Manufacturer: Gland Pharma Limited
Salt Composition : Capecitabine(500mg)
GLANCAP 500MG TABLET is not recommended for use if you have severe liver or kidney disease. GLANCAP 500MG TABLET should be used with caution in patients with liver disease, kidney disease, heart problems, brain disease or nerve damage, diabetes, or a history of eye problems. Consult your doctor before taking this medicine.
GLANCAP 500MG TABLET is not recommended for use by pregnant or breastfeeding women. Consult your doctor before taking this medicine.
GLANCAP 500MG TABLET is not recommended for use by children and adolescents. Consult your doctor before taking this medicine.
The most common side effects of taking GLANCAP 500MG TABLET are abdominal pain, rash, dry or itchy skin, tiredness, and loss of appetite. Consult your doctor if any of these symptoms worsen.
GLANCAP 500MG TABLET is an antimetabolite that works by stopping the abnormal growth of cells. Thus, it helps manage the conditions associated with it.
Metabolism and General Pharmacokinetics. After oral administration with food, capecitabine is rapidly and extensively absorbed unchanged from the GI tract, and is sequentially converted to the cytotoxic moiety, fluorouracil, in a series of metabolic steps.
COMMON
Abdominal pain
Rash, dry, or itchy skin
Tiredness
Loss of appetite
Dehydration and weight loss
Sleeplessness (insomnia), depression
Headache, sleepiness, and dizziness
Tingling sensations or numbness in the skin
Changes in taste
Increased tears, irritation in the eye, and redness of the eyes (conjunctivitis)
Inflammation of the veins (thrombophlebitis)
Shortness of breath, bleeding from the nose, cough, or runny nose
Cold sores or other herpes infections
Infections of the lungs or respiratory system (pneumonia or bronchitis)
Bleeding from the gut, constipation, pain in the upper abdomen, indigestion, excess wind
Dry mouth
Skin problems (rash, reddening, dry skin, itching, skin discoloration, skin loss)
Inflammation, nail disorder, hair loss (alopecia)
Painful joints or limbs (hands and legs), chest, or back
Fever, swelling in the limbs, feeling ill
Nerve pain
Ringing or buzzing in the ears (tinnitus), loss of hearing
Hiccups, change in voice
Pain or altered or abnormal sensation in the mouth; pain in the jaw; sweating; night sweats
Muscle spasm
Difficulty in urinating, blood, or protein in the urine
Bruising or reaction at the injection site
UNCOMMON
Blood infection, urinary tract infection, infection of the skin, infections in the nose and throat, fungal infections (including those of the mouth), influenza, gastroenteritis, tooth abscess
Lumps under the skin (lipoma)
Allergy
Diabetes
Malnutrition
Confusional state, panic attacks, and a depressed mood
Decreased libido
Difficulty speaking
Impaired memory
Loss of movement coordination, balance problems
Fainting
Nerve damage and altered sensation
Blurred or double vision
Vertigo, pain in the ear
Irregular and fast heartbeat (arrhythmias), chest pain, and heart attack
Blood clots in the deep veins
High or low blood pressure
Hot flushes
Cold limbs (hands or feet)
Purple spots on the skin
Respiratory problems such as blood clots in the veins in the lung (pulmonary embolism), collapsed lungs, coughing up blood, asthma, and shortness of breath on exertion
Gastrointestinal problems (bowel obstruction, collection of fluid in the abdomen, inflammation of the small or large intestine, the stomach, or the oesophagus, pain in the lower abdomen, abdominal discomfort, heartburn, blood in the stool)
Jaundice (yellowing of the skin and eyes)
Ulcer and blister on skin, skin reaction with sunlight, reddening of palms, swelling or pain of the face
Joint swelling or stiffness of joints, bone pain, weakness, or stiffness of muscles
Fluid collection in the kidneys, an increase in the frequency of urination during the night, and incontinence (loss of bladder control)
Unusual bleeding from the vagina
Swelling (oedema)
Chills and rigors
RARE
Narrowing or blockage of the tear duct (lacrimal duct stenosis)
Liver failure, inflammation leading to dysfunction or obstruction in bile secretion (cholestatic hepatitis)
Specific changes in the electrocardiogram (QT prolongation)
Certain types of arrhythmias (including ventricular fibrillation, torsade de pointes, and bradycardia)
Eye inflammation causing eye pain and possibly eyesight problems
Inflammation of the skin causing red, scaly patches due to an immune system illness
Stop taking GLANCAP 500MG TABLET and contact your doctor immediately if you experience any of the following side effects:
Diarrhoea
Nausea and vomiting
Stomatitis (redness, pain, swelling, or sores in the mouth or throat)
Hand-and-foot skin reaction (pain, swelling, redness, or tingling of hands and/or feet)
Fever
Infection
Chest pain
Steven Johnson syndrome (painful red or purplish rash that spreads and blisters or other lesions begin to appear in the mouth and lips), especially if you had before light sensitivity, infections of the respiratory system (Ex. bronchitis), and/or fever
Angioedema (swelling of the lips, face, throat, or tongue causing difficulty swallowing or breathing, itchiness, and rashes)
May result in bleeding, death; monitor anticoagulant response (INR) and adjust anticoagulant dose accordingly.
Diarrhea may be severe; interrupt capecitabine treatment immediately until diarrhea resolves or decreases to grade 1; recommend standard antidiarrheal treatments.
GLANCAP 500MG TABLET is not recommended for use by pregnant women. Women of childbearing potential should use effective contraception during management with GLANCAP 500MG TABLET and for 6 months after the last dose.
