This medicine works by reducing the action of certain chemicals that cause swelling and pain in the body.
Oral bioavailability averaged 96%. Absorption was rapid, achieving maximum hydrocortisone levels of 300 ng/mL after 1 hour. Saliva levels were not proportional to plasma levels, but could be shown to reflect free, non-protein bound hydrocortisone concentrations in plasma.
Major & minor side effects for Entofoam Rectal Foam
Anal irritation
Swelling of eyelids, face, lips, tongue
Skin discoloration
Contraindications Hydrocortisone is contraindicated in patients with a history of hypersensitivity to the product or any of its constituent ingredients, patients with tuberculosis or fungal infection and/or herpes infections of the eyes, lips, or genitals.
This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before using this medicine.
This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before using this medicine.
Hydrocortisone is used to treat certain medical conditions, such as inflammation (swelling), severe allergic reactions, kidney diseases, adrenal problems, arthritis, blood or bone marrow problems, eye or vision problems, lung or breathing problems (eg, asthma), lupus, skin conditions, and ulcerative colitis.
Drug-Drug Interactions: Inform your doctor if you are taking antidiabetic drugs (insulin), non-steroidal anti-inflammatory drugs (aspirin, ibuprofen, diclofenac, naproxen), blood thinners (warfarin), cardiac glycosides (digoxin), diuretics (water tablets), medicines used to treat glaucoma (acetazolamide), central nervous system stimulant (ephedrine), antituberculosis drugs (rifabutin, rifampicin), anticonvulsants (phenobarbital, phenytoin, carbamazepine, primidone), growth hormone (somatropin), oral contraceptive, anti-progesterone (mifepristone), antifungal (amphotericin B, ketoconazole), antibiotic (erythromycin), anti-asthma drug (theophylline), an ulcer healing drug (carbenoxolone) and anti-HIV drugs (ritonavir).
Drug-Food Interactions: HYDROCORTISONE may interact with St. John's wort (an antidepressant herbal supplement).
Drug-Disease Interaction: Avoid taking HYDROCORTISONE if you have candida, thrush, or other infection. If you have ever had severe depression or bipolar disorder, tuberculosis (TB), glaucoma (increased pressure in the eye), have recently had a heart attack or high blood pressure, fits, osteoporosis (thinning of bones), diabetes, thyroid problems, weakened immune system, stomach ulcers, liver, kidney or heart problems, infection, inform your doctor before taking HYDROCORTISONE.
Drug-Drug Interactions Checker List:
INSULIN HUMAN
ASPIRIN
IBUPROFEN
DICLOFENAC
NAPROXEN
WARFARIN
DIGOXIN
ACETAZOLAMIDE
EPHEDRINE
RIFABUTIN
RIFAMPICIN
PHENOBARBITAL
PHENYTOIN
CARBAMAZEPINE
PRIMIDONE
SOMATROPIN
MIFEPRISTONE
AMPHOTERICIN B
KETOCONAZOLE
ERYTHROMYCIN
THEOPHYLLINE
CARBENOXOLONE
RITONAVIR
Store below 30°C
Use the missed dose as soon as you remember. The missed dose can be skipped if it is almost the time for the next scheduled dose.
Seek emergency medical treatment or contact the doctor in case of an overdose.
Ulcerative proctitis
This medicine is used as adjuvant therapy in the topical treatment of ulcerative proctitis of the rectum (inflammatory bowel disease that is characterized by swelling, redness, and ulcerations in the inner mucosal lining of the rectum) in patients with ulcerative colitis (an inflammatory bowel disease).
Proctosigmoiditis
This medicine is used in the topical treatment of proctosigmoiditis (inflammation of the rectum and sigmoid colon).
