Manufacturer: Lupin Ltd
Salt Composition : Salmeterol(25mcg), Fluticasone Propionate(250mcg)
Your doctor will tell you how often you need to use your inhaler. The effect of this medicine may be noticeable after a few days but will only reach its maximum after a few weeks. This medicine must be used regularly to be effective, so go on taking it even if you don't have any symptoms. That means it’s doing its job. If you stop taking it your asthma and chronic obstructive pulmonary disorder (COPD) may get worse. It should not be used to relieve sudden asthma attacks. If an asthma attack occurs, use your quick-relief inhaler (reliever). To get the benefit from this medicine you need to make sure you get your inhaler technique right, otherwise, it does not work as well.
The most common side effects are nausea, vomiting, respiratory tract infection, fungal infections in the mouth, headache, hoarseness of voice, sore throat, cough, musculoskeletal (bone, muscle, or joint) pain, and increased heart rate. If you get there, do not stop taking it but do talk to your doctor. You can help prevent some of these symptoms by rinsing your mouth and throat with water or brushing your teeth after using your inhaler. There are other, rarer side effects that can be serious. Talk to your doctor if you're worried about them. In general, you should be trying to avoid situations that make your asthma worse (your triggers) and try not to smoke.
Esiflo 250 Transhaler is a combination of two medicines: Salmeterol and Fluticasone Propionate. Salmeterol is a long-acting bronchodilator which works by relaxing the muscles in the airways and widens the airways. Fluticasone Propionate is a steroid. It works by stopping the release of certain chemical messengers that cause inflammation (swelling) of the airways. Together, they make breathing easier.
Salmeterol is an inhaled long-acting selective beta(2)-adrenoceptor agonist that is commercially available as the xinafoate (1-hydroxy-2-naphthoic acid) salt of the racemic mixture of the two optical isomers, (R)- and (S)-, of salmeterol. It acts locally in the lung through action on beta2 receptors.Fluticasone binds and activates glucocorticoid receptor, resulting in the activation of lipocortin. Lipocortin, in turn, inhibits cytosolic phospholipase A2, which triggers a cascade of reactions involved in the synthesis of inflammatory mediators, such as prostaglandins and leukotrienes.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Esiflo
Nausea
Vomiting
Respiratory tract infection
Fungal infection of mouth
Sore throat
Headache
Hoarseness of voice
Cough
Musculoskeletal (bone, muscle or joint) pain
Increased heart rate
If you are suffering from any of the following diseases, you should not take Fluticasone + Salmeterol unless your doctor advises you to do so -
Diabetes
Glaucoma
Allergy
Infections
Osteoporosis
Liver Disease
Cataract
Malnutrition
Cushing's Syndrome
Drug Allergy
Asthma
Heart Disease
Diabetes
Glaucoma
Hyperthyroidism
Liver Disease
Thyroid
Esiflo 250 Transhaler may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Esiflo 250 Transhaler. Please consult your doctor.
Esiflo 250 Transhaler is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Use with caution
Below 9years: Contraindicated
Inhaled fluticasone and salmeterol is used to prevent asthma attacks and to treat chronic obstructive pulmonary disease (COPD). It is not used to relieve an asthma attack that has already started. For relief of an asthma attack that has already started, you should use another medicine.
FLUTICASONE PROPIONATE+SALMETEROL may interact with bronchodilators (salbutamol, aminophylline, theophylline), steroids (budesonide, prednisone, mometasone, beclomethasone), heart-related medicines (sotalol, digoxin, disopyramide, procainamide, quinidine), drugs used to treat Hodgkin’s disease (procarbazine), water pills (furosemide), antibiotics (telithromycin, furazolidone, clarithromycin), drugs used to lower high blood pressure (atenolol, metoprolol, propranolol), medicines to induce labour (oxytocin), antithyroid agent (levothyroxine), antidepressants (imipramine, amitriptyline, isocarboxazid, phenelzine), antifungals (itraconazole, ketoconazole), HIV medicines (atazanavir, ritonavir, nelfinavir, indinavir, cobicistat, saquinavir) and antiparkinson drug (levodopa).
Shake the inhaler. While you are breathing in from mouth, press down on the inhaler one time to release the medication and hold your breath for 10 seconds. Repeat until you have inhaled the number of puffs as suggested by the doctor.Afterwards, rinse your mouth thoroughly with water and spit it out.
Store below 30°C
If you miss a dose of Esiflo 250 Transhaler, use it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
This medicine is for inhalation only. The tablet should not be swallowed.
It should be taken at the same time each day.
It does not work right away and should not be used to relieve sudden breathing problems. Use your rescue inhaler to control sudden difficulty in breathing.
Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake and sugarless candy may help.
Gargle with warm water after each inhalation to avoid any fungal infections in your mouth and throat.
Take the first dose of this medicine under medical supervision as it may cause wheezing or tightening of the airways (bronchospasm) immediately after using.
Your doctor may regularly monitor your blood potassium level as low oxygen level in the blood (hypoxia) and medicines such as Esiflo 250 Transhaler can lower blood potassium level.
Only miniscule amounts of Esiflo 250 Transhaler may get absorbed into the bloodstream after inhalation. Hence, serious side effects are unlikely.
Check the label for directions before use. Shake the inhaler. While you are breathing in from mouth, press down on the inhaler one time to release the medication and hold your breath for 10 seconds. Repeat until you have inhaled the number of puffs as suggested by the doctor.Afterwards, rinse your mouth thoroughly with water and spit it out.
Q. What is Esiflo 250 Transhaler prescribed for?
Esiflo 250 Transhaler is prescribed to treat Chronic Obstructive Pulmonary Disease and Asthma. The symptoms may include wheezing, shortness of breath, and breathing difficulties.
Q. Can I stop taking Esiflo 250 Transhaler when my symptoms are relieved?
No, do not stop taking Esiflo 250 Transhaler. If you stop taking Esiflo 250 Transhaler, your symptoms may come back and may lead to serious complications. Take your medicine as advised by your doctor.
Q. Will Esiflo 250 Transhaler be more effective if taken in more than recommended dose?
No, taking more of this medicine will not make it more effective, rather it can lead to increased side effects. If symptoms are not getting relieved by the recommended doses, please consult the doctor for re-evaluation.
Q. What are the instructions for storage and disposal of Esiflo 250 Transhaler?
Keep this medicine in the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
