Manufacturer: Alkem Laboratories Ltd
Salt Composition : Calcitriol(0.25mcg), Calcium Carbonate(500mg), Zinc(7.5mg), Risedronate(35mg)
Gemcal -Kit is best taken in an empty stomach. You should take it regularly at a fixed time each day. Taking it at the same time every day will help you remember to take it. It may take several days to get the full benefit of this drug. Do not stop taking the medicine until your doctor tells you it is alright to stop. This medicine may only be part of a treatment program that may also include changes to your diet and taking other medicines and vitamin supplements.
The most common side effects of this medicine include headache, back pain, musculoskeletal (bone, muscle or joint) pain, indigestion, heartburn, and diarrhea. These are generally mild and usually resolve on their own. If they do not go away or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the side effects.
Before using this medicine, let your doctor know if you have any medical conditions or disorders. To make sure the medicine is safe for you, let your doctor also know all the other medicines you are taking. You may need frequent medical tests to check your kidney function and mineral levels while on treatment with this medicine. You should avoid consuming large amounts of alcohol, as it can cause bone loss. Pregnant and breastfeeding mothers should consult their doctors before using this medicine.
Gemcal -Kit is a combination of four medicines: Calcitriol, Calcium Carbonate, Zinc and Risedronate which treat osteoporosis. Calcitriol is a form of vitamin D which helps your body effectively absorb Calcium Carbonate and additionally supports the muscles needed to avoid falls. Calcium Carbonate and Zinc are minerals which help build and maintain bones. Risedronate is a bisphosphonate which works by suppressing the activity of osteoclasts, cells that cause destruction of bone. This strengthens the bone and minimizes the risk of fractures.
Following administration of single doses of 0.25 to 1.0 mcg of calcitriol, the peak plasma concentrations were reached within 3 to 6 hours Label. In a pharmacokinetic study, the oral bioavailability was 70.6±5.8% in healthy male volunteers and 72.2±4.8% in male patients with uraemia 8.calcium carbonate acts by directly increasing calcium stores within the body. Calcium carbonate is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. It also inhibits the action of pepsin by increasing the pH and via adsorption.Zinc can treat acute and chronic diarrhea by inhibiting three out of the four main intracellular pathways of intestinal ion secretion, including cyclic adenosine monophosphate (cAMP), calcium, and nitric oxide.The absolute bioavailability of orally administered risedronate is approximately 0.6%, and is independent of formulation. Variability in the pharmacokinetics following oral administration is primarily associated with intrasubject variability in absorption.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Gemcal
Headache
Increased calcium level in blood
Abdominal pain
Nausea
Rash
Urinary tract infection
Kidney Disease
Hypercalcemia
Arrhythmia
Kidney Disease
Heart Disease
Drug Allergy
Kidney Disease
Gemcal -Kit may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is unsafe to consume alcohol with Gemcal -Kit.
Gemcal -Kit is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Use with caution
Below 9years: Contraindicated
Calcitriol+Calcium Carbonate+Zinc+Risedronate is used in the treatment of osteoporosis.Calcitriol is a form of vitamin D which helps your body effectively absorb Calcium Carbonate and additionally supports the muscles needed to avoid falls. Calcium Carbonate and Zinc are minerals which help build and maintain bones. Risedronate is a bisphosphonate which works by suppressing the activity of osteoclasts, cells that cause destruction of bone. This strengthens the bone and minimizes the risk of fractures.
Anti-cancer medication (estramustine), Cholestyramine (cholesterol-lowering agent), Digitalis (used to treat heart problems), medicines to treat bacterial infections such as Ciprofloxacin, Levofloxacin, Gatifloxacin, Sparfloxacin, Ofloxacin; Ketoconazole (treat fungal infections).
Do not chew, crush or break it. Gemcal -Kit is to be taken empty stomach.
Store below 30°C
If you miss a dose of Gemcal -Kit, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Gemcal -Kit is prescribed for the treatment of osteoporosis.
Drink plenty of water while taking this medicine.
For at least 30 minutes after taking Gemcal -Kit:
Do not lie down or recline.
Do not take any other medicine including vitamins, calcium, iron, antacids, or laxatives.
Along with taking Gemcal -Kit, maintain a healthy lifestyle, take a balanced diet, exercise (regular weight-bearing exercise) with your doctor's advise and take proper measures to reduce the risk of falls.
Let your doctor know if you’re taking an iron supplement, as the absorption rate might be affected.
Inform your doctor if you have kidney problems, or if you have ever had kidney stones.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Gemcal -Kit is to be taken empty stomach.
