The device/cartridge should be examined frequently and not be used if clumps of material are present or if solid white particles stick to the bottom or wall of the cartridge, giving a frosted appearance.
Q. Must I prime my pen before using it?
Yes, you need to prime your pen. If you do not prime, you may get too much or too little insulin. For priming, turn the dose knob to 2 units. Hold your pen with the needle pointing up. Tap the cartridge holder gently to collect air bubbles at the top. Continue holding your pen with the needle pointing up. Push the dose knob in until it stops and "0" is seen in the dose window. Hold the dose knob in and count to 5 slowly. You should see insulin at the tip of the needle.
Q. What should I do if the dose knob of the pen is hard to push?
Pushing the dose knob of the pen more slowly will make it easier to inject. Your needle may be blocked. Put on a new needle and prime the pen.
Q. What are the potential side effects of Eglucent Mix 25 Kwikpen 100IU/ml?
Low blood sugar (hypoglycemia) is the most common side effect. This may be associated with listlessness, confusion, palpitations, headache, sweating, and vomiting. Always carry a quick source of sugar such as glucose tablets, hard candy or juice to treat low blood sugar. Use of insulin is contraindicated during the episodes of hypoglycemia. Other possible side effects include severe life-threatening allergic reactions and reactions at the injection site.
Q. What should I do if I am experiencing any side effects?
If you are experiencing any side effects, please contact your doctor.
Q. Which drugs can increase the insulin requirement of a patient?
Insulin requirements may be increased by medications with hyperglycemic activity (medicines that increase glucose levels) such as corticosteroids, isoniazid, certain lipid-lowering drugs (e.g., niacin), estrogens, oral contraceptives, phenothiazines, and thyroid replacement therapy.
Q. Which drugs can decrease the insulin requirement of a patient?
Insulin requirements may be decreased in the presence of drugs that increase insulin sensitivity or have hypoglycemic (glucose lowering) activity, such as oral antidiabetic agents, salicylates, sulfa antibiotics, certain antidepressants (monoamine oxidase inhibitors), angiotensin-converting-enzyme inhibitors, angiotensin II receptor blocking agents, beta-adrenergic blockers, inhibitors of pancreatic function (e.g., octreotide), and alcohol. Beta-adrenergic blockers may mask the symptoms of hypoglycemia in some patients.
Q. Is it safe to use Eglucent Mix 25 Kwikpen 100IU/ml during pregnancy and lactation (breastfeeding)?
Data on a large number of exposed pregnancies do not indicate any adverse effect of insulin lispro (main constituent of Eglucent Mix 25 Kwikpen 100IU/ml) on pregnancy or on the health of the fetus/newborn. Insulin requirements usually fall during the first trimester and increase during the second and third trimesters. Patients with diabetes should inform their doctor, if they are pregnant or are contemplating the pregnancy. Careful monitoring of glucose control, as well as general health, is essential in pregnant patients with diabetes. Patients with diabetes who are breastfeeding may require adjustments in insulin dose, diet or both.
