Manufacturer: Lupin Ltd
Salt Composition : Glimepiride(2mg), Metformin(500mg), Pioglitazone(15mg)
Strip of 15 Tablet Pr
(Inclusive of all taxes)
Gluconorm PG 2 Tablet PR should be taken in the dose and duration as advised by your doctor. It must be taken with food to avoid stomach upset. If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Overdose may lead to low blood sugar (hypoglycemia).
Some people may develop hypoglycemia (low blood sugar level) when this medicine is taken along with other antidiabetic medicines, alcohol or upon skipping a meal. Monitor your blood sugar levels regularly while taking it. Other common side effects of this medicine include nausea, taste changes, diarrhea, stomach pain, headache, edema (swelling), blurred vision, bone fracture, and respiratory tract infection.
Gluconorm PG 2 Tablet PR is a medicine that helps to control high blood glucose (sugar) levels. It helps get rid of extra glucose from your body through urine. It also improves the body’s response to the hormone insulin, which is responsible for regulating blood glucose (sugar) levels in our body. The insulin helps to lower your blood glucose levels and prevents them from rising after taking meals. You should keep taking it for as long as it is prescribed.
Glimepiride is reported to undergo hepatic metabolism. Following either an intravenous or oral dose, glimepiride undergoes oxidative biotransformation mediated by CYP2C9 enzyme to form a major metabolite, cyclohexyl hydroxymethyl derivative (M1), that is pharmacologically active.The drug is widely distributed into body tissues including the intestine, liver, and kidney by organic cation transporters [6]. There is a large interindividual variability in metformin pharmacokinetics as measured by differences in trough steady-state metformin plasma concentration ranging from 54 to 4133 ng/ml.Pioglitazone is a thiazolidinedione that increases insulin sensitivity in target tissues. It is well-absorbed, with a mean absolute bioavailability of 83% and reaching maximum concentrations in around 1.5 hours. It is metabolised by the hepatic cytochrome P450 enzyme system.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Gluconorm PG
Hypoglycemia (low blood glucose level)
Dizziness
Headache
Nausea
Vomiting
Diarrhea
Flatulence
Bronchitis (inflammation of the airways)
Anemia (low number of red blood cells)
Edema (swelling)
If you are suffering from any of the following diseases, you should not take Glimepiride + Metformin + Pioglitazone unless your doctor advises you to do so -
Liver Disease
Kidney Disease
Gluconorm PG 2 Tablet PR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is unsafe to consume alcohol with Gluconorm PG 2 Tablet PR.
Gluconorm PG 2 Tablet PR is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Use with caution
Below 9years: Contraindicated
GLIMEPIRIDE+METFORMIN+PIOGLITAZONE belongs to the group of medications called 'antidiabetic agents' used in the treatment of Type 2 diabetes mellitus. Type 2 diabetes mellitus is a chronic or life-long condition in which blood sugar or glucose levels rise more than normal.
GLIMEPIRIDE+METFORMIN+PIOGLITAZONE may have an interaction with medicines used to treat bacterial infections (rifampicin, tetracycline, and clarithromycin), a medicine used to treat fungal infections (fluconazole), other oral antidiabetics, and medicines used to treat gout (probenecid).
check the label for directions before use. Gluconorm PG 2 Tablet PR is to be taken with food.
Store below 30°C
If you miss a dose of Gluconorm PG 2 Tablet PR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Take it with food to lower your chance of having an upset stomach.
It may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms such as cold sweats, cool pale skin, tremor, and anxiety.
Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).
Use it as advised by your doctor or check the label for directions before use. Gluconorm PG 2 Tablet PR is to be taken with food.
Q. Can I drink alcohol while taking Gluconorm PG 2 Tablet PR?
No, it is not safe to drink alcohol while using Gluconorm PG 2 Tablet PR. Drinking alcohol may lower your blood sugar levels (hypoglycemia). Also, it can increase the chances of lactic acidosis.
Q. What should I inform the doctor before taking Gluconorm PG 2 Tablet PR?
Before taking Gluconorm PG 2 Tablet PR inform your doctor if you have congestive heart failure, kidney problems, liver problems, swelling of the back of the eye. Inform the doctor if you are pregnant, breastfeeding or a premenopausal woman. Let the doctor know if you are taking any prescription and non-prescription medicines, vitamins, and herbal supplements.
Q. Can the use of Gluconorm PG 2 Tablet PR lead to Vitamin B12 deficiency?
Yes, the use of Gluconorm PG 2 Tablet PR can cause vitamin B12 deficiency as it contains metformin in it. On long-term use, it interferes with absorption of vitamin B12 in the stomach.
Q. Can the use of Gluconorm PG 2 Tablet PR cause hypoglycemia?
Yes, the use of Gluconorm PG 2 Tablet PR can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate and feeling anxious or shaky. It happens more often if you miss or delay your meal, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, regular monitoring of blood sugar level is important. Always carry some sugary item like a candy or chocolate with you.
Q. What are the instructions for the storage and disposal of Gluconorm PG 2 Tablet PR?
Keep this medicine in the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
