Manufacturer: Lancer Health Care Pvt Ltd
Salt Composition : Gliclazide(80mg), Metformin(500mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Glicab MF 80mg/500mg Tablet should be taken with food. Take it regularly at the same time each day to get the most benefit. Your doctor will decide what dose is best for you and this may change from time to time according to how it is working according to your blood sugar levels.
Keep taking this medicine, even if you feel well or your blood sugar levels are controlled. If you stop it without consulting your doctor, your blood sugar levels could rise and put you at risk of kidney damage, blindness, nerve problems and loss of limbs. Remember that it is only part of a treatment program that should also include a healthy diet, regular exercise, and weight reduction as advised by your doctor. Your lifestyle plays a big part in controlling diabetes.
The most common side effect of Glicab MF 80mg/500mg Tablet is low blood glucose levels (hypoglycemia). Make sure you recognize the signs of having low blood glucose levels, such as sweating, dizziness, headache, and shaking and know how to deal with it. To prevent this, it's important to have regular meals and always carry a fast-acting source of glucose such as sugary food or fruit juice with you. Drinking alcohol can also increase your risk of low blood sugar levels and should be avoided. Other side effects that may be seen on taking this medicine include taste changes, nausea, diarrhea, stomach pain, headache, and upper respiratory tract infection. Some people may find that they put on weight with this medicine.
Gliclazide stimulates insulin secretion through the beta cell sulphonylurea receptor, and possibly through a direct effect on intracellular calcium transport. It specifically improves the abnormal first phase insulin release in type 2 diabetes, and also has an effect on the second phase.
The centre of metformin's mechanism of action is the alteration of the energy metabolism of the cell. Metformin exerts its prevailing, glucose-lowering effect by inhibiting hepatic gluconeogenesis and opposing the action of glucagon.
A single oral dose of 40 to 120 mg of gliclazide results in a Cmax of 2.2 to 8.0 µg/ml within 2 to 8 hours. Tmax and cmax are increased after repeated gliclazide administration. Steady state concentration is achieved after 2 days administration of 40 to 120 mg of gliclazide.Metformin is rapidly distributed following absorption and does not bind to plasma proteins. No metabolites or conjugates of metformin have been identified. The absence of liver metabolism clearly differentiates the pharmacokinetics of metformin from that of other biguanides, such as phenformin.
Hypoglycemia (low blood glucose level)
Headache
Nausea
Dizziness
Diarrhea
Flatulence
If you are allergic to gliclazide, metformin or similar medicines
If you have uncontrolled diabetes along with nausea, vomiting, diarrhoea, weight loss, stomach pain, etc
If you have diabetic pre-coma
If you have problems with your heart, liver or kidneys
If you have any severe infection
If you have a hereditary disease - porphyria
If you are suffering from dehydration
If you are taking a medicine called miconazole to treat fungal infections
If you consume alcohol in excess
If you are a breastfeeding mother
Glicab MF 80mg/500mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is unsafe to consume alcohol with Glicab MF 80mg/500mg Tablet.
Glicab MF 80mg/500mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Gliclazide + Metformin is a combination of two antidiabetic medicines: Gliclazide and Metformin. Gliclazide is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide which works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin.
GLICLAZIDE+METFORMIN may interact with insulin, high blood pressure-lowering pills (e.g. hydrochlorothiazide, amlodipine), water pills/diuretics (e.g. furosemide), heart failure-related medicines (e.g. digoxin), anti-hypertensive (e.g. metoprolol), steroids (e.g. prednisolone), thyroid hormones etc. So, tell your doctor if you are using these drugs before taking the GLICLAZIDE+METFORMIN.
Do not chew, crush or break it. Glicab MF 80mg/500mg Tablet is to be taken with food.
Store below 30°C
If you miss a dose of Glicab MF 80mg/500mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Monitor your blood sugar level regularly while you are taking this medicine.
It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic.
Tell your doctor immediately if you experience any deep or rapid breathing or if you have persistent nausea, vomiting, and stomach pain as Glicab MF 80mg/500mg Tablet may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Glicab MF 80mg/500mg Tablet is to be taken with food.
Q. What is Glicab MF 80mg/500mg Tablet?
Glicab MF 80mg/500mg Tablet is a combination of two medicines: Gliclazide and Metformin. This medicine is used in the treatment of type 2 diabetes mellitus (DM). It improves blood glucose levels in adults when taken along with proper diet and regular exercise. Gliclazide lowers the blood glucose levels by increasing the release of insulin from the pancreas. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. This combination is not indicated for the treatment of Type 1 DM.
Q. What are the possible side effects of Glicab MF 80mg/500mg Tablet?
The use of Glicab MF 80mg/500mg Tablet is associated with common side effects. These side effects may include hypoglycemia (low blood sugar level), altered taste, nausea, stomach pain, diarrhea, headache and upper respiratory tract infection. Its use can also lead to serious but rare side effects like lactic acidosis. On long-term use, it can also lead to vitamin B12 deficiency.
Q. Can the use of Glicab MF 80mg/500mg Tablet cause hypoglycemia?
Yes, the use of Glicab MF 80mg/500mg Tablet can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate and feeling anxious or shaky. It happens more often if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, regular monitoring of blood sugar level is important. Always keep glucose tablets, honey or fruit juice with you.
Q. Can the use of Glicab MF 80mg/500mg Tablet cause lactic acidosis?
Yes, the use of Glicab MF 80mg/500mg Tablet can lead to lactic acidosis. It is a medical emergency which is caused by increased levels of lactic acid in the blood. It is also known as MALA (Metformin associated lactic acidosis). It is a rare side effect associated with the use of metformin. It is avoided in patients with underlying kidney disease, old age patients or who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, feeling of cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain or slow heart rate. If you have these symptoms, stop taking Glicab MF 80mg/500mg Tablet and immediately consult your doctor.
Q. Can the use of Glicab MF 80mg/500mg Tablet lead to Vitamin B12 deficiency?
Yes, the use of Glicab MF 80mg/500mg Tablet can cause vitamin B12 deficiency on long-term use. The deficiency occurs as the medicine interferes with absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient can have tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in maintaining balance (ataxia). To avoid such problems, some researchers suggest an intake of vitamin B12 from outside sources at least once every year.
Q. Are there any specific conditions in which Glicab MF 80mg/500mg Tablet should not to be taken?
The use of Glicab MF 80mg/500mg Tablet should be avoided in patients with known allergy to any of the component or excipients of this medicine. It is also avoided in patients with moderate to severe kidney disease or with underlying metabolic acidosis including diabetic ketoacidosis.
Q. Is it safe to take alcohol while I am also taking Glicab MF 80mg/500mg Tablet?
No, it is not safe to take alcohol along with Glicab MF 80mg/500mg Tablet. It may lower your low blood sugar levels (hypoglycemia) and can increase the chances of lactic acidosis.
