Emvoid Injection

Mechanism Of Action

EMVOID I.V INJECTION is an antiemetic medicine. It works by blocking the transmission of nerve signals between the vomiting centres and the brain. This controls the onset of vomiting among patients who undergo chemotherapy.

Pharmacokinets

The mean absolute oral bioavailability of aprepitant is approximately 60 to 65%. Protein binding is reported to be >95%. Aprepitant primarily undergoes CYP3A4-mediated metabolism, as well as minor metabolism mediated by CYP1A2 and CYP2C19.

Side Effects

COMMON

Constipation, indigestion

Headache, tiredness

Loss of appetite

Hiccups

Liver problems

UNCOMMON

Dizziness, sleepiness

Acne, skin rash, skin redness, hot flushes

Anxiety

Burping, nausea, vomiting

Heartburn, stomach pain, dry mouth, flatulence

Pain or burning sensation while passing urine

Weakness

Faster or irregular heartbeats

High blood pressure

Fever with increased risk of infection

Low RBC count in blood

Injection site reactions (pain, redness, itching and inflammation)

RARE

Difficulty in thinking

Taste disturbance

Skin sensitivity, excessive sweating, sores on skin

Euphoria (feeling of extreme happiness), disorientation

Bacterial infection, fungal infection

Stomach ulcer, inflammation of the small intestine and colon, oral sores, bloating

Increased or frequent urination

Presence of sugar or blood in urine

Cough with mucus, throat irritation

Sneezing, excessive thirst

Eye discharge and itching, ringing in the ear

Muscle spasms

Slow heartbeat

Low WBC in blood

Low blood sodium levels

Weight loss

Contra Indications

Few contraindications exist to the use of aprepitant or fosaprepitant.[30][31]

Commonly cited contraindications include prior hypersensitivity reactions and the coadministration of pimozide or cisapride. ...

Aprepitant is a weak CYP3A4 inhibitor.

Pregnancy Related Information

EMVOID I.V INJECTION should not be used in pregnant women unless considered necessary by the physician. Therefore, inform your doctor if you are pregnant or think you may be pregnant before receiving EMVOID I.V INJECTION. Women of childbearing age must consult their doctor for a suitable birth control method to avoid pregnancy while undergoing therapy with this medicine.

Product And Alcohol Interaction

Avoid consumption of alcohol before receiving EMVOID I.V INJECTION.

Breast Feeding Related Information

It is not whether EMVOID I.V INJECTION is excreted through breast milk. Therefore, it is not recommended for use in breastfeeding women. Consult your doctor for advice.

Indications

Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy.

Interactions

Drug-Drug Interactions: Avoid taking APREPITANT with antipsychotics (pimozide), antiallergic drugs (terfenadine, astemizole), and gastroprokinetic agents (cisapride). APREPITANT may interact with immunosuppressants (tacrolimus, everolimus, cyclosporine, sirolimus), pain killers (fentanyl, alfentanil), the medicine used to treat an irregular heartbeat (quinidine), anticancer medicines (etoposide, vinorelbine, irinotecan, ifosfamide), blood thinners (acenocoumarol, warfarin), antibiotics (clarithromycin, telithromycin, rifampicin), anticonvulsants (phenytoin, carbamazepine), medicines used to produce calmness or help you sleep (triazolam, phenobarbital, midazolam), antifungals (ketoconazole, voriconazole, posaconazole, itraconazole), antidepressant (nefazodone), corticosteroids (dexamethasone, methylprednisolone), anti-anxiety medicines (alprazolam), antidiabetic agent (tolbutamide) and medicines used to treat migraines and HIV infections.

Drug-Food Interactions: APREPITANT may interact with St. John’s Wort (herbal preparation used to treat depression).

Drug-Disease Interactions: If you have liver disease, inform your doctor before taking APREPITANT.

Drug-Drug Interactions Checker List:

PIMOZIDE

TERFENADINE

ASTEMIZOLE

CISAPRIDE

TACROLIMUS

EVEROLIMUS

CYCLOSPORINE

SIROLIMUS

FENTANYL

ALFENTANIL

QUINIDINE

ETOPOSIDE

IRINOTECAN

ifosfamide

ACENOCOUMAROL

WARFARIN

CLARITHROMYCIN

TELITHROMYCIN

RIFAMPICIN

PHENYTOIN

CARBAMAZEPINE

TRIAZOLAM

PHENOBARBITAL

MIDAZOLAM

KETOCONAZOLE

VORICONAZOLE

POSACONAZOLE

ITRACONAZOLE

NEFAZODONE

DEXAMETHASONE

METHYLPREDNISOLONE

ALPRAZOLAM

TOLBUTAMIDE

Storage Requirements

Keep EMVOID I.V INJECTION out of reach of children

Store EMVOID I.V INJECTION in a refrigerator between 2-8°C

Effects Of Missed Dosage

 contact your doctor 

Effects Of Overdose

EMVOID I.V INJECTION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. However, contact your doctor if you experience any unusual side effects.

How To Use

EMVOID I.V INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously). Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

FAQs

Q: Is EMVOID I.V INJECTION a chemo drug?

A: No. EMVOID I.V INJECTION is an antiemetic medicine used to manage nausea and vomiting caused due to chemotherapy.

Q: What class does EMVOID I.V INJECTION belongs to?

A: EMVOID I.V INJECTION belongs to NK1 receptor antagonists which works by blocking the transmission of nerve signals between brain and vomiting centers, thereby reducing vomiting caused by chemotherapy.

Q: Is foraprepitant same as aprepitant?

A: Fosaprepitant is a prodrug of aprepitant. Following administration, fosaprepitant gets converted into the body as aprepitant and exerts its effects.