Manufacturer: Sun Pharmaceutical Industries Ltd
Salt Composition : Ciclosporin(50mg)
Strip of 5 Tablet
(Inclusive of all taxes)
The amount of Graftin 50mg Tablet you take depends on your weight, medical condition, and what you are being treated for. Your doctor will plan the correct dose for you. Do not change the dose without talking to your doctor. It can be taken with or without food. It is better to take it, in the same way, and at the same time every day to get the maximum benefit. Keep taking it for as long as you have been told to, even if you feel well. Stopping treatment may increase the risk of your transplanted organ being rejected.
The most common side effects of this medicine include headache, unusual growth of facial or body hair, high blood pressure, diarrhea, and shaking or tremors. Because it lowers your immune system, you may also catch more infections than usual. Tell your doctor straight away if you develop an infection. For the same reason, you may be more at risk of developing some cancers, particularly of the skin. You should limit your exposure to sunlight.
Before taking this medicine you should tell your doctor if you have liver or kidney problems, high blood pressure, gout (increased uric acid levels in the blood), or epilepsy. Also, tell your doctor about all other medicines you are taking as they may affect the working of the medicine. This medicine should only be used in pregnancy if it is clearly needed. However, it is not recommended while breastfeeding. You will have frequent medical tests while taking this medicine to check your blood pressure, liver and kidney function, and mineral levels. The results of tests may lead to changes in your dose.
The mechanism of action of cyclosporine is as a calcineurin inhibitor, a cytochrome P450 3A4 inhibitor, and a P-glycoprotein inhibitor. Cyclosporin A (CsA) inhibits the synthesis of interleukins (IL), including IL-2, which is essential for the self-activation of T lymphocytes (LT) and their differentiation.
Cyclosporine (CsA) is a lipophilic, immunosuppressive peptide which selectively inhibits T-lymphocyte activation in response to antigen stimulation. Although it is the drug of choice in organ transplantation, its clinical use is hampered by toxicity and unpredictable pharmacokinetics.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Graftin
Headache
Nausea
Vomiting
Increased hair growth
High blood pressure
Renal dysfunction
Loss of appetite
Diarrhea
Tremors
Contraindications : Cyclosporine is contraindicated in patients with a hypersensitivity to cyclosporine, abnormal renal function, uncontrolled hypertension, uncontrolled infections and malignancy.
Graftin 50mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Consuming alcohol with Graftin 50mg Tablet does not cause any harmful side effects.
Graftin 50mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Cyclosporine is an immunosuppressive agent used to treat organ rejection post-transplant. It also has use in certain other autoimmune diseases, treatment of organ rejection in kidney, liver, and heart allogeneic transplants, rheumatoid arthritis when the condition has not adequately responded to methotrexate.
Antibiotics. Taking cyclosporine with certain antibiotics may lead to an increased risk of kidney damage. ...
Nonsteroidal anti-inflammatory drugs (NSAIDs) ...
Antifungals. ...
Acid reflux drugs. ...
Birth control drugs. ...
Immunity-suppressing drug. ...
High cholesterol drugs. ...
Blood pressure drugs.
Do not chew, crush or break it. Graftin 50mg Tablet is to be taken with food.
Store below 30°C
If you miss a dose of Graftin 50mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Graftin 50mg Tablet is used to prevent organ rejection in transplant patients.
It is also used to treat arthritis and immune disorders of the eyes, lungs, muscles, skin, nerves, and blood vessels.
It may take 3 to 4 months for the medication to work. Keep taking it as prescribed.
Your doctor may get regular blood tests done to check the levels of blood cells in your blood. Inform your doctor if you experience unexplained bruising or bleeding, sore throat, mouth ulcers, fever or general illness.
Your doctor may monitor your kidney function regularly. Drink 8 to 10 glasses of water per day to help with your kidney function.
Do not stop taking Graftin 50mg Tablet without talking to your doctor first.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Graftin 50mg Tablet is to be taken with food.
Q. Is Graftin 50mg Tablet a steroid?
No, Graftin 50mg Tablet is not a steroid. It belongs to a group of medicines known as immunosuppressive agents. It decreases the action of the body’s immune system.
Q. Can Graftin 50mg Tablet cause weight gain?
Graftin 50mg Tablet may either cause an increase or decrease in weight. However, the changes in weight are uncommon side effects of this medicine. Consult your doctor if these side effects worry you.
Q. Does Graftin 50mg Tablet cause hair growth?
Yes, the use of Graftin 50mg Tablet may cause abnormal hair growth (hypertrichosis) as a common side effect of Graftin 50mg Tablet, though it does not affect everyone.
Q. Does Graftin 50mg Tablet cause fatigue?
Yes, Graftin 50mg Tablet may cause fatigue as a common side effect. However, fatigue could also be due to an underlying disease. Discuss with your doctor if this side effect worries you.
