Manufacturer: Medley Pharmaceuticals
Salt Composition : Nitroglycerin(0.4mg)
Packet of 200Mdi Sublingual Spray
(Inclusive of all taxes)
GTN Spray should be taken at the first sign of chest pain. It should be used in the dose and duration as advised by your doctor. Seek medical help immediately if your chest pain continues for more than 15 minutes. Some people may be advised to use this medicine prior to any exertional activity or exercise, which may precipitate angina.
The most common side effect of this medicine is a headache which may be severe. This can sometimes be helped by drinking plenty of fluids and avoiding alcohol. You may also experience lightheadedness, which could increase your risk of having a fall.
Do not use this medicine if you are taking medicines to treat high blood pressure in your lungs (pulmonary hypertension), or erectile dysfunction; or if you have anemia or glaucoma (increased pressure inside the eye). Always tell your doctor what other health conditions you have and what other medicines you are taking. It is best not to drink alcohol with this medicine as it increases some of the side effects. If you are affected by dizziness, avoid driving. If you are pregnant, thinking about becoming pregnant, or breastfeeding, ask your doctor before taking this medicine.
As with other nitrates used to treat anginal chest pain, nitroglycerin converts to nitric oxide (NO) in the body. NO then activates the enzyme guanylyl cyclase, which converts guanosine triphosphate (GTP) to guanosine 3',5'-monophosphate (cGMP) in vascular smooth muscle and other tissues.
Pharmacokinetics and Drug Metabolism Absorption: Nitroglycerin is rapidly absorbed following sublingual administration of Nitrostat tablets. Mean peak nitroglycerin plasma concentrations occur at a mean time of approximately 6 to 7 minutes postdose (Table 1).
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of GTN
Drowsiness
Vertigo
Blurred vision
Decreased blood pressure
Dizziness
Headache
Increased heart rate
Lightheadedness
Paresthesia (tingling or pricking sensation)
Nitroglycerin is contraindicated in patients that have reported allergic symptoms to the medication. Known history of increased intracranial pressure, severe anemia, right-sided myocardial infarction, or hypersensitivity to nitroglycerin are contraindications to nitroglycerin therapy.
GTN Spray is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Consuming alcohol while taking GTN Spray may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
GTN Spray is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Nitroglycerin sublingual tablets are used to treat episodes of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart). It is also used just before activities that may cause episodes of angina in order to prevent the angina from occurring.
Nitroglycerin may interact with certain other medications, such as PDE-5 inhibitors. PDE-5 inhibitors are drugs that doctors give to treat erectile dysfunction. Viagra, Cialis, and Levitra are PDE-5 inhibitors. As with nitroglycerin, these drugs also cause increased blood flow and can lower blood pressure.
lift your tongue and press the bottle button down firmly to spray the medicine under your tongue. Close your mouth after you have sprayed the dose. You should not shake the bottle before use. GTN Spray
Store below 30°C
GTN Spray may cause dizziness or sleepiness. Do not drive or do anything that requires concentration until you know how it affects you.
Do not consume alcohol while taking GTN Spray as it may cause increased dizziness.
It may cause headaches which usually go away after a few days of continued treatment. Inform your doctor if it persists.
You may develop tolerance to GTN Spray with time, meaning that the same dose may be less effective next time. Follow the prescribed dosing schedule to avoid this.
Stop taking medications (prescribed for erectile dysfunction) like sildenafil or tadalafil while on treatment with GTN Spray as it may cause low blood pressure.
To use the spray, open your mouth, lift your tongue and press the bottle button down firmly to spray the medicine under your tongue. Close your mouth after you have sprayed the dose. You should not shake the bottle before use. GTN Spray may be taken with or without food, but it is better to take it at a fixed time.
Q. How long does it take for GTN Spray to act?
GTN Spray starts working very quickly. If the medicine is kept under the tongue, the effect starts 1-3 minutes later and reaches its maximum within 5 minutes.
Q. What effect does GTN Spray have on blood pressure?
GTN Spray decreases the blood pressure by relaxing the blood vessels, but is not recommended for the treatment of high blood pressure. The drop in blood pressure may cause lightheadedness, especially when changing your position suddenly.
Q. Does the effect of GTN Spray wear off after sometime?
Yes, excessive use of GTN Spray may cause tolerance which means that GTN Spray may lose its effectiveness on you. Therefore, usually the doctors prescribe the smallest dose required for effective relief of acute angina attack. This helps maintain the effectiveness of GTN Spray.
Q. What does too much GTN Spray do?
Excess GTN Spray may result in low blood pressure, sweating, nausea, vomiting, headache, weak and fast pulse. It may also cause weakness, lightheadedness on standing and the patient might even faint. The patient will require emergency medical treatment in such a case.