If you are a male patient and your female partner could become pregnant, you should use effective contraception during management with GLANCAP 500MG TABLET and for 3 months after the last dose. Consult your doctor before taking GLANCAP 500MG TABLET.
GLANCAP 500MG TABLET is not recommended for use in breastfeeding women, and do not breastfeed for 2 weeks after the last dose of GLANCAP 500MG TABLET. Consult your doctor before taking it.
Capecitabine tablets are indicated for the: treatment of adults with unresectable or metastatic gastric, esophageal, or gastroesophageal junction cancer as a component of a combination chemotherapy regimen.
Drug-Drug Interactions: CAPECITABINE interacts with other anti-cancer medicines (folinic acid, oxaliplatin, bevacizumab, cisplatin, irinotecan), antibiotics (metronidazole), medicines used to reduce the harmful effects of anti-cancer medicines (calcium leucovorin), a medicine used to treat gout (allopurinol), a medicine used to treat stomach ulcers (cimetidine), blood thinners (warfarin, coumarin), antivirals (brivudine, sorivudine), and anti-epilepsy medicine (phenytoin).
Drug-Food Interactions: CAPECITABINE is known to interact with alcohol and increase dizziness.
Drug-Disease Interactions: CAPECITABINE should not be given to patients with liver, heart or kidney problems, diabetes, glaucoma (increased eye pressure), myelosuppression (bone marrow activity is decreased), dihydropyrimidine dehydrogenase (DPD) enzyme deficiency, stomatitis, infections, or a bleeding disorder.
Drug-Drug Interactions Checker List:
BEVACIZUMAB
CISPLATIN
METRONIDAZOLE
CALCIUM LEUCOVORIN
ALLOPURINOL
CIMETIDINE
WARFARIN
COUMARINS
BRIVUDINE
SORIVUDINE
PHENYTOIN
Keep GLANCAP 500MG TABLET out of reach of children
Store below 30°C
consult your doctor
If you or anyone else accidentally takes too much of GLANCAP 500MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are nausea, vomiting, diarrhea, inflammation or ulceration of the gut or mouth, pain or bleeding from the intestine or stomach, or bone marrow depression (reduction in certain kinds of blood cells).
GLANCAP 500MG TABLET is not recommended for use in children and adolescents. Consult your doctor before taking GLANCAP 500MG TABLET.
Q: What should I inform my doctor before starting with GLANCAP 500MG TABLET?
A: Before starting the management with GLANCAP 500MG TABLET, you should inform your doctor if you have kidney, liver, or heart disease, diarrhea, dehydration, nausea and vomiting, brain disease (Ex. cancer that has spread to the brain or nerve damage (neuropathy), diabetes, a history of eye problems, or severe skin reactions.
Q: What if I forget to take a dose of GLANCAP 500MG TABLET?
A: If you have missed a dose, take it as soon as you remember it. Do not take a double dose to compensate for the missed dose of GLANCAP 500MG TABLET. Continue taking the medicine as per your schedule. Talk to your doctor.
Q: Is GLANCAP 500MG TABLET a form of chemotherapy?
A: Yes. GLANCAP 500MG TABLET is an oral chemotherapy medicine that is used in the management of abnormal growth of cells present in the colon, rectal, gastric, and breast regions. Your doctor will decide the correct management plan for you.
Q: How long do I have to take GLANCAP 500MG TABLET?
A: Your doctor will decide the correct dose of GLANCAP 500MG TABLET and number of cycles for you depending upon your body weight, age, and disease condition. GLANCAP 500MG TABLET are usually taken for 14 days, followed by a 7-day rest period. This 21-day period is one management cycle. In some cases, you will advise taking GLANCAP 500MG TABLET every day while using it in combination with other medicines.
Q: Can I stop taking GLANCAP 500MG TABLET if I feel better?
A: No. You should not stop taking GLANCAP 500MG TABLET or change the dose until and unless your doctor asks you to. You will be at high risk of getting back the symptoms and dangerous tumour growth. Talk to your doctor.
Q: Can GLANCAP 500MG TABLET cause eye problems?
A: Prior to starting management with GLANCAP 500MG TABLET, you should inform your doctor if you have a history of eye problems. While you are managing with GLANCAP 500MG TABLET, you may need monitoring of your eyes. Talk to your doctor before taking GLANCAP 500MG TABLET.
Q: Does GLANCAP 500MG TABLET shrink tumours?
A: No, GLANCAP 500MG TABLET does not shrink tumours. GLANCAP 500MG TABLET contains capecitabine, which works by stopping or reducing the abnormal growth of cells, which is called cytostatic activity. Only after being absorbed by the body is it changed into an active anti-neoplastic medicine (more in tumour tissue than in normal tissue). Therefore, it stops tumour growth and spreading without causing them to shrink.
Q: Does GLANCAP 500MG TABLET cause hair loss?
A: Yes, the most common side effect of GLANCAP 500MG TABLET is hair loss. Before your management, prepare in advance for changes in your hair. Talk to your doctor about what to expect. Use head coverings such as a wig or scarf. Try to add iron and protein-rich foods like green leafy vegetables and beans to snacks and meals.
Q: Can I take double doses together to cure my condition soon?
A: No, do not take more GLANCAP 500MG TABLET than the normal recommended dose as it may cause overdosage of GLANCAP 500MG TABLET, leading to harmful side effects such as diarrhea, inflammation of the gut or mouth, pain or bleeding in the stomach or bone marrow, depression (reduction in blood cells), nausea, and vomiting.
