Manufacturer: Glenmark Pharmaceuticals Ltd
Salt Composition : Amitriptyline(10mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Goldep 10mg Tablet is normally taken before bedtime because it can make you feel sleepy. It can be taken with or without food. The dose and how often you need to take it will be decided by your doctor so that you get the right amount to control your symptoms. The initial dose should be increased with great caution under close supervision. This medicine may not work straight away and it could be several weeks before you get the full effects.
How long you need to use it will depend on what you are taking it for, but it is important to continue taking this medication even if you feel well. Do not stop taking the medicine suddenly without talking to your doctor. Stopping the medicine suddenly can worsen your conditions or cause other symptoms. Your dose may be modified or gradually decreased before stopping the medication.
The most common side effects of this medicine include nausea, constipation, sweating, dry mouth, sleepiness, tremor, dizziness, headache, speech disorder, accommodation disorder, palpitations, increased heart rate, orthostatic hypotension, and nasal congestion. It may also make you aggressive or confused and can lead to weight gain in some people.
This medicine is not addictive, but you can experience additional side effects (withdrawal symptoms) if you stop taking it suddenly. Most of the common side effects tend to be mild. Your doctor may be able to suggest ways of preventing or reducing side effects if they bother you or do not go away. Serious side effects associated with this medicine are rare.
Amitriptyline increases noradrenergic or serotonergic neurotransmission by blocking the norepinephrine or serotonin transporter (NET or SERT) at presynaptic terminals.
Pharmacokinetics. Amitriptyline is readily absorbed from the gastrointestinal tract (90–95%). Absorption is gradual with the peak concentration in blood plasma reached after about 4 hours.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Goldep
Constipation
Dryness in mouth
Orthostatic hypotension (sudden lowering of blood pressure on standing)
Weight gain
Aggressive behavior
Nasal congestion (stuffy nose)
Sleepiness
Dizziness
Headache
Decreased libido
Nausea
Fatigue
Confusion
Tremors
Speech disorder
Palpitations
Taste change
Paresthesia (tingling or pricking sensation)
Abnormality of voluntary movements
Loss of accommodation
Atrioventricular block
Micturition disorders
Erectile dysfunction
Abnormal ECG
Decreased sodium level in blood
Amitriptyline should not be used if there is a history of QTc prolongation, arrhythmias, recent myocardial infarction, or heart failure, as per the FDA product labeling. Amitriptyline toxicity may cause acute myocardial infarction.
Goldep 10mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is unsafe to consume alcohol with Goldep 10mg Tablet.
Goldep 10mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
The Non-FDA approved indications are anxiety, post-traumatic stress disorder, insomnia, chronic pain (diabetic neuropathy, fibromyalgia), irritable bowel syndrome, interstitial cystitis (bladder pain syndrome), migraine prophylaxis, postherpetic neuralgia, and sialorrhea.
When used along with amitriptyline, some drugs may cause an increase in serotonin concentrations; such drugs include isocarboxazid, phenelzine, procarbazine, safinamide, selegiline, tranylcypromine, sertraline. These drugs can cause serotonin syndrome.
Do not chew, crush or break it. Goldep 10mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
If you miss a dose of Goldep 10mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
It may take 4 to 6 weeks for Goldep 10mg Tablet to start working. Keep taking it as prescribed.
It may cause sleepiness. Take it at bedtime and do not drive or do anything requiring concentration until you know how it affects you.
Avoid consuming alcohol when taking Goldep 10mg Tablet as it may cause excessive sleepiness.
Monitor your weight during the treatment as this medicine can cause weight gain and increased appetite.
It may cause sudden drop in your blood pressure. Rise slowly if you have been sitting or lying down.
Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when an antidepressant medicine is started or when the dose is changed.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Goldep 10mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Q. What other lifestyle changes should I make to get maximum benefit of Goldep 10mg Tablet?
Antidepressants, including Goldep 10mg Tablet, are just one of several approaches to treat depression. Certain lifestyle changes can help you get maximum benefit of Goldep 10mg Tablet and help you recover fast. Keeping active and eating a healthy diet can make a significant difference to how quickly you recover from depression. Think positively and try to discuss your thoughts with others to reduce stress. Practice yoga or take up a hobby. Ensure that you have a sound sleep to calm your mind. Stay away from smoking or alcohol consumption as these will only worsen your depression. Take your medicines as prescribed even if you start feeling better.
Q. Is there anything I need to be careful about while on therapy with Goldep 10mg Tablet?
Goldep 10mg Tablet may cause drowsiness and dizziness, especially in the beginning of the treatment. So, avoid driving or using machinery until you know how the medicine affects you. Also, it is not advisable to drink alcohol during treatment with this medicine as it might increase sleepiness.
Q. Can the use of Goldep 10mg Tablet affect my sex life?
Yes, Goldep 10mg Tablet can affect sex life in both men and women. It may cause decreased sexual desire or you may experience discomfort during intercourse. Men may experience inability to develop or maintain an erection during sexual activity and may be unable to have an orgasm. If you notice these symptoms, do not stop taking the medicine but consult your doctor.
Q. I have been taking Goldep 10mg Tablet for depression since a week and recently I have been wanting to harm myself. What should I do? Is it because of the medicine?
You should immediately consult your doctor or go to the hospital. Your suicidal tendencies may have increased because of your disease or the medicine. Generally, Goldep 10mg Tablet takes about 2 weeks to show its effect but may take longer. Therefore, when you start taking Goldep 10mg Tablet, you may have thoughts about killing or harming yourself. This is more common in people who previously had suicidal tendencies or are young adults (less than 25 years old). However, the effect of medicine is different for every individual.
